Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis

2006 ◽  
Vol 59 (3) ◽  
pp. 566-569 ◽  
Author(s):  
Brian G. Weinshenker ◽  
Dean M. Wingerchuk ◽  
Sandra Vukusic ◽  
Linda Linbo ◽  
Sean J. Pittock ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Extensive Transverse Myelitis

Occurrence of acute large and edematous callosal lesions in neuromyelitis optica

2009 ◽  
Vol 15 (6) ◽  
pp. 695-700 ◽  
Author(s):  
M Nakamura ◽  
T Misu ◽  
K Fujihara ◽  
I Miyazawa ◽  
I Nakashima ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Medical Records ◽  
Brain Magnetic Resonance Imaging ◽  
Transverse Myelitis ◽  
Resonance Imaging ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Lower Margin ◽  
Chronic Stage ◽  
The Brain ◽  
Extensive Transverse Myelitis

Background The corpus callosum is commonly involved in multiple sclerosis (MS), but the characteristics of callosal lesions in neuromyelitis optica (NMO) are unknown. Objective To reveal the features of callosal lesions in NMO in comparison to MS. Methods We retrospectively reviewed the medical records and the brain magnetic resonance imaging films of 56 patients with MS and 22 patients with NMO. Results In MS, 36 (64.3%) of 56 patients had callosal lesions, but only four patients had acute lesions. All such acute lesions were small, isolated and non-edematous, and the intensity was homotonic. Chronic lesions were observed in 34 patients with MS, and 32 (94%) of them presented small lesions located at the callosal lower margin (“hemi-oval pattern”). Meanwhile, four (18.2%) patients with NMO had callosal lesions, and three of them had acute lesions. Those acute lesions were multiple, large edematous ones with heterogeneous intensity (“marbled pattern”). In the chronic stage, the lesions shrank or disappeared. Conclusions Acute large, edematous callosal lesions occasionally occur in NMO. Similar to longitudinally extensive transverse myelitis, such callosal lesions may reflect severe edematous inflammation in NMO, and may provide additional evidence that the pathogenesis in NMO is different from that in MS.

scholarly journals Pulmonary Tuberculosis with Longitudinally Extensive Transverse Myelitis

2020 ◽  
Vol 11 (01) ◽  
pp. 178-182
Author(s):  
Kiran Kumar Ramineni ◽  
Ravi Kanth Jakkani ◽  
B. V. G. Swamy ◽  
Sravan Kumar M.
Keyword(s):  
Pulmonary Tuberculosis ◽  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Good Recovery ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Active Pulmonary Tuberculosis ◽  
Rare Phenomenon ◽  
Spectrum Disorders ◽  
Extensive Transverse Myelitis

AbstractLongitudinally extensive transverse myelitis (LETM) is described in neuromyelitis optica spectrum disorders. Simultaneous active pulmonary tuberculosis in these disorders is a relatively rare phenomenon. We report a 16 year-old boy diagnosed as LETM with clinicoradiological correlation. Further evaluation revealed active pulmonary tuberculosis. He had good recovery following the combination of antituberculosis regimen with corticosteroids.

Neuromyelitis optica spectrum disorders: beyond longitudinally extensive transverse myelitis

2015 ◽  
Vol 70 (6) ◽  
pp. 630-637 ◽  
Author(s):  
M.D. Lemos ◽  
G.B.S. Carvalho ◽  
R.S. Carvalho ◽  
D.B. Bichuetti ◽  
E.M.L. de Oliveira ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Spectrum Disorders ◽  
Extensive Transverse Myelitis

scholarly journals The expanded spectrum of neuromyelitis optica: evidences for a new definition

2012 ◽  
Vol 70 (10) ◽  
pp. 807-813 ◽  
Author(s):  
Marco A Lana-Peixoto ◽  
Dagoberto Callegaro
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Brain Mri ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Index Event ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

Neuromyelitis optica (NMO) has been traditionally described as the association of recurrent or bilateral optic neuritis and longitudinally extensive transverse myelitis (LETM). Identification of aquaporin-4 antibody (AQP4-IgG) has deeply changed the concept of NMO. A spectrum of NMO disorders (NMOSD) has been formulated comprising conditions which include both AQP4-IgG seropositivity and one of the index events of the disease (recurrent or bilateral optic neuritis and LETM). Most NMO patients harbor asymptomatic brain MRI lesions, some of them considered as typical of NMO. Some patients with aquaporin-4 autoimmunity present brainstem, hypothalamic or encephalopathy symptoms either preceding an index event or occurring isolatedly with no evidence of optic nerve or spinal involvement. On the opposite way, other patients have optic neuritis or LETM in association with typical lesions of NMO on brain MRI and yet are AQP4-IgG seronegative. An expanded spectrum of NMO disorders is proposed to include these cases.

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