A Case Study of the Likes and Dislikes of DNA and RNA in Self-Assembly

2015 ◽  
Vol 54 (50) ◽  
pp. 15118-15121 ◽  
Author(s):  
Hua Zuo ◽  
Siyu Wu ◽  
Mo Li ◽  
Yulin Li ◽  
Wen Jiang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Dna And Rna

A Case Study of the Likes and Dislikes of DNA and RNA in Self-Assembly

2015 ◽  
Vol 127 (50) ◽  
pp. 15333-15336 ◽  
Author(s):  
Hua Zuo ◽  
Siyu Wu ◽  
Mo Li ◽  
Yulin Li ◽  
Wen Jiang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Dna And Rna

Inside Cover: A Case Study of the Likes and Dislikes of DNA and RNA in Self-Assembly (Angew. Chem. Int. Ed. 50/2015)

2015 ◽  
Vol 54 (50) ◽  
pp. 14982-14982
Author(s):  
Hua Zuo ◽  
Siyu Wu ◽  
Mo Li ◽  
Yulin Li ◽  
Wen Jiang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Dna And Rna

Innentitelbild: A Case Study of the Likes and Dislikes of DNA and RNA in Self-Assembly (Angew. Chem. 50/2015)

2015 ◽  
Vol 127 (50) ◽  
pp. 15194-15194
Author(s):  
Hua Zuo ◽  
Siyu Wu ◽  
Mo Li ◽  
Yulin Li ◽  
Wen Jiang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Dna And Rna

scholarly journals Tuning the Morphology of Nanostructured Peptide Films by the Introduction of a Secondary Structure Conformational Constraint: A Case Study of Hierarchical Self-Assembly

2018 ◽  
Vol 122 (24) ◽  
pp. 6305-6313 ◽  
Author(s):  
Marta De Zotti ◽  
Beatrice Muzzi ◽  
Emanuela Gatto ◽  
Benedetta Di Napoli ◽  
Claudia Mazzuca ◽  
...  
Keyword(s):  
Secondary Structure ◽  
Self Assembly ◽  
Conformational Constraint

scholarly journals Self‐Assembly of DNA and RNA Building Blocks Explored by Nitrogen‐14 NMR Crystallography: Structure and Dynamics

ChemPhysChem ◽  
2020 ◽  
Vol 21 (10) ◽  
pp. 1044-1051 ◽  
Author(s):  
Diego Carnevale ◽  
Marcel Hollenstein ◽  
Geoffrey Bodenhausen
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Structure And Dynamics ◽  
Dna And Rna ◽  
Nmr Crystallography

scholarly journals Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization

2018 ◽  
Author(s):  
Ahmed M. Malik ◽  
Roberto A. Miguez ◽  
Xingli Li ◽  
Ye-Shih Ho ◽  
Eva L. Feldman ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Self Assembly ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Nucleic Acid Binding ◽  
Rna Recognition Motifs ◽  
Matrin 3 ◽  
Dna And Rna ◽  
Acid Processing ◽  
Recognition Motifs

ABSTRACTAbnormalities in nucleic acid processing are associated with the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin 3 (MATR3), a poorly understood DNA- and RNA-binding protein, cause familial ALS/FTD, and MATR3 pathology is a feature of sporadic disease, suggesting that MATR3 dysfunction is integrally linked to ALS pathogenesis. Using a primary neuron model to assess MATR3-mediated toxicity, we noted that neurons were bidirectionally vulnerable to MATR3 levels, with pathogenic MATR3 mutants displaying enhanced toxicity. MATR3’s zinc finger domains partially modulated toxicity, but elimination of its RNA recognition motifs had no effect on neuronal survival, instead facilitating its self-assembly into liquid-like droplets. In contrast to other RNA-binding proteins associated with ALS, cytoplasmic MATR3 redistribution mitigated neurodegeneration, suggesting that nuclear MATR3 mediates toxicity. Our findings offer a foundation for understanding MATR3-related neurodegeneration and how nucleic acid binding functions, localization, and pathogenic mutations drive sporadic and familial disease.

Comparing Ion Distributions around RNA and DNA Helical and Loop-loop Motifs

2008 ◽  
Vol 1130 ◽  
Author(s):  
Andrey V Semichaevsky ◽  
Ashley E Marlowe ◽  
Yaroslava G Yingling
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Assembly Process ◽  
Dna Motifs ◽  
Dna And Rna ◽  
Ion Distributions ◽  
Concentration Of Ions ◽  
The Stability ◽  
Dynamics Simulations ◽  
Rna And Dna

AbstractNucleic acid nanoparticles can self-assembly through the formation of complementary loop-loop interactions or stem-stem interactions. Presence and concentration of ions can significantly affect the self-assembly process and the stability of the nanostructure. In this paper we use explicit molecular dynamics simulations to examine the variations in cationic distributions around DNA and RNA helices and loop-loop interactions with identical sequence except for Thymine to Uracil substitution. Our simulations show that the ionic distributions are different around RNA and DNA motifs which could be related to the discrepancy in stability of loop-loop complexes.

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