Total Synthesis of Resveratrol-Based Natural Products Using a Palladium-Catalyzed Decarboxylative Arylation and an Oxidative Heck Reaction

2014 ◽  
Vol 53 (9) ◽  
pp. 2473-2476 ◽  
Author(s):  
Felix Klotter ◽  
Armido Studer
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Heck Reaction ◽  
Palladium Catalyzed

First total synthesis of antihypertensive natural products S-(+)-XJP and R-(−)-XJP

2014 ◽  
Vol 12 (37) ◽  
pp. 7338-7344 ◽  
Author(s):  
Chaolei Wang ◽  
Guoxiang Wei ◽  
Xue Yang ◽  
Hequan Yao ◽  
Jieyun Jiang ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Heck Reaction ◽  
Intramolecular Heck Reaction

The first total synthesis of S-(+)-XJP and R-(−)-XJP has been achieved via intramolecular Heck reaction. A latent functionality strategy was implemented to circumvent the racemization in this endeavor.

Palladium-Catalyzed Formation of Substituted Tetrahydropyrans: Mechanistic Insights and Structural Revision of Natural Products

Synthesis ◽  
2019 ◽  
Vol 51 (07) ◽  
pp. 1545-1560 ◽  
Author(s):  
Ronaldo Pilli ◽  
Franco Della-Felice ◽  
Francisco de Assis ◽  
Ariel Sarotti
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Palladium Catalyst ◽  
Structural Revision ◽  
Palladium Catalyzed ◽  
Acyclic Precursor ◽  
Comprehensive Study

A comprehensive study on the stereochemical outcome of palladium-catalyzed formation of 2,4,6-trisubstituted tetrahydropyrans through cyclization of the corresponding allylic acetates using both Pd(0) and Pd(II) catalysts is presented. We have found that the stereochemical outcome of this cyclization is dependent not only on the ­stereochemistry of the acyclic precursor but also on the nature of the palladium catalyst. These results were applied to the total synthesis of the putative structure of cryptoconcatone H. Experimental and computational DP4+ NMR results were used to assess the structures proposed for cryptoconcatones K and L.

Intramolecular Heck Reaction in Total Synthesis of Natural Products: An Update

2021 ◽  
Vol 2021 (14) ◽  
pp. 2057-2076
Author(s):  
Debobrata Paul ◽  
Subhendu Das ◽  
Sanu Saha ◽  
Himangshu Sharma ◽  
Rajib Kumar Goswami
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Heck Reaction ◽  
Intramolecular Heck Reaction

Enantioselective Palladium-Catalyzed Total Synthesis of Vitamin E by Employing a Domino Wacker–Heck Reaction

2006 ◽  
Vol 12 (34) ◽  
pp. 8770-8776 ◽  
Author(s):  
Lutz F. Tietze ◽  
Florian Stecker ◽  
Julia Zinngrebe ◽  
Konrad M. Sommer
Keyword(s):  
Vitamin E ◽  
Total Synthesis ◽  
Heck Reaction ◽  
Palladium Catalyzed

ChemInform Abstract: Palladium-Catalyzed Macrocyclizations in the Total Synthesis of Natural Products

ChemInform ◽  
2015 ◽  
Vol 46 (15) ◽  
pp. no-no
Author(s):  
Thomas O. Ronson ◽  
Richard J. K. Taylor ◽  
Ian J. S. Fairlamb
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Palladium Catalyzed

Application of Dess-Martin oxidation in total synthesis of natural products

2020 ◽  
Vol 17 ◽  
Author(s):  
Majid M. Heravi ◽  
Tayebe Momeni ◽  
Vahideh Zadsirjan ◽  
Leila Mohammadi
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Selective Oxidation ◽  
Secondary Alcohols ◽  
Aldehydes And Ketones

: Dess–Martin periodinane (DMP), is a commercially available chemical, frequently being utilized as a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. DMP shows several merits over other common oxidative agent such as chromium- and DMSO-based oxidants, thus it is habitually employed in the total synthesis of natural products. In this review, we try to underscore the applications of DMP as an effective oxidant in an appropriate step (steps) in the multistep total synthesis of natural products.

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