Post-Assembly Stabilization of Rationally Designed DNA Crystals

2015 ◽  
Vol 54 (34) ◽  
pp. 9936-9939 ◽  
Author(s):  
Jiemin Zhao ◽  
Arun Richard Chandrasekaran ◽  
Qian Li ◽  
Xiang Li ◽  
Ruojie Sha ◽  
...  
Keyword(s):  
2019 ◽  
Vol 21 (1) ◽  
pp. 469-493 ◽  
Author(s):  
Dominic Scalise ◽  
Rebecca Schulman

In recent years, a diverse set of mechanisms have been developed that allow DNA strands with specific sequences to sense information in their environment and to control material assembly, disassembly, and reconfiguration. These sequences could serve as the inputs and outputs for DNA computing circuits, enabling DNA circuits to act as chemical information processors to program complex behavior in chemical and material systems. This review describes processes that can be sensed and controlled within such a paradigm. Specifically, there are interfaces that can release strands of DNA in response to chemical signals, wavelengths of light, pH, or electrical signals, as well as DNA strands that can direct the self-assembly and dynamic reconfiguration of DNA nanostructures, regulate particle assemblies, control encapsulation, and manipulate materials including DNA crystals, hydrogels, and vesicles. These interfaces have the potential to enable chemical circuits to exert algorithmic control over responsive materials, which may ultimately lead to the development of materials that grow, heal, and interact dynamically with their environments.


2016 ◽  
Vol 72 (3) ◽  
pp. 430-439 ◽  
Author(s):  
Armin Wagner ◽  
Ramona Duman ◽  
Keith Henderson ◽  
Vitaliy Mykhaylyk

Structure solution based on the weak anomalous signal from native (protein and DNA) crystals is increasingly being attempted as part of synchrotron experiments. Maximizing the measurable anomalous signal by collecting diffraction data at longer wavelengths presents a series of technical challenges caused by the increased absorption of X-rays and larger diffraction angles. A new beamline at Diamond Light Source has been built specifically for collecting data at wavelengths beyond the capability of other synchrotron macromolecular crystallography beamlines. Here, the theoretical considerations in support of the long-wavelength beamline are outlined and the in-vacuum design of the endstation is discussed, as well as other hardware features aimed at enhancing the accuracy of the diffraction data. The first commissioning results, representing the first in-vacuum protein structure solution, demonstrate the promising potential of the beamline.


2016 ◽  
Vol 49 (10) ◽  
pp. 105501 ◽  
Author(s):  
Sreekantha Reddy Dugasani ◽  
Taehyun Hwang ◽  
Jang Ah Kim ◽  
Bramaramba Gnapareddy ◽  
Taesung Kim ◽  
...  

Science News ◽  
1999 ◽  
Vol 156 (1) ◽  
pp. 7
Author(s):  
John Travis
Keyword(s):  

2018 ◽  
Vol 130 (50) ◽  
pp. 16767-16770 ◽  
Author(s):  
Jiemin Zhao ◽  
Yue Zhao ◽  
Zhe Li ◽  
Yong Wang ◽  
Ruojie Sha ◽  
...  
Keyword(s):  

2013 ◽  
Vol 58 (15) ◽  
pp. 1450-1455
Author(s):  
ChangLong LIU ◽  
ZhiYong SHEN ◽  
Ming ZHOU ◽  
LiZhou ZHUANG ◽  
George AMOAKO ◽  
...  

Author(s):  
Nadrian Seeman ◽  
Jens Birktoft ◽  
Ruojie Sha ◽  
Hongzhou Gu ◽  
Tong Wang ◽  
...  
Keyword(s):  

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