scholarly journals Using Nonnatural Amino Acids to Control Metal-Coordination Number in Three-Stranded Coiled Coils

2006 ◽  
Vol 118 (18) ◽  
pp. 2930-2934 ◽  
Author(s):  
Kyung-Hoon Lee ◽  
Chris Cabello ◽  
Lars Hemmingsen ◽  
E. Neil G. Marsh ◽  
Vincent L. Pecoraro
Keyword(s):  
Amino Acids ◽  
Coordination Number ◽  
Coiled Coils ◽  
Metal Coordination ◽  
Nonnatural Amino Acids

scholarly journals Using Nonnatural Amino Acids to Control Metal-Coordination Number in Three-Stranded Coiled Coils

2006 ◽  
Vol 45 (18) ◽  
pp. 2864-2868 ◽  
Author(s):  
Kyung-Hoon Lee ◽  
Chris Cabello ◽  
Lars Hemmingsen ◽  
E. Neil G. Marsh ◽  
Vincent L. Pecoraro
Keyword(s):  
Amino Acids ◽  
Coordination Number ◽  
Coiled Coils ◽  
Metal Coordination ◽  
Nonnatural Amino Acids

scholarly journals Diverse protein assembly driven by metal and chelating amino acids with selectivity and tunability

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Minwoo Yang ◽  
Woon Ju Song
Keyword(s):  
Amino Acids ◽  
Self Assembly ◽  
Protein Structures ◽  
Functional Materials ◽  
Building Blocks ◽  
Unnatural Amino Acid ◽  
Metal Coordination ◽  
Specific Chemical ◽  
Natural Building ◽  
Kinetics Of

AbstractProteins are versatile natural building blocks with highly complex and multifunctional architectures, and self-assembled protein structures have been created by the introduction of covalent, noncovalent, or metal-coordination bonding. Here, we report the robust, selective, and reversible metal coordination properties of unnatural chelating amino acids as the sufficient and dominant driving force for diverse protein self-assembly. Bipyridine-alanine is genetically incorporated into a D3 homohexamer. Depending on the position of the unnatural amino acid, 1-directional, crystalline and noncrystalline 2-directional, combinatory, and hierarchical architectures are effectively created upon the addition of metal ions. The length and shape of the structures is tunable by altering conditions related to thermodynamics and kinetics of metal-coordination and subsequent reactions. The crystalline 1-directional and 2-directional biomaterials retain their native enzymatic activities with increased thermal stability, suggesting that introducing chelating ligands provides a specific chemical basis to synthesize diverse protein-based functional materials while retaining their native structures and functions.

scholarly journals In vitro incorporation of nonnatural amino acids into protein using tRNACys-derived opal, ochre, and amber suppressor tRNAs

RNA ◽  
2010 ◽  
Vol 16 (8) ◽  
pp. 1660-1672 ◽  
Author(s):  
J. Gubbens ◽  
S. J. Kim ◽  
Z. Yang ◽  
A. E. Johnson ◽  
W. R. Skach
Keyword(s):  
Amino Acids ◽  
Nonnatural Amino Acids ◽  
Amber Suppressor

Binding of Amino Acids with a Bifunctional Metalloporphyrin via Concurrent Metal-Coordination and Electrostatic Interactions

1989 ◽  
Vol 18 (10) ◽  
pp. 1877-1880 ◽  
Author(s):  
Yasuhiro Aoyama ◽  
Shin-ichi Nonaka ◽  
Tadahiro Motomura ◽  
Hisanobu Ogoshi
Keyword(s):  
Amino Acids ◽  
Electrostatic Interactions ◽  
Metal Coordination

Incorporation of Two Different Nonnatural Amino Acids Independently into a Single Protein through Extension of the Genetic Code

1999 ◽  
Vol 121 (51) ◽  
pp. 12194-12195 ◽  
Author(s):  
Takahiro Hohsaka ◽  
Yuki Ashizuka ◽  
Hiroshi Sasaki ◽  
Hiroshi Murakami ◽  
Masahiko Sisido
Keyword(s):  
Amino Acids ◽  
Genetic Code ◽  
Nonnatural Amino Acids ◽  
Single Protein
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