Determination of the Enantiomeric Ratio of Unprotected Amino Acids by NMR Spectroscopy withC2-Chiral Palladium Compounds

1996 ◽  
Vol 35 (12) ◽  
pp. 1344-1346 ◽  
Author(s):  
Bernd Staubach ◽  
Joachim Buddrus
Keyword(s):  
Amino Acids ◽  
Nmr Spectroscopy ◽  
Palladium Compounds ◽  
Enantiomeric Ratio

31P NMR Spectroscopy as a Powerful Tool for the Determination of Enantiomeric Excess and Absolute Configurations of α-Amino Acids

2003 ◽  
Vol 42 (4) ◽  
pp. 1006-1013 ◽  
Author(s):  
Judith Bravo ◽  
Carlos Cativiela ◽  
Julio E. Chaves ◽  
Rafael Navarro ◽  
Esteban P. Urriolabeitia
Keyword(s):  
Amino Acids ◽  
Nmr Spectroscopy ◽  
31P Nmr ◽  
Enantiomeric Excess ◽  
31P Nmr Spectroscopy

Use of NMR spectroscopy in the analysis of carnosine and free amino acids in fermented sausages during ripening

2015 ◽  
Vol 69 (10) ◽  
Author(s):  
Marcel Mati ◽  
Ladislav Staruch ◽  
Michal Šoral
Keyword(s):  
Amino Acids ◽  
Nmr Spectroscopy ◽  
Free Amino Acids ◽  
Free Amino ◽  
High Fat ◽  
Nmr Method ◽  
Fermented Sausages ◽  
Quantitative Changes ◽  
First Time

AbstractQuantitative changes of carnosine and free amino acids in high-fat (43-50 mass %) fermented sausages during ripening were analysed using a 600 MHz VNMRS NMR spectrometer. Seven free amino acids were identified in the samples and a relatively high content of carnosine was observed in the final stage of ripening. The NMR method for the determination of free amino acids and carnosine content applied in this work has been used for the first time and it has proven to be suitable for the analysis of fermented sausages.

scholarly journals Synthesis and Structural Determination of Two New tri-Heterocyclic Regioisomeric Compounds, Precursors of Bi-Triazolic α-Amino Acids, via a Comparative Study using 1D NMR Spectroscopy

2020 ◽  
Vol 1 (6) ◽  
Author(s):  
S. Hajib ◽  
A. Alami ◽  
H. Faraj ◽  
A. Kaskas ◽  
Y. Aouine
Keyword(s):  
Amino Acids ◽  
Nmr Spectroscopy ◽  
Comparative Study ◽  
Spectroscopic Study ◽  
Cycloaddition Reaction ◽  
Structural Determination

In this article, we describe the synthesis of two new triheterocyclic regioisomers, named 4-({4-[(1H-1,2,4-triazol-1-yl)methyl]-1H-1,2,3-triazol-1-yl}methyl)-4-ethyl-2-phenyl-4,5-dihydrooxazole and 4-({5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-1,2,3-triazol-1-yl}methyl)-4-ethyl-2-phenyl-4,5-dihydrooxazole. The action of 1-(propargyl)-1H-1,2,4-triazole on 4-(azidomethyl)-4-ethyl-2-phenyl-4,5-dihydrooxazole, in a very small quantity of toluene, led after 48 hours at 120 °C to two regioisomers with an overall yield of 90%. The allocation of structures to these two regioisomers was carried out based on a comparative spectroscopic study using 1D NMR of the proton and carbon 13, as well as based on data from the literature concerning the cycloaddition reaction.

scholarly journals Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4548
Author(s):  
Claudine Nicole Herlan ◽  
Anna Sonnefeld ◽  
Thomas Gloge ◽  
Julian Brückel ◽  
Luisa Chiara Schlee ◽  
...  
Keyword(s):  
Amino Acids ◽  
Nmr Spectroscopy ◽  
Rational Design ◽  
Structural Investigation ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Proteolytic Degradation ◽  
X Ray ◽  
X Ray Scattering

Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic and medicinal research. However, their biological applicability is limited due to fast proteolytic degradation. The use of mimetic peptoids overcomes this disadvantage, though they lack stereochemical information at the α-carbon. Hybrids composed of amino acids and peptoid monomers combine the unique properties of both parent classes. Rigidification of the backbone increases the affinity towards various targets. However, only little is known about the spatial structure of such constrained hybrids. The determination of the three-dimensional structure is a key step for the identification of new targets as well as the rational design of bioactive compounds. Herein, we report the synthesis and the structural elucidation of novel tetrameric macrocycles. Measurements were taken in solid and solution states with the help of X-ray scattering and NMR spectroscopy. The investigations made will help to find diverse applications for this new, promising compound class.

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