scholarly journals Association of G protein‐coupled receptor kinases with tau pathology in Alzheimer's disease

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Thais Rafael Guimaraes ◽  
Eric Swanson ◽  
Julia Kofler ◽  
Amantha Thathiah
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
G Protein ◽  
Tau Pathology ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

β-Adrenergic Receptors and G Protein-Coupled Receptor Kinase-2 in Alzheimer's Disease: A New Paradigm for Prognosis and Therapy?

2013 ◽  
Vol 34 (2) ◽  
pp. 341-347 ◽  
Author(s):  
Grazia Daniela Femminella ◽  
Giuseppe Rengo ◽  
Gennaro Pagano ◽  
Claudio de Lucia ◽  
Klara Komici ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
G Protein ◽  
Adrenergic Receptors ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
New Paradigm ◽  
Β Adrenergic Receptors ◽  
G Protein Coupled

Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease

2007 ◽  
Vol 415 (3) ◽  
pp. 279-282 ◽  
Author(s):  
Dario Leosco ◽  
Francesca Fortunato ◽  
Giuseppe Rengo ◽  
Guido Iaccarino ◽  
Emma Sanzari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 75
Author(s):  
Marta Laganà ◽  
Géraldine Schlecht-Louf ◽  
Françoise Bachelerie
Keyword(s):  
G Protein ◽  
Chemokine Receptor ◽  
Immune Cell ◽  
Neutrophil Migration ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Immune Cell Migration ◽  
And Migration ◽  
G Protein Coupled ◽  
Gpcr Desensitization

Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.

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