scholarly journals Long-term administration of angiotensin (1⿿7) prevents heart and lung dysfunction in a mouse model of type 2 diabetes ( db/db ) by reducing oxidative stress, inflammation and pathological remodeling

2016 ◽  
Vol 107 ◽  
pp. 372-380 ◽  
Author(s):  
Anna M. Papinska ◽  
Maira Soto ◽  
Christopher J. Meeks ◽  
Kathleen E. Rodgers
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Mouse Model ◽  
Lung Dysfunction ◽  
Term Administration ◽  
Pathological Remodeling

scholarly journals L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 793
Author(s):  
Cheng Schwank-Xu ◽  
Elisabete Forsberg ◽  
Magnus Bentinger ◽  
Allan Zhao ◽  
Ishrath Ansurudeen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Mouse Model ◽  
Mitochondrial Function ◽  
Diabetes Complications ◽  
Synergistic Effects ◽  
Coenzyme Q ◽  
Protective Effects ◽  
Beneficial Effects

Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and diabetes complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing and kidney function in animal models of type 2 diabetes. Coenzyme Q (CoQ), a component of the mitochondrial electron transport chain, possesses similar protective effects on diabetes complications. We aimed to study the effect of carnosine on CoQ, and assess any synergistic effects of carnosine and CoQ on improved mitochondrial function in a mouse model of type 2 diabetes. Carnosine enhanced CoQ gene expression and increased hepatic CoQ biosynthesis in db/db mice, a type 2 diabetes model. Co-administration of Carnosine and CoQ improved mitochondrial function, lowered ROS formation and reduced signs of oxidative stress. Our work suggests that carnosine exerts beneficial effects on hepatic CoQ synthesis and when combined with CoQ, improves mitochondrial function and cellular redox balance in the liver of diabetic mice. (4) Conclusions: L-carnosine has beneficial effects on oxidative stress both alone and in combination with CoQ on hepatic mitochondrial function in an obese type 2 diabetes mouse model.

Efficacy and Safety of Long-Term Administration of Dapagliflozin for Japanese Patients with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1180-P
Author(s):  
MASAHIRO YAMAZAKI ◽  
RYOSUKE SAKAI ◽  
TAKURO OKAMURA ◽  
MICHIAKI FUKUI
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Japanese Patients ◽  
Efficacy And Safety ◽  
Term Administration

scholarly journals Long-term use of dipeptyl peptidase-4 inhibitors suppresses systemic oxidative stress in rats with type 2 diabetes

2019 ◽  
Vol 10 (4) ◽  
pp. 21-30
Author(s):  
S. S. Bolevich ◽  
P. F. Litvitsky ◽  
V. Jakovljevic ◽  
S. B. Bolevich
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Hydrogen Peroxide ◽  
Superoxide Radical ◽  
Reduced Glutathione ◽  
Systemic Oxidative Stress ◽  
Group 2 ◽  
Group 1

Induction of oxidative stress is one of the main mechanisms responsible for the development of micro- and macrovascular angiopathy in patients with type 2 diabetes mellitus (DM-2).Aim. To evaluate the influence of long-term treatment with inhibitors of dipeptidyl peptidase-4 (DPP-4) on the characteristics of oxidative stress and the state of antioxidant defense system in rats with induced DM 2.Materials and methods. We divided 60 Wistar albino rats into 5 groups: group 1 (control) – normal animals; groups 2–5 rats with DM 2, induced by streptozotocin: group 2 – without treatment with DPP 4; group 3 – rats, treated with saxagliptin (0.45 mg/kg); group 4 – rats, treated with sitagliptin for 3 weeks (0.6 mg/kg); group 5 – rats, treated with vildagliptin (9 mg/kg). At the end of the experimental phase we determined the level of superoxide anion radical (O2-), hydrogen peroxide (H2O2), nitrite (NO2-), reduced glutathione, as well as the activity of catalase and superoxide dismutase (SOD) in the blood of rats using a diode array spectrophotometer.Results. Induction of DM-2 in experimental animals led to a significant increase of reactive oxygen species (ROS): superoxide radical and hydrogen peroxide and to decrease in NO2-, reduced glutathione, catalase and SOD activity. Comparing groups 3–5 with group 2, treatment with DPP-4 inhibitors reduced excessive generation of superoxide radical (O2-) and hydrogen peroxide (H2O2) (especially significant in the group with vildagliptin) and increased the activity of catalase and superoxide dismutase (especially significant in the group with v sitagliptin) but the normal values, received in group 1, were not reached. Treatment with all DPP-4 inhibitors brought the level of nitrite (NO2-) up to normal, comparable with group 1.Conclusions. DPP-4 inhibitors suppress systemic oxidative stress in rats with induced DM 2 via reduction of prooxidative molecules production and activation of antioxidant defensive system.

Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes

2010 ◽  
Vol 63 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Jeong Sook Noh ◽  
Chan Hum Park ◽  
Hyun Young Kim ◽  
Qi Zhao ◽  
Noriko Yamabe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Mouse Model ◽  
And Oxidative Stress

scholarly journals Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes

Diabetologia ◽  
2015 ◽  
Vol 58 (9) ◽  
pp. 2181-2190 ◽  
Author(s):  
Maulasri Bhatta ◽  
Jacey Hongjie Ma ◽  
Joshua J. Wang ◽  
Jonna Sakowski ◽  
Sarah X. Zhang
Keyword(s):  
Type 2 Diabetes ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Model ◽  
Progenitor Cells ◽  
Experimental Type
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