scholarly journals G Protein‐coupled receptor kinases modulate amyloid‐β generation in Alzheimer’s disease

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Nicholas Todd ◽  
Yunhong Huang ◽  
Amantha Thathiah
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
G Protein ◽  
Amyloid Β ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Association of G protein‐coupled receptor kinases with tau pathology in Alzheimer's disease

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Thais Rafael Guimaraes ◽  
Eric Swanson ◽  
Julia Kofler ◽  
Amantha Thathiah
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
G Protein ◽  
Tau Pathology ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

β-Adrenergic Receptors and G Protein-Coupled Receptor Kinase-2 in Alzheimer's Disease: A New Paradigm for Prognosis and Therapy?

2013 ◽  
Vol 34 (2) ◽  
pp. 341-347 ◽  
Author(s):  
Grazia Daniela Femminella ◽  
Giuseppe Rengo ◽  
Gennaro Pagano ◽  
Claudio de Lucia ◽  
Klara Komici ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
G Protein ◽  
Adrenergic Receptors ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
New Paradigm ◽  
Β Adrenergic Receptors ◽  
G Protein Coupled

Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease

2007 ◽  
Vol 415 (3) ◽  
pp. 279-282 ◽  
Author(s):  
Dario Leosco ◽  
Francesca Fortunato ◽  
Giuseppe Rengo ◽  
Guido Iaccarino ◽  
Emma Sanzari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Smita Eknath Desale ◽  
Hariharakrishnan Chidambaram ◽  
Subashchandrabose Chinnathambi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
G Protein ◽  
Tau Protein ◽  
Amyloid Β ◽  
Small Gtpases ◽  
Gpcr Signaling ◽  
G Protein Coupled

AbstractAlzheimer’s disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of Tau protein that forms neurofibrillary tangles (NFTs) in neuronal cells. Along with these pathological proteins, the disease shows neuroinflammation, neuronal death, impairment in the immune function of microglia and synaptic loss, which are mediated by several important signaling pathways. The PI3K/Akt-mediated survival-signaling pathway is activated by many receptors such as G-protein coupled receptors (GPCRs), triggering receptor expressed on myeloid cells 2 (TREM2), and lysophosphatidic acid (LPA) receptor. The signaling pathway not only increases the survival of neurons but also regulates inflammation, phagocytosis, cellular protection, Tau phosphorylation and Aβ secretion as well. In this review, we focused on receptors, which activate PI3K/Akt pathway and its potential to treat Alzheimer’s disease. Among several membrane receptors, GPCRs are the major drug targets for therapy, and GPCR signaling pathways are altered during Alzheimer’s disease. Several GPCRs are involved in the pathogenic progression, phosphorylation of Tau protein by activation of various cellular kinases and are involved in the amyloidogenic pathway of amyloid-β synthesis. Apart from various GPCR signaling pathways, GPCR regulating/ interacting proteins are involved in the pathogenesis of Alzheimer’s disease. These include several small GTPases, Ras homolog enriched in brain, GPCR associated sorting proteins, β-arrestins, etc., that play a critical role in disease progression and has been elaborated in this review.

scholarly journals The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 75
Author(s):  
Marta Laganà ◽  
Géraldine Schlecht-Louf ◽  
Françoise Bachelerie
Keyword(s):  
G Protein ◽  
Chemokine Receptor ◽  
Immune Cell ◽  
Neutrophil Migration ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Immune Cell Migration ◽  
And Migration ◽  
G Protein Coupled ◽  
Gpcr Desensitization

Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.

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