scholarly journals Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate

2011 ◽  
Vol 124 (2) ◽  
pp. 460-464 ◽  
Author(s):  
Gang Liu ◽  
Ki Young Choi ◽  
Ashwinkumar Bhirde ◽  
Magdalena Swierczewska ◽  
Juan Yin ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Self Assembled

scholarly journals Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

2012 ◽  
Vol 7 (6) ◽  
pp. 389-393 ◽  
Author(s):  
Hyukjin Lee ◽  
Abigail K. R. Lytton-Jean ◽  
Yi Chen ◽  
Kevin T. Love ◽  
Angela I. Park ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Sirna Delivery ◽  
Self Assembled

scholarly journals Self-Assembled Cationic β-Cyclodextrin Nanostructures for siRNA Delivery

2019 ◽  
Vol 16 (3) ◽  
pp. 1358-1366 ◽  
Author(s):  
Raghvendra Pratap Singh ◽  
Tania Hidalgo ◽  
Pierre-Andre Cazade ◽  
Raphael Darcy ◽  
Michael F. Cronin ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Self Assembled

scholarly journals Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate

2011 ◽  
Vol 51 (2) ◽  
pp. 445-449 ◽  
Author(s):  
Gang Liu ◽  
Ki Young Choi ◽  
Ashwinkumar Bhirde ◽  
Magdalena Swierczewska ◽  
Juan Yin ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Self Assembled

Efficient Self‐Assembled DNA Nanoparticles through Rolling Circle Amplification for siRNA Delivery in v itro

2019 ◽  
Vol 37 (6) ◽  
pp. 588-592 ◽  
Author(s):  
Qian Yao ◽  
Yuqi Chen ◽  
Fan Wu ◽  
Fan Wu ◽  
Chaoxing Liu ◽  
...  
Keyword(s):  
Rolling Circle Amplification ◽  
Sirna Delivery ◽  
Rolling Circle ◽  
Dna Nanoparticles ◽  
Self Assembled

scholarly journals Self-assembled RNA interference microsponges for efficient siRNA delivery

2012 ◽  
Vol 11 (4) ◽  
pp. 316-322 ◽  
Author(s):  
Jong Bum Lee ◽  
Jinkee Hong ◽  
Daniel K. Bonner ◽  
Zhiyong Poon ◽  
Paula T. Hammond
Keyword(s):  
Rna Interference ◽  
Sirna Delivery ◽  
Self Assembled

scholarly journals Novel fusion peptide‐mediated siRNA delivery using self‐assembled nanocomplex

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yeong Chae Ryu ◽  
Kyung Ah Kim ◽  
Byoung Choul Kim ◽  
Hui-Min David Wang ◽  
Byeong Hee Hwang
Keyword(s):  
Gene Silencing ◽  
Cellular Uptake ◽  
Viral Infections ◽  
Immune Cell ◽  
Sirna Delivery ◽  
Cellular Membrane ◽  
Fusion Peptides ◽  
Self Assembled

Abstract Background Gene silencing using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments using siRNA essentially requires an efficient and safe method of delivering siRNA into cells while maintaining its stability. Thus, we designed novel synergistic fusion peptides, i.e., SPACE and oligoarginine. Results Among the novel fusion peptides and siRNAs, nanocomplexes have enhanced cellular uptake and gene silencing effect in vitro and improved retention and gene silencing effects of siRNAs in vivo. Oligoarginine could attract siRNAs electrostatically to form stable and self-assembled nanocomplexes, and the SPACE peptide could interact with the cellular membrane via hydrogen bonding. Therefore, nanocomplexes using fusion peptides showed improved and evident cellular uptake and gene silencing of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) via the lipid raft-mediated endocytosis pathway, especially to the HDFn cells of the skin, and all of the fusion peptides were biocompatible. Also, intratumorally injected nanocomplexes had increased retention time of siRNAs at the site of the tumor. Finally, nanocomplexes demonstrated significant in vivo gene silencing effect without overt tissue damage and immune cell infiltration. Conclusions The new nanocomplex strategy could become a safe and efficient platform for the delivery of siRNAs into cells and tissues to treat various target diseases through gene silencing.

Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery

Biomaterials ◽  
2008 ◽  
Vol 29 (32) ◽  
pp. 4348-4355 ◽  
Author(s):  
Tian-Meng Sun ◽  
Jin-Zhi Du ◽  
Li-Feng Yan ◽  
Hai-Quan Mao ◽  
Jun Wang
Keyword(s):  
Block Copolymer ◽  
Sirna Delivery ◽  
Self Assembled ◽  
Micellar Nanoparticles

Self-Assembled and Nanostructured siRNA Delivery Systems

2011 ◽  
Vol 28 (9) ◽  
pp. 2072-2085 ◽  
Author(s):  
Ji Hoon Jeong ◽  
Tae Gwan Park ◽  
Sun Hwa Kim
Keyword(s):  
Sirna Delivery ◽  
Delivery Systems ◽  
Self Assembled
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