scholarly journals Self‐reported sleep duration is not associated with pet amyloid deposition in the oldest‐old: The 90+ Study

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Zarui A. Melikyan ◽  
Bryce A Mander ◽  
Dana E. Greenia ◽  
Evan M. Fletcher ◽  
Charles DeCarli ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Oldest Old ◽  
Amyloid Deposition ◽  
Pet Amyloid

scholarly journals Sleep duration and all-cause mortality in the elderly in China: a population-based cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yanfeng Ren ◽  
Maohua Miao ◽  
Wei Yuan ◽  
Jiangwei Sun
Keyword(s):  
Cohort Study ◽  
Sleep Duration ◽  
Dose Response ◽  
Cox Regression ◽  
Oldest Old ◽  
The Elderly ◽  
Response Analysis ◽  
Short Sleep Duration ◽  
All Cause Mortality

Abstract Background Although a U-shaped association between sleep duration and all-cause mortality has been found in general population, its association in the elderly adults, especially in the oldest-old, is rarely explored. Methods In present cohort study, we prospectively explore the association between sleep duration and all-cause mortality among 15,092 participants enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2005 to 2019. Sleep duration and death information was collected by using structured questionnaires. Cox regression model with sleep duration as a time-varying exposure was performed to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). The dose-response association between them was explored via a restricted cubic spline function. Results During an average follow-up of 4.51 (standard deviation, SD: 3.62) years, 10,768 participants died during the follow-up period. The mean (SD) age of the participants was 89.26 (11.56) years old. Compared to individuals with moderate sleep duration (7–8 hours), individuals with long sleep duration (> 8 hours) had a significantly higher risk of all-cause mortality (HR: 1.13, 95%CI: 1.09–1.18), but not among individuals with short sleep duration (≤ 6 hours) (HR: 1.02, 95%CI: 0.96–1.09). Similar results were observed in subgroup analyses based on age and gender. In the dose-response analysis, a J-shaped association was observed. Conclusions Sleep duration was associated with all-cause mortality in a J-shaped pattern in the elderly population in China.

P3-367: PET AMYLOID IMAGING WITH FLORBETAPIR AND COGNITION IN THE OLDEST-OLD: THE 90+ STUDY

2006 ◽  
Vol 14 (7S_Part_23) ◽  
pp. P1229-P1230
Author(s):  
Maria M. Corrada ◽  
S. Ahmad Sajjadi ◽  
Dana Greenia ◽  
Evan Fletcher ◽  
Charlie S. DeCarli ◽  
...  
Keyword(s):  
Oldest Old ◽  
Amyloid Imaging ◽  
Pet Amyloid

P2-261: Cognitive trajectories associated with beta-amyloid deposition in the nondemented oldest-old

2012 ◽  
Vol 8 (4S_Part_10) ◽  
pp. P353-P353
Author(s):  
Beth Snitz ◽  
Lisa Weissfeld ◽  
Oscar Lopez ◽  
Lewis Kuller ◽  
Judith Saxton ◽  
...  
Keyword(s):  
Oldest Old ◽  
Beta Amyloid ◽  
Amyloid Deposition

scholarly journals Sleep Duration, Vegetable Consumption and All-Cause Mortality Among Older Adults in China: A 6-Year Prospective Study

2021 ◽  
Author(s):  
Chen Bai ◽  
Muqi Guo ◽  
Yao Yao ◽  
John S. Ji ◽  
Danan Gu ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Mortality Risk ◽  
High Frequency ◽  
Lower Risk ◽  
Vegetable Intake ◽  
Vegetable Consumption ◽  
Oldest Old ◽  
Low Frequency ◽  
Demographic Model ◽  
Long Sleep

Abstract BackgroundSleep duration and vegetable consumption are associated with mortality at old age (termed as sleep-mortality linkage and vegetable-mortality linkage, respectively). Yet, little is known about the interplay of sleep duration and vegetable consumption on mortality. MethodsA dataset of nationwide longitudinal survey with 13,441 participants aged 65 years or older recruited in 2008 and followed up till 2014 was used. Sleep duration was classified into five groups (≤5, 6, 7-8, 9, and ≥10 hours/day). Vegetable consumption was classified as either high frequency (eating vegetables almost daily) or low frequency. We used parametric Weibull hazard regression models to estimate associations of sleep duration and frequency of vegetable consumption with mortality, adjusting for demographics, socioeconomic factors, family/social support, health practice, and health conditions. ResultsOver the six-year study period, when only demographics were present, participants sleeping ≤5, 6, 9, and ≥10 hours/day had hazard ratios (HR) of mortality 1.18 (p<0.001), 1.14(p<0.01), 1.06 (p>0.1), and 1.30 (p<0.001), respectively, compared to those sleeping 7-8 hours/day. The HRs were attenuated to 1.08 (p<0.05), 1.08 (p<0.05), 1.09 (p<0.1), 1.18(p<0.001), respectively, when all other covariates were additionally adjusted for. High frequency of eating vegetables was associated with 22% lower risk of mortality (HR=0.78, p<0.001) compared to low frequency in the demographic model, and with 9% lower risk (HR=0.91, p<0.05) in the full model. Subpopulation and interaction analyses show that the sleeping-mortality linkage was stronger in female, urban, oldest-old (aged ≥80), and illiterate participants compared to their respective male, rural, young-old, and literate counterparts. High frequency of vegetable intakes could offset the higher mortality risk in participants with short-sleeping duration, but low frequency of eating vegetables could exacerbate mortality risk for participants with either short or long sleep duration; and except for few cases, these findings held in subpopulations. Conclusions Too short and too long sleep durations were associated with higher mortality risk, and infrequent vegetable consumption could exacerbate the risk, although frequent vegetable intake could offset the risk for short sleep duration. The relationship between these two lifestyles and mortality was complex and varied among subpopulations.

scholarly journals Cognitive trajectories associated with  -amyloid deposition in the oldest-old without dementia

Neurology ◽  
2013 ◽  
Vol 80 (15) ◽  
pp. 1378-1384 ◽  
Author(s):  
B. E. Snitz ◽  
L. A. Weissfeld ◽  
O. L. Lopez ◽  
L. H. Kuller ◽  
J. Saxton ◽  
...  
Keyword(s):  
Oldest Old ◽  
Amyloid Deposition

scholarly journals Fruit and Vegetable Intakes and Sleep in Linkage With Cognition Among Older Adults in China

2021 ◽  
Author(s):  
Chen Bai ◽  
Yuning Xie ◽  
Danan Gu
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Oldest Old ◽  
Poor Sleep ◽  
Rural Residence ◽  
Poor Sleep Quality ◽  
Urban Rural ◽  
Good Sleep

Abstract Background: Identifying factors associated with cognitive impairment among older adults is critical. This study aims to examine associations of fruit and/or vegetable intake (FVI), sleep quality and duration, and their interactions with cognitive performance among older adults in China.Methods: We utilize nationwide datasets in 2008 and 2011 in China to examine associations between sleep quality and duration, FVI, and cognitive impairment. Interactions between sleep and FVI on cognitive performance are also examined. All analyses are further stratified by gender, age group, and urban-rural residence.Results: When all covariates are fully adjusted for in the cross-sectional analyses, frequent FVI is associated with a 29% lower risk of cognitive impairment compared with less frequent FVI, and daily sleeping durations of ≤6h and ≥10h are associated with a 13% and a 51% higher risk of cognitive impairment, respectively, as compared with the duration of 8h. Sleep quality is not significantly associated with cognitive impairment compared with fair/poor sleep quality when all covariates are adjusted, though it is associated with a 31% lower risk when only demographics are controlled for. Interaction analyses reveal that frequent FVI offsets the higher risk of cognitive impairment for poor sleep quality and excessive sleep durations. Subgroup analyses show a generally similar pattern for both sexes but a more pronounced association for young older adults than for oldest-old adults. The patterns of the interactions of FVI, sleep quality, and sleep duration with cognitive impairment differ by urban-rural residence. However, associations of good sleep quality, adequate sleep duration, and frequent FVI with the incidence of cognitive impairment over a 3-year follow-up period are mostly not significant. Conclusions: The positive association of good sleep quality, appropriate sleep duration, frequent FVI, with good cognitive is mainly cumulative or long-term. Frequent FVI could offset a higher risk of cognitive impairment for poor sleep quality and/or excessive sleep durations. The associations are similar for both sexes but are stronger in oldest-old adults and differ by urban-rural residence.

scholarly journals Association of sleep duration with risk of all-cause mortality and poor quality of dying in oldest-old people: a community-based longitudinal study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Chengbei Hou ◽  
Yinan Lin ◽  
Zachary Zimmer ◽  
Lap Ah. Tse ◽  
Xianghua Fang
Keyword(s):  
Longitudinal Study ◽  
Sleep Duration ◽  
Oldest Old ◽  
Poor Quality ◽  
Penalized Splines ◽  
Community Based ◽  
Quality Of Dying ◽  
Long Duration ◽  
All Cause Mortality

Abstract Background While sleep duration has been shown to be associated with health outcomes, few studies have been conducted among the oldest old. In addition, the impact of sleep duration on quality of dying is unknown. We aimed to evaluate how sleep duration affects all-cause mortality and quality of dying in people aged 80 + . Methods This community-based longitudinal study was performed by using data from 15,048 individuals aged ≥80 with information on sleep duration in the Chinese Longitudinal Healthy Longevity Survey. Cox and logistic regression models with penalized splines were applied to explore the shape of the association between sleep duration and all-cause mortality and poor quality of dying respectively and identify the interval of sleep duration resulting in the lowest risk of both. Results During a median follow-up of 3.1 years, 11,582 deaths including 4116 individuals who experienced poor quality of dying were recorded. Sleep duration showed a U-shaped association with all-cause mortality and sleeping about 8 h had the minimum risk of death; a J-shaped association was found between sleep duration and poor quality of dying. Compared with sleep duration of 7–9 h, the adjusted hazard ratio of total deaths was 1.08 (95% CI 1.03–1.13) for short duration (< 7 h) and 1.12 (95% CI 1.07–1.17) for long duration (> 9 h); the adjusted odds ratio of poor QOD was 1.10 (95% CI 1.01–1.21) for long duration, but this association was restricted to those with baseline unhealthy status (P-interaction = 0.04). Conclusions Sleeping a little longer may be better for individuals over 80 years old, and sleep duration of 7–9 h per day is optimal for both survival and good quality of life near death.

IC-P-063: Cognitive trajectories associated with beta-amyloid deposition in the nondemented oldest-old

2012 ◽  
Vol 8 (4S_Part_1) ◽  
pp. P37-P38
Author(s):  
Beth Snitz ◽  
Lisa Weissfeld ◽  
Oscar Lopez ◽  
Lewis Kuller ◽  
Judith Saxton ◽  
...  
Keyword(s):  
Oldest Old ◽  
Beta Amyloid ◽  
Amyloid Deposition

scholarly journals Hippocampal volume loss is associated with PET amyloid deposition in nondemented elderly individuals

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Mithra Sathishkumar ◽  
Myra S. Larson ◽  
Lisa Taylor ◽  
David Keator ◽  
Martina K. Hollearn ◽  
...  
Keyword(s):  
Hippocampal Volume ◽  
Amyloid Deposition ◽  
Volume Loss ◽  
Elderly Individuals ◽  
Pet Amyloid
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