Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in down syndrome: Quantitative comparison with alzheimer dementia

1980 ◽  
Vol 7 (5) ◽  
pp. 462-465 ◽  
Author(s):  
M. J. Ball ◽  
K. Nuttall
Keyword(s):  
Down Syndrome ◽  
Neurofibrillary Tangles ◽  
Quantitative Comparison ◽  
Granulovacuolar Degeneration ◽  
Neuron Loss ◽  
Alzheimer Dementia

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 ◽  
Vol 125 (4) ◽  
pp. 489-492 ◽  
Author(s):  
Kymberly A. Gyure ◽  
Robert Durham ◽  
Walter F. Stewart ◽  
John E. Smialek ◽  
Juan C. Troncoso
Keyword(s):  
Down Syndrome ◽  
Alzheimer Disease ◽  
Neurofibrillary Tangles ◽  
Senile Plaques ◽  
Medical Examiner ◽  
Johns Hopkins Hospital ◽  
Sequence Of Events ◽  
Amyloid Deposits ◽  
Aβ Amyloid ◽  
Intraneuronal Aβ

Abstract Context.—Down syndrome patients who live to middle age invariably develop the neuropathologic features of Alzheimer disease, providing a unique situation in which to study the early and sequential development of these changes. Objective.—To study the development of amyloid deposits, senile plaques, astrocytic and microglial reactions, and neurofibrillary tangles in the brains of young individuals (<30 years of age) with Down syndrome. Methods.—Histologic and immunocytochemical study of a series of autopsy brains (n = 14, from subjects aged 11 months to 56 years, with 9 subjects <30 years) examined at the Office of the Chief Medical Examiner of the State of Maryland and The Johns Hopkins Hospital. Results.—The principal observations included the presence of intraneuronal Aβ immunostaining in the hippocampus and cerebral cortex of very young Down syndrome patients (preceding the extracellular deposition of Aβ) and the formation of senile plaques and neurofibrillary tangles. Conclusions.—We propose the following sequence of events in the development of neuropathologic changes of Alzheimer disease in Down syndrome: (1) intracellular accumulation of Aβ in neurons and astrocytes, (2) deposition of extracellular Aβ and formation of diffuse plaques, and (3) development of neuritic plaques and neurofibrillary tangles with activation of microglial cells.

NEUROFIBRILLARY TANGLES PRECEDE AMYLOID PLAQUES IN DOWN SYNDROME

1990 ◽  
Vol 49 (3) ◽  
pp. 265
Author(s):  
E. H. Bigio ◽  
D. R. Sparkman ◽  
A. W. Clark ◽  
C. L. White
Keyword(s):  
Down Syndrome ◽  
Neurofibrillary Tangles ◽  
Amyloid Plaques

scholarly journals Preferential 3‐repeat tau staining of extracellular neurofibrillary tangles in Down syndrome with Alzheimer type changes

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Kathleen M. Enstice ◽  
Christa L. Hladik ◽  
Ping Shang ◽  
Charles L. White
Keyword(s):  
Down Syndrome ◽  
Neurofibrillary Tangles ◽  
Alzheimer Type

scholarly journals Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Kristen E. Funk ◽  
Jeff Kuret
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Neurofibrillary Tangles ◽  
Recent Literature ◽  
Senile Plaques ◽  
Disease Onset ◽  
Granulovacuolar Degeneration

Alzheimer's disease is characterized pathologically by extracellular senile plaques, intracellular neurofibrillary tangles, and granulovacuolar degeneration. It has been debated whether these hallmark lesions are markers or mediators of disease progression, and numerous paradigms have been proposed to explain the appearance of each lesion individually. However, the unfaltering predictability of these lesions suggests a single pathological nidus central to disease onset and progression. One of the earliest pathologies observed in Alzheimer's disease is endocytic dysfunction. Here we review the recent literature of endocytic dysfunction with particular focus on disrupted lysosomal fusion and propose it as a unifying hypothesis for the three most-studied lesions of Alzheimer's disease.

Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes

1987 ◽  
Vol 73 (3) ◽  
pp. 240-246 ◽  
Author(s):  
J. Ulrich ◽  
M. Haugh ◽  
B. H. Anderton ◽  
A. Probst ◽  
C. Lautenschlager ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Pick Bodies ◽  
Alzheimer Dementia

scholarly journals Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Sally Hunter ◽  
◽  
Thais Minett ◽  
Tuomo Polvikoski ◽  
Elizabeta Mukaetova-Ladinska ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Granulovacuolar Degeneration
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