The Effect and Molecular Mechanism of Pancreatic Kallikrein in Painful Diabetic Neuropathy Based on CX3CL1/CX3CR1 Pathway

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 557-P
Author(s):  
XU XIANG ◽  
JIN HUI ◽  
XU LAN
Keyword(s):  
Diabetic Neuropathy ◽  
Molecular Mechanism ◽  
Painful Diabetic Neuropathy

scholarly journals Optimal Utility of H-Reflex RDD as a Biomarker of Spinal Disinhibition in Painful and Painless Diabetic Neuropathy

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1247
Author(s):  
Anne Worthington ◽  
Alise Kalteniece ◽  
Maryam Ferdousi ◽  
Luca Donofrio ◽  
Shaishav Dhage ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Initial Response ◽  
Healthy Controls ◽  
Painful Diabetic Neuropathy ◽  
Stimulus Response ◽  
Rate Dependent ◽  
Potential Biomarker ◽  
Spinal Inhibition

Impaired rate-dependent depression of the Hoffman reflex (HRDD) is a potential biomarker of impaired spinal inhibition in patients with painful diabetic neuropathy. However, the optimum stimulus-response parameters that identify patients with spinal disinhibition are currently unknown. We systematically compared HRDD, performed using trains of 10 stimuli at five stimulation frequencies (0.3, 0.5, 1, 2 and 3 Hz), in 42 subjects with painful and 62 subjects with painless diabetic neuropathy with comparable neuropathy severity, and 34 healthy controls. HRDD was calculated using individual and mean responses compared to the initial response. At stimulation frequencies of 1, 2 and 3 Hz, HRDD was significantly impaired in patients with painful diabetic neuropathy compared to patients with painless diabetic neuropathy for all parameters and for most parameters when compared to healthy controls. HRDD was significantly enhanced in patients with painless diabetic neuropathy compared to controls for responses towards the end of the 1 Hz stimulation train. Receiver operating characteristic curve analysis in patients with and without pain showed that the area under the curve was greatest for response averages of stimuli 2–4 and 2–5 at 1 Hz, AUC = 0.84 (95%CI 0.76–0.92). Trains of 5 stimuli delivered at 1 Hz can segregate patients with painful diabetic neuropathy and spinal disinhibition, whereas longer stimulus trains are required to segregate patients with painless diabetic neuropathy and enhanced spinal inhibition.

scholarly journals Effective Pharmacological Treatment of Painful Diabetic Neuropathy by Nurse Practitioners: Results of an Algorithm-Based Experience

Pain Medicine ◽  
2012 ◽  
Vol 13 (10) ◽  
pp. 1324-1333 ◽  
Author(s):  
Margot Geerts ◽  
Sabine A. N. T. Landewé-Cleuren ◽  
Marleen Kars ◽  
Hubertus J. M. Vrijhoef ◽  
Nicolaas C. Schaper
Keyword(s):  
Diabetic Neuropathy ◽  
Nurse Practitioners ◽  
Pharmacological Treatment ◽  
Painful Diabetic Neuropathy

Patient Compliance With SSRIs and Gabapentin in Painful Diabetic Neuropathy

2007 ◽  
Vol 23 (3) ◽  
pp. 267-269 ◽  
Author(s):  
Sotirios Giannopoulos ◽  
Maria Kosmidou ◽  
Ioannis Sarmas ◽  
Sofia Markoula ◽  
Sigliti-Henrietta Pelidou ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Patient Compliance ◽  
Painful Diabetic Neuropathy
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