First total synthesis of antihypertensive natural products S-(+)-XJP and R-(−)-XJP

2014 ◽  
Vol 12 (37) ◽  
pp. 7338-7344 ◽  
Author(s):  
Chaolei Wang ◽  
Guoxiang Wei ◽  
Xue Yang ◽  
Hequan Yao ◽  
Jieyun Jiang ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Heck Reaction ◽  
Intramolecular Heck Reaction

The first total synthesis of S-(+)-XJP and R-(−)-XJP has been achieved via intramolecular Heck reaction. A latent functionality strategy was implemented to circumvent the racemization in this endeavor.

Intramolecular Heck Reaction in Total Synthesis of Natural Products: An Update

2021 ◽  
Vol 2021 (14) ◽  
pp. 2057-2076
Author(s):  
Debobrata Paul ◽  
Subhendu Das ◽  
Sanu Saha ◽  
Himangshu Sharma ◽  
Rajib Kumar Goswami
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Heck Reaction ◽  
Intramolecular Heck Reaction

Bioinspired Total Synthesis of Marine Anti-Cancer Meroterpenoids Dysideanone B and Dysiherbol A and Structure Revision of Dysiherbol A

Synlett ◽  
2021 ◽  
Author(s):  
Zhaoyong Lu ◽  
Chuanke Chong
Keyword(s):  
Total Synthesis ◽  
Heck Reaction ◽  
Recent Progress ◽  
Benzyl Bromide ◽  
Radical Cyclization ◽  
Ethoxy Group ◽  
Anti Cancer ◽  
Structure Revision ◽  
A Site ◽  
Intramolecular Heck Reaction

Our recent progress on the total synthesis of marine anti-cancer sesquiterpene quinone/hydroquinone dysideanone B and dysiherbol A was briefly highlighted. This success relied on some key transformations. The union of the terpene and quinone/hydroquinone moieties was realized through a site and stereoselective α-position alkylation of Wieland–Miescher ketone derivative with a bulky benzyl bromide. The 6/6/6/6-tetracycle of dysideanone B was constructed using an intramolecular radical cyclization and the 6/6/5/6-fused core structure of dysiherbol A was forged by an intramolecular Heck reaction, respectively. The possible origin of ethoxy group in dysideanone B was revealed by mimicking the isolation conditions at a late-stage. The structure of dysiherbol A was revised through the total synthesis of this natural product. Schmalz’s synthesis of dysiherbol A was also included.

scholarly journals Efficient Route to 4a-Methyltetrahydrofluorenes: A Total Synthesis of (.+-.)-Dichroanal B via Intramolecular Heck Reaction.

ChemInform ◽  
2006 ◽  
Vol 37 (34) ◽  
Author(s):  
Loic Planas ◽  
Muneto Mogi ◽  
Hirofumi Takita ◽  
Tetsuya Kajimoto ◽  
Manabu Node
Keyword(s):  
Total Synthesis ◽  
Heck Reaction ◽  
Efficient Route ◽  
Intramolecular Heck Reaction

First asymmetric total synthesis of (+)-taiwaniaquinol D and (−)-taiwaniaquinone D by using intramolecular Heck reaction

Tetrahedron ◽  
2013 ◽  
Vol 69 (19) ◽  
pp. 3841-3846 ◽  
Author(s):  
Minoru Ozeki ◽  
Megumi Satake ◽  
Toshinori Toizume ◽  
Shintaro Fukutome ◽  
Kenji Arimitsu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Heck Reaction ◽  
Asymmetric Total Synthesis ◽  
Intramolecular Heck Reaction

Asymmetric Total Synthesis of (-)-Galanthamine via Intramolecular Heck Reaction of Conjugated Diene

Synlett ◽  
2013 ◽  
Vol 24 (03) ◽  
pp. 379-382 ◽  
Author(s):  
Jinsung Tae ◽  
Juhee Choi ◽  
Hyunseok Kim ◽  
Sangyun Park
Keyword(s):  
Total Synthesis ◽  
Heck Reaction ◽  
Conjugated Diene ◽  
Asymmetric Total Synthesis ◽  
Intramolecular Heck Reaction
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