scholarly journals MRI Features of Aquaporin-4 Antibody–Positive Longitudinally Extensive Transverse Myelitis: Insights into the Diagnosis of Neuromyelitis Optica Spectrum Disorders

2018 ◽  
Vol 39 (4) ◽  
pp. 782-787 ◽  
Author(s):  
C.G. Chee ◽  
K.S. Park ◽  
J.W. Lee ◽  
H.W. Ahn ◽  
E. Lee ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Mri Features ◽  
Spectrum Disorders ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

scholarly journals Pulmonary Tuberculosis with Longitudinally Extensive Transverse Myelitis

2020 ◽  
Vol 11 (01) ◽  
pp. 178-182
Author(s):  
Kiran Kumar Ramineni ◽  
Ravi Kanth Jakkani ◽  
B. V. G. Swamy ◽  
Sravan Kumar M.
Keyword(s):  
Pulmonary Tuberculosis ◽  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Good Recovery ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Active Pulmonary Tuberculosis ◽  
Rare Phenomenon ◽  
Spectrum Disorders ◽  
Extensive Transverse Myelitis

AbstractLongitudinally extensive transverse myelitis (LETM) is described in neuromyelitis optica spectrum disorders. Simultaneous active pulmonary tuberculosis in these disorders is a relatively rare phenomenon. We report a 16 year-old boy diagnosed as LETM with clinicoradiological correlation. Further evaluation revealed active pulmonary tuberculosis. He had good recovery following the combination of antituberculosis regimen with corticosteroids.

Neuromyelitis optica spectrum disorders: beyond longitudinally extensive transverse myelitis

2015 ◽  
Vol 70 (6) ◽  
pp. 630-637 ◽  
Author(s):  
M.D. Lemos ◽  
G.B.S. Carvalho ◽  
R.S. Carvalho ◽  
D.B. Bichuetti ◽  
E.M.L. de Oliveira ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Spectrum Disorders ◽  
Extensive Transverse Myelitis

scholarly journals The expanded spectrum of neuromyelitis optica: evidences for a new definition

2012 ◽  
Vol 70 (10) ◽  
pp. 807-813 ◽  
Author(s):  
Marco A Lana-Peixoto ◽  
Dagoberto Callegaro
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Brain Mri ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Index Event ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

Neuromyelitis optica (NMO) has been traditionally described as the association of recurrent or bilateral optic neuritis and longitudinally extensive transverse myelitis (LETM). Identification of aquaporin-4 antibody (AQP4-IgG) has deeply changed the concept of NMO. A spectrum of NMO disorders (NMOSD) has been formulated comprising conditions which include both AQP4-IgG seropositivity and one of the index events of the disease (recurrent or bilateral optic neuritis and LETM). Most NMO patients harbor asymptomatic brain MRI lesions, some of them considered as typical of NMO. Some patients with aquaporin-4 autoimmunity present brainstem, hypothalamic or encephalopathy symptoms either preceding an index event or occurring isolatedly with no evidence of optic nerve or spinal involvement. On the opposite way, other patients have optic neuritis or LETM in association with typical lesions of NMO on brain MRI and yet are AQP4-IgG seronegative. An expanded spectrum of NMO disorders is proposed to include these cases.

scholarly journals Neuropathic pruritus: an early indicator of neuromyelitis optica spectrum disorders

2018 ◽  
Vol 6 (8) ◽  
pp. 2867
Author(s):  
Pradeep Kumar Bansal ◽  
C. L. Nawal ◽  
Aradhana Singh ◽  
Radheyshyam Chejara ◽  
Sebastian Marker ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Chief Complaints ◽  
Neuropathic Pruritus ◽  
Spectrum Disorders ◽  
Tonic Spasms ◽  
Extensive Transverse Myelitis

Neuromyelitis optica is a relapsing, inflammatory astrocytopathic disorder, affecting predominantly the optic nerves and spinal cord. It is associated with antiaquaporin-4 immunoglobulin G (AQP4-IgG) in up to 70% of patients. Spinal cord involvement typically presents as a longitudinally-extensive transverse myelitis, with associated sensorimotor and sphincter dysfunction. Sensory symptoms such as numbness, dysaesthesia, pain and tonic spasms are common. Here, we present a case of a 25years old female who came to the medicine OPD, with the chief complaints of intense itching over face and forehead, which was later on progressed to quadriparesis after 3 weeks. This case highlights neuropathic pruritus as an under-recognised early feature of neuromyelitis optica.

scholarly journals Peripapillary and parafoveal vascular network assessment by optical coherence tomography angiography in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders

2018 ◽  
Vol 103 (6) ◽  
pp. 789-796 ◽  
Author(s):  
Yongheng Huang ◽  
Lei Zhou ◽  
Jingzi ZhangBao ◽  
Tongjia Cai ◽  
Bei Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Neuromyelitis Optica ◽  
Vessel Density ◽  
Aquaporin 4 ◽  
Optical Coherence ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectral Domain Oct ◽  
History Of ◽  
Spectrum Disorders ◽  
Aquaporin 4 Antibody

Background/aimsCurrent understanding of the alterations in the retinal vascular network in neuromyelitis optica spectrum disorders (NMOSDs) is limited. We aim to assess the peripapillary and parafoveal vessel density in aquaporin-4 antibody-positive NMOSD patients by optical coherence tomography (OCT) angiography.MethodsA total of 55 aquaporin-4 antibody-positive NMOSD patients with or without a history of optic neuritis (ON) and 33 healthy controls underwent spectral domain OCT and OCT angiography. Clinical histories, Expanded Disability Status Scale score, visual functional system score (VFSS) and disease duration were collected.ResultsPeripapillary and parafoveal vessel density was significantly decreased in NMOSD eyes with or without a history of ON. The decrease in retinal vessel density could occur before ON and retinal nerve fibre layer (RNFL) atrophy. Peripapillary vessel density correlated well with the spectral domain OCT measurements and VFSS in NMOSD eyes with a history of ON.ConclusionSubclinical primary retinal vasculopathy may occur in NMOSD prior to ON and RNFL atrophy. Peripapillary vessel density might be a sensitive predictor of visual outcomes in NMOSD patients with ON.

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