Changes of sodium channel expression in experimental painful diabetic neuropathy

2002 ◽  
Vol 52 (6) ◽  
pp. 786-792 ◽  
Author(s):  
Matthew J. Craner ◽  
Joshua P. Klein ◽  
Muthukrishnan Renganathan ◽  
Joel A. Black ◽  
Stephen G. Waxman
Keyword(s):  
Diabetic Neuropathy ◽  
Sodium Channel ◽  
Painful Diabetic Neuropathy ◽  
Channel Expression

scholarly journals Reduction of Voltage Gated Sodium Channel Protein in DRG by Vector Mediated miRNA Reduces Pain in Rats with Painful Diabetic Neuropathy

2012 ◽  
Vol 8 ◽  
pp. 1744-8069-8-17 ◽  
Author(s):  
Munmun Chattopadhyay ◽  
Zhigang Zhou ◽  
Shuanglin Hao ◽  
Marina Mata ◽  
David J Fink
Keyword(s):  
Diabetic Neuropathy ◽  
Sodium Channel ◽  
Painful Diabetic Neuropathy ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Channel Protein

scholarly journals Optimal Utility of H-Reflex RDD as a Biomarker of Spinal Disinhibition in Painful and Painless Diabetic Neuropathy

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1247
Author(s):  
Anne Worthington ◽  
Alise Kalteniece ◽  
Maryam Ferdousi ◽  
Luca Donofrio ◽  
Shaishav Dhage ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Initial Response ◽  
Healthy Controls ◽  
Painful Diabetic Neuropathy ◽  
Stimulus Response ◽  
Rate Dependent ◽  
Potential Biomarker ◽  
Spinal Inhibition

Impaired rate-dependent depression of the Hoffman reflex (HRDD) is a potential biomarker of impaired spinal inhibition in patients with painful diabetic neuropathy. However, the optimum stimulus-response parameters that identify patients with spinal disinhibition are currently unknown. We systematically compared HRDD, performed using trains of 10 stimuli at five stimulation frequencies (0.3, 0.5, 1, 2 and 3 Hz), in 42 subjects with painful and 62 subjects with painless diabetic neuropathy with comparable neuropathy severity, and 34 healthy controls. HRDD was calculated using individual and mean responses compared to the initial response. At stimulation frequencies of 1, 2 and 3 Hz, HRDD was significantly impaired in patients with painful diabetic neuropathy compared to patients with painless diabetic neuropathy for all parameters and for most parameters when compared to healthy controls. HRDD was significantly enhanced in patients with painless diabetic neuropathy compared to controls for responses towards the end of the 1 Hz stimulation train. Receiver operating characteristic curve analysis in patients with and without pain showed that the area under the curve was greatest for response averages of stimuli 2–4 and 2–5 at 1 Hz, AUC = 0.84 (95%CI 0.76–0.92). Trains of 5 stimuli delivered at 1 Hz can segregate patients with painful diabetic neuropathy and spinal disinhibition, whereas longer stimulus trains are required to segregate patients with painless diabetic neuropathy and enhanced spinal inhibition.

Sign in / Sign up

Export Citation Format

Share Document