Water-Enabled Self-Healing of Polyelectrolyte Multilayer Coatings

2011 ◽  
Vol 50 (48) ◽  
pp. 11378-11381 ◽  
Author(s):  
Xu Wang ◽  
Feng Liu ◽  
Xiwei Zheng ◽  
Junqi Sun
Keyword(s):  
Multilayer Coatings ◽  
Self Healing ◽  
Polyelectrolyte Multilayer

Humidity-Triggered Self-Healing of Microporous Polyelectrolyte Multilayer Coatings for Hydrophobic Drug Delivery

2015 ◽  
Vol 25 (48) ◽  
pp. 7470-7477 ◽  
Author(s):  
Xia-Chao Chen ◽  
Ke-Feng Ren ◽  
Jia-Hui Zhang ◽  
Dan-Dan Li ◽  
Emily Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multilayer Coatings ◽  
Self Healing ◽  
Hydrophobic Drug ◽  
Polyelectrolyte Multilayer

Water-Enabled Self-Healing of Polyelectrolyte Multilayer Coatings

2011 ◽  
Vol 123 (48) ◽  
pp. 11580-11583 ◽  
Author(s):  
Xu Wang ◽  
Feng Liu ◽  
Xiwei Zheng ◽  
Junqi Sun
Keyword(s):  
Multilayer Coatings ◽  
Self Healing ◽  
Polyelectrolyte Multilayer

Robust Anti-Infective Multilayer Coatings with Rapid Self-Healing Property

2021 ◽  
pp. 111828
Author(s):  
Chao Zhou ◽  
Juntao Zhou ◽  
Xiaoqing Ma ◽  
Dicky Pranantyo ◽  
Jingjing Li ◽  
...  
Keyword(s):  
Multilayer Coatings ◽  
Self Healing ◽  
Healing Property

Biomimetic multilayer coatings deliver gentamicin and reduce implant-related osteomyelitis in rats

2019 ◽  
Vol 64 (4) ◽  
pp. 383-395
Author(s):  
Steffi Grohmann ◽  
Manuela Menne ◽  
Diana Hesse ◽  
Sabine Bischoff ◽  
René Schiffner ◽  
...  
Keyword(s):  
Orthopedic Surgery ◽  
Material Properties ◽  
Bulk Material ◽  
Local Delivery ◽  
Multilayer Coatings ◽  
Assembly Process ◽  
Polyelectrolyte Multilayer ◽  
Cytotoxic Effects ◽  
Joint Infections ◽  
Main Components

Abstract Implant-related infections like periprosthetic joint infections (PJI) are still a challenging issue in orthopedic surgery. In this study, we present a prophylactic anti-infective approach based on a local delivery of the antibiotic gentamicin. The local delivery is achieved via a nanoscale polyelectrolyte multilayer (PEM) coating that leaves the bulk material properties of the implant unaffected while tuning the surface properties. The main components of the coating, i.e. polypeptides and sulfated glycosaminoglycans (sGAG) render this coating both biomimetic (matrix mimetic) and biodegradable. We show how adaptions in the conditions of the multilayer assembly process and the antibiotic loading process affect the amount of delivered gentamicin. The highest concentration of gentamicin could be loaded into films composed of polypeptide poly-glutamic acid when the pH of the loading solution was acidic. The concentration of gentamicin on the surface could be tailored with the number of deposited PEM layers. The resulting coatings reveal a bacteriotoxic effect on Staphylococcus cells but show no signs of cytotoxic effects on MC3T3-E1 osteoblasts. Moreover, when multilayer-coated titanium rods were implanted into contaminated medullae of rat tibiae, a reduction in the development of implant-related osteomyelitis was observed. This reduction was more pronounced for the multifunctional, matrix-mimetic heparin-based coatings that only deliver lower amounts of gentamicin.

Anti-Oxidative and Antibacterial Self-Healing Edible Polyelectrolyte Multilayer Film in Fresh-Cut Fruits

2018 ◽  
Vol 18 (4) ◽  
pp. 2592-2600 ◽  
Author(s):  
Xuefan Liu ◽  
Wei Han ◽  
Yanxi Zhu ◽  
Hongyun Xuan ◽  
Jiaoyu Ren ◽  
...  
Keyword(s):  
Multilayer Film ◽  
Self Healing ◽  
Polyelectrolyte Multilayer ◽  
Fresh Cut ◽  
Polyelectrolyte Multilayer Film

Saline-enabled self-healing of polyelectrolyte multilayer films

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 8877-8881 ◽  
Author(s):  
Xiaoxia Hu ◽  
Shimei Xu ◽  
Shun Feng ◽  
Jide Wang ◽  
Jie Xu
Keyword(s):  
Normal Saline ◽  
Multilayer Film ◽  
Multilayer Films ◽  
Self Healing ◽  
Polyelectrolyte Multilayer ◽  
Rapid Healing ◽  
Polyelectrolyte Multilayer Film

After introducing a third polyelectrolyte, the healing ability of polyelectrolyte multilayer film fabricated by LbL technique is largely enhanced, and can undergo rapid healing of several tens of micrometer-sized cuts when exposed to normal saline.

scholarly journals Fast Self-Healing of Polyelectrolyte Multilayer Nanocoating and Restoration of Super Oxygen Barrier

2017 ◽  
Vol 38 (10) ◽  
pp. 1700064 ◽  
Author(s):  
Yixuan Song ◽  
Kevin P. Meyers ◽  
Joseph Gerringer ◽  
Ramesh K. Ramakrishnan ◽  
Mohammad Humood ◽  
...  
Keyword(s):  
Oxygen Barrier ◽  
Self Healing ◽  
Polyelectrolyte Multilayer
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