Back Cover: In Vivo Gold Complex Catalysis within Live Mice (Angew. Chem. Int. Ed. 13/2017)

2017 ◽  
Vol 56 (13) ◽  
pp. 3724-3724 ◽  
Author(s):  
Kazuki Tsubokura ◽  
Kenward K. H. Vong ◽  
Ambara R. Pradipta ◽  
Akihiro Ogura ◽  
Sayaka Urano ◽  
...  
Keyword(s):  
Gold Complex ◽  
Back Cover

Back Cover: In Vivo Synthesis of Polyhydroxylated Compounds from a “Hidden Reservoir” of Toxic Aldehyde Species (ChemCatChem 15/2017)

ChemCatChem ◽  
2017 ◽  
Vol 9 (15) ◽  
pp. 3085-3085
Author(s):  
Thomas Bayer ◽  
Sofia Milker ◽  
Thomas Wiesinger ◽  
Margit Winkler ◽  
Marko D. Mihovilovic ◽  
...  
Keyword(s):  
Back Cover ◽  
In Vivo Synthesis

scholarly journals Preparation and characterization of a colloidal gold-insulin complex with binding and biological activities identical to native insulin.

1988 ◽  
Vol 36 (4) ◽  
pp. 359-365 ◽  
Author(s):  
R M Smith ◽  
R I Goldberg ◽  
L Jarett
Keyword(s):  
Gold Particle ◽  
Biological Activities ◽  
Insulin Receptors ◽  
Gold Complex ◽  
Multivalent Ligands ◽  
Receptor Dynamics ◽  
Native Insulin

We studied the binding and biological activities of gold-insulin complexes to develop a complex with properties identical to native insulin. Stabilizing amounts of insulin absorbed to 5-, 10-, or 15-nm gold particles resulted in complexes with 40-327 insulin molecules per gold particle and 4-111 times the biological activity of unlabeled insulin, based on the molar concentration of gold complex. These data suggested that these complexes behaved as multivalent ligands. Gold-insulin complexes were prepared with 5% of the stabilizing insulin concentration and were stabilized with bovine serum albumin. This resulted in a complex with 5-7 insulin molecules per 10-nm gold particle, which stimulated glucose oxidation in rat adipocytes and competed with [125I]-insulin for binding to the insulin receptor identically to unlabeled insulin on an equimolar basis. The organization and distribution of insulin receptors occupied by this monovalent-behaving gold-insulin complex were virtually identical to previous observations using monomeric ferritin-insulin. Since multivalent ligands may affect receptor binding, re-distribution, and intracellular processing, the use of electron-dense probes that resemble the unlabeled ligand in biological and binding properties is appropriate when studying receptor dynamics of in vivo or in vitro biological systems. The gold-insulin complex developed in this study should serve this function.

In Vivo Gold Complex Catalysis within Live Mice

2017 ◽  
Vol 56 (13) ◽  
pp. 3579-3584 ◽  
Author(s):  
Kazuki Tsubokura ◽  
Kenward K. H. Vong ◽  
Ambara R. Pradipta ◽  
Akihiro Ogura ◽  
Sayaka Urano ◽  
...  
Keyword(s):  
Gold Complex

In Vivo Gold Complex Catalysis within Live Mice

2017 ◽  
Vol 129 (13) ◽  
pp. 3633-3638 ◽  
Author(s):  
Kazuki Tsubokura ◽  
Kenward K. H. Vong ◽  
Ambara R. Pradipta ◽  
Akihiro Ogura ◽  
Sayaka Urano ◽  
...  
Keyword(s):  
Gold Complex

scholarly journals Rücktitelbild: In Vivo Gold Complex Catalysis within Live Mice (Angew. Chem. 13/2017)

2017 ◽  
Vol 129 (13) ◽  
pp. 3778-3778
Author(s):  
Kazuki Tsubokura ◽  
Kenward K. H. Vong ◽  
Ambara R. Pradipta ◽  
Akihiro Ogura ◽  
Sayaka Urano ◽  
...  
Keyword(s):  
Gold Complex

scholarly journals Back Cover: Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (Angew. Chem. Int. Ed. 27/2013)

2013 ◽  
Vol 52 (27) ◽  
pp. 7044-7044
Author(s):  
Tae Hyung Kim ◽  
Magdalena Swierczewska ◽  
Yumin Oh ◽  
AeRyon Kim ◽  
Dong Gyu Jo ◽  
...  
Keyword(s):  
Therapeutic Proteins ◽  
Back Cover ◽  
Fast Screening

scholarly journals Inside Back Cover: Non-Aqueous Sol-Gel Synthesis of Ultra Small Persistent Luminescence Nanoparticles for Near-Infrared In Vivo Imaging (Chem. Eur. J. 20/2015)

2015 ◽  
Vol 21 (20) ◽  
pp. 7623-7623
Author(s):  
Eliott Teston ◽  
Sophie Richard ◽  
Thomas Maldiney ◽  
Nicole Lièvre ◽  
Guillaume Yangshu Wang ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Sol Gel ◽  
Persistent Luminescence ◽  
Back Cover ◽  
Sol Gel Synthesis
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