Stable Silicon Anode for Lithium-Ion Batteries through Covalent Bond Formation with a Binder via Esterification

2019 ◽  
Vol 11 (30) ◽  
pp. 26753-26763 ◽  
Author(s):  
Chul-Ho Jung ◽  
Kyeong-Ho Kim ◽  
Seong-Hyeon Hong
Keyword(s):  
Lithium Ion Batteries ◽  
Bond Formation ◽  
Covalent Bond ◽  
Lithium Ion ◽  
Silicon Anode ◽  
Covalent Bond Formation

Synthesis of [1]Rotaxane via Covalent Bond Formation and Its Unique Fluorescent Response by Energy Transfer in the Presence of Lithium Ion

2004 ◽  
Vol 126 (42) ◽  
pp. 13568-13569 ◽  
Author(s):  
Kazuhisa Hiratani ◽  
Maiko Kaneyama ◽  
Yoshinobu Nagawa ◽  
Emiko Koyama ◽  
Masatoshi Kanesato
Keyword(s):  
Energy Transfer ◽  
Bond Formation ◽  
Covalent Bond ◽  
Lithium Ion ◽  
Fluorescent Response ◽  
Covalent Bond Formation

CNTs-intertwined and N-doped porous carbon wrapped silicon anode for high performance lithium-ion batteries

2021 ◽  
pp. 160240
Author(s):  
Yiwei Qiu ◽  
Chenying Zhang ◽  
Chengkun Zhang ◽  
Qingshui Xie ◽  
Zhensong Qiao ◽  
...  
Keyword(s):  
Lithium Ion Batteries ◽  
Porous Carbon ◽  
High Performance ◽  
Lithium Ion ◽  
Silicon Anode

scholarly journals Chemical Investigations Into the Biosynthesis of the Gymnastatin and Dankastatin Alkaloids

2021 ◽  
Author(s):  
Bingqi Tong ◽  
Bridget Belcher ◽  
Daniel Nomura ◽  
Thomas Maimone
Keyword(s):  
Natural Products ◽  
Protein Function ◽  
Bond Formation ◽  
Covalent Bond ◽  
Fungal Strain ◽  
Fertile Ground ◽  
Covalent Bond Formation

Electrophilic natural products have provided fertile ground for understanding how nature inhibits protein function using covalent bond formation. The fungal strain Gymnascella dankaliensis has provided an especially interesting collection of...

Material Adhesion through Direct Covalent Bond Formation Assisted by Noncovalent Interactions

2021 ◽  
Author(s):  
Motofumi Osaki ◽  
Tomoko Sekine ◽  
Hiroyasu Yamaguchi ◽  
Yoshinori Takashima ◽  
Akira Harada
Keyword(s):  
Noncovalent Interactions ◽  
Bond Formation ◽  
Covalent Bond ◽  
Covalent Bond Formation

scholarly journals Mechanism of Covalent Binding of Ibrutinib to Bruton’s Tyrosine Kinase revealed by QM/MM Calculations

2020 ◽  
Author(s):  
Angus Voice ◽  
Gary Tresadern ◽  
Rebecca Twidale ◽  
Herman Van Vlijmen ◽  
Adrian Mulholland
Keyword(s):  
Tyrosine Kinase ◽  
Covalent Binding ◽  
Bond Formation ◽  
Covalent Bond ◽  
Covalent Modification ◽  
Mechanistic Study ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Covalent Inhibitors ◽  
Covalent Bond Formation

<p>Ibrutinib is the first covalent inhibitor of Bruton’s tyrosine kinase (BTK) to be used in the treatment of B-cell cancers. Understanding the mechanism of covalent inhibition is crucial for the design of safer and more selective covalent inhibitors that target BTK. There are questions surrounding the precise mechanism of covalent bond formation in BTK as there is no appropriate active site residue that can act as a base to deprotonate the cysteine thiol prior to covalent bond formation. To address this, we have investigated several mechanistic pathways of covalent modification of C481 in BTK by ibrutinib using QM/MM reaction simulations. The lowest energy pathway we identified involves a direct proton transfer from C481 to the acrylamide warhead in ibrutinib, followed by covalent bond formation to form an enol intermediate. There is a subsequent rate-limiting keto-enol tautomerisation step (DG<sup>‡</sup>=10.5 kcal mol<sup>-1</sup>) to reach the inactivated BTK/ibrutinib complex. Our results represent the first mechanistic study of BTK inactivation by ibrutinib to consider multiple mechanistic pathways. These findings should aid in the design of covalent drugs that target BTK and related proteins. </p>

Supramolecular Assembly-Enabled Homochiral Polymerization of Short (dA)n Oligonucleotides

2021 ◽  
Author(s):  
Sreejith Mangalath ◽  
Suneesh C Karunakaran ◽  
Gary Newnam ◽  
Gary Schuster ◽  
Nicholas Hud
Keyword(s):  
Supramolecular Chemistry ◽  
Bond Formation ◽  
Supramolecular Assembly ◽  
Covalent Bond ◽  
Complex Mixtures ◽  
Covalent Bond Formation

A goal of supramolecular chemistry is to create covalent polymers of precise composition and stereochemistry from complex mixtures by the reversible assembly of specific monomers prior to covalent bond formation....

In situ catalytic growth 3D multi-layers graphene sheets coated nano-silicon anode for high performance lithium-ion batteries

2019 ◽  
Vol 356 ◽  
pp. 895-903 ◽  
Author(s):  
Ming-Shan Wang ◽  
Guo-Liang Wang ◽  
Shuai Wang ◽  
Jun Zhang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Lithium Ion Batteries ◽  
High Performance ◽  
Lithium Ion ◽  
Silicon Anode ◽  
Graphene Sheets ◽  
Catalytic Growth ◽  
Nano Silicon
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