scholarly journals Thyroid storm associated with type 2 amiodarone‐induced thyrotoxicosis due to long‐term administration: a case report

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Kiyoshi Takemoto ◽  
Shimon Takada
Keyword(s):  
Case Report ◽  
Thyroid Storm ◽  
Term Administration

scholarly journals Cardiovascular Effects of Long-Term Central and Peripheral Administration of Urocortin, Corticotropin-Releasing Factor, and Adrenocorticotropin in Sheep

Endocrinology ◽  
2004 ◽  
Vol 145 (12) ◽  
pp. 5598-5604 ◽  
Author(s):  
R. S. Weisinger ◽  
J. R. Blair-West ◽  
P. Burns ◽  
D. A. Denton ◽  
B. Purcell ◽  
...  
Keyword(s):  
Stress Response ◽  
Arterial Pressure ◽  
Cardiovascular Effects ◽  
Corticotropin Releasing Factor ◽  
Central Administration ◽  
Long Term Effects ◽  
Cardiovascular Actions ◽  
Term Administration

Abstract The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term infusions of these hormones, both peripherally and centrally, in conscious animals have not been studied. Knowledge of the long-term effects is important because they may differ considerably from their acute actions, and stress is frequently a chronic stimulus. The present experiments investigated the cardiovascular effects of CRF, UCN, and ACTH in conscious sheep. Infusions were made either into the lateral cerebral ventricles (icv) or iv over 4 d at 5 μg/h. UCN infused icv or iv caused a prolonged increase in heart rate (HR) (P < 0.01) and a small increase in mean arterial pressure (MAP) (P < 0.05). CRF infused icv or iv progressively increased MAP (P < 0.05) but had no effect on HR. Central administration of ACTH had no effect, whereas systemic infusion increased MAP and HR (P < 0.001). In conclusion, long-term administration of these three peptides associated with the stress response had prolonged, selective cardiovascular actions. The striking finding was the large and sustained increase in HR with icv and iv infusions of UCN. These responses are probably mediated by CRF type 2 receptors because they were not reproduced by infusions of CRF.

Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus

2003 ◽  
Vol 285 (6) ◽  
pp. H2392-H2398 ◽  
Author(s):  
Joshua A. Beckman ◽  
Allison B. Goldfine ◽  
Mary Beth Gordon ◽  
Leslie A. Garrett ◽  
John F. Keaney ◽  
...  
Keyword(s):  
Antioxidant Therapy ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Vascular Ultrasonography ◽  
Term Administration ◽  
Healthy Control ◽  
To Receive

Oxidative stress decreases the bioavailability of endothelium-derived nitric oxide in diabetic patients. We investigated whether impaired endothelium-dependent vasodilation (EDV) in diabetes can be improved by long-term administration of oral antioxidants. Forty-nine diabetic subjects [26 Type 1 (T1) and 23 Type 2 (T2)] and 45 matched healthy control subjects were randomized to receive oral vitamin C (1,000 mg) and vitamin E (800 IU) daily or matching placebo for 6 mo. Vascular ultrasonography was used to determine brachial artery EDV and endothelium-independent vasodilation (EIV). EDV was decreased in both T1 (4.9 ± 0.9%, P = 0.015) and T2 (4.1 ± 1.0%, P < 0.01) subjects compared with control subjects (7.7 ± 0.7%). EIV was decreased in T2 (15.0 ± 1.2%, P < 0.01) but not T1 subjects (18.5 ± 2.3%, P = 0.3) compared with controls (21.8 ± 1.8%). Administration of antioxidant vitamins increased EDV in T1 (by 3.4 ± 1.4%, P = 0.023) but not T2 subjects (by 0.5. ± 0.4%, P = 0.3). Antioxidant therapy had no signigicant affect on EIV. Oral antioxidant therapy improves EDV in T1 but not T2 diabetes. These results are consistent with the lack of clinical benefit in studies that have included primarily T2 diabetic patients.

Liver cirrhosis resulting from long-term administration of S-1 for treatment of acinar cell carcinoma of the pancreas: A case report

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S175
Author(s):  
Naoki Yoshida ◽  
Atsushi Kanno ◽  
Atsushi Masamune ◽  
Seiji Hongo ◽  
Eriko Nakano ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Case Report ◽  
Cell Carcinoma ◽  
Acinar Cell ◽  
Acinar Cell Carcinoma ◽  
Carcinoma Of The Pancreas ◽  
Term Administration

scholarly journals Remission of type 2 diabetes in a young, hypogonadal man under long-term testosterone therapy: A case report

2020 ◽  
Vol 7 (2) ◽  
pp. 024-028
Author(s):  
Mskhalaya George ◽  
Tishova Yulia ◽  
Alfaradzh Anas ◽  
Kalinchenko Svetlana
Keyword(s):  
Type 2 Diabetes ◽  
Case Report ◽  
Testosterone Therapy

scholarly journals A Case Report :Alprazolam Therapy in A Dextra Fronto-Parietal Meningioma Patient With Anxiety Disorders

2021 ◽  
Vol 4 (1) ◽  
pp. 41-45
Author(s):  
Prajogo Wibowo ◽  
Prawesty Diah Utami
Keyword(s):  
Case Report ◽  
Anxiety Disorders ◽  
Panic Attacks ◽  
Primary Concern ◽  
Patient Anxiety ◽  
Rebound Effects ◽  
Normal Ranges ◽  
Term Administration ◽  
The Right

Meningiomas in the frontoparietal lobe may cause anxiety disorders and panic attacks. While alprazolam is one of the most widely used medications for anxiety disorders, long-term use may result in adverse side effects (withdrawal and rebound effects). This case study aims to describe the efficacy of long-term alprazolam administration in patients with meningiomas for regulating anxiety disorders. Case report :The asymmetrical face is the primary concern of a 65-year-old female when she is anxious. The results of the physical assessment and laboratory tests are within normal ranges. However, The HARS procedure showed moderate anxiety, and the CT scan revealed a meningioma in the right frontoparietal lobe. To regulate patient anxiety disorders, doctors give alprazolam 0.5 mg per day single dose for 4 months and tapering off for 3 months. Conclusion: Long-term administration of alprazolam in these patients can reduce the patient's anxiety disorder without causing withdrawal or rebound effects. A low dosage of alprazolam, a mild level of anxiety illness, and a slow tapering off phase were factors that contributed to the effectiveness of alprazolam treatment to suppress anxiety symptoms in this situation.

scholarly journals Low-Molecular-Weight NGF Mimetic Corrects the Cognitive Deficit and Depression-like Behavior in Experimental Diabetes

Acta Naturae ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 94-102 ◽  
Author(s):  
R. U. Ostrovskaya ◽  
S. S. Yagubova ◽  
T. A. Gudasheva ◽  
S. B. Seredenin
Keyword(s):  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Learning Ability ◽  
Neuroprotective Activity ◽  
Morris Water Maze Test ◽  
Term Administration ◽  
Pancreatic Beta Cell Function

Based on the comorbidity of diabetes, depression, and dementia and recognizing that a deficiency of the nerve growth factor (NGF) is involved in all of these kinds of pathologies, we studied the effect of the mimetic of dimeric dipeptide NGF loop 4, GK-2, on a model of streptozotocin-induced type 2 diabetes in C57Bl/6 mice. GK-2 [hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine)] was synthesized at the V.V. Zakusov Scientific Research Institute of Pharmacology. The study revealed the ability of GK-2 to ameliorate hyperglycemia induced by streptozotocine (STZ 100 mg/kg i.p.) in C57Bl/6 mice, to restore learning ability in the Morris Water Maze test, and to overcome depression after both intraperitoneal (0.5 mg/kg) and peroral (5 mg/kg) long-term administration. The presence of the listed properties and their preservation in the case of peroral treatment determines the prospects of research. Taking into account the previous findings on the ability of GK-2 to selectively activate PI3K/Akt, these data suggest that Akt-signaling is sufficient for pancreatic beta cell function. GK-2 has been shown to exhibit pronounced neuroprotective activity. The coexistence of neuroprotective and antidiabetic effects is in agreement with the fundamental concept holding that the function of neurons and pancreatic beta cells is controlled by similar mechanisms.

Efficacy and Safety of Long-Term Administration of Dapagliflozin for Japanese Patients with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1180-P
Author(s):  
MASAHIRO YAMAZAKI ◽  
RYOSUKE SAKAI ◽  
TAKURO OKAMURA ◽  
MICHIAKI FUKUI
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Japanese Patients ◽  
Efficacy And Safety ◽  
Term Administration
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