scholarly journals Examining the causal mediating role of cardiovascular disease on the relationship between subclinical cardiovascular disease and cognitive impairment: The Cardiovascular Health Cognition Study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Ryan M Andrews ◽  
Michelle C Carlson ◽  
Vanessa Didelez
Keyword(s):  
Cardiovascular Disease ◽  
Cognitive Impairment ◽  
Cardiovascular Health ◽  
Mediating Role ◽  
Subclinical Cardiovascular Disease ◽  
Health Cognition ◽  
The Relationship

scholarly journals Cognitive health risks posed by social isolation and loneliness in older Korean Americans

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuri Jang ◽  
Eun Young Choi ◽  
Nan Sook Park ◽  
David A. Chiriboga ◽  
Lei Duan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Social Isolation ◽  
Health Risks ◽  
Korean Americans ◽  
Cognitive Health ◽  
Subjective Cognitive Impairment ◽  
Mediating Role ◽  
The Relationship ◽  
Older Korean Americans

Abstract Background This study examines associations among social isolation, loneliness, and cognitive health risks in older Korean Americans, focusing on the mediating role of loneliness in the relationship between social isolation and objective and subjective measures of cognitive impairment. Methods Data are from 2061 participants in the Study of Older Korean Americans, a multi-state survey of Korean immigrants age 60 and older (Mage = 73.2, SD = 7.93). Social isolation was indexed with the Lubben Social Network Scale− 6; loneliness, with the short-form UCLA Loneliness Scale. Objective and subjective measures of cognitive impairment included the Mini-Mental State Examination and a single-item self-rating of cognitive health. Results In the logistic regression model for objective cognitive impairment, social isolation was significantly associated, but loneliness was not. In the model for subjective cognitive impairment, both social isolation and loneliness were significant factors. However, the effect of social isolation became non-significant when loneliness was considered, suggesting a potential mediating role of loneliness. The subsequent mediation analysis confirmed that the indirect effect of social isolation on subjective cognitive impairment through loneliness was significant (B = .20, SE = .03, 95% CI = .12, .28). Conclusion Our analyses provide evidence for the proposed mediating effect of loneliness in the relationship between social isolation and subjective cognitive impairment. Intervention efforts should focus on reducing feelings of loneliness experienced by older immigrants, possibly by engaging them in socially meaningful and cognitively stimulating activities.

scholarly journals Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease

2018 ◽  
Vol 12 (7) ◽  
pp. 177-190 ◽  
Author(s):  
Virna Margarita Martín Giménez ◽  
Sandra Edith Noriega ◽  
Diego Enrique Kassuha ◽  
Lucía Beatriz Fuentes ◽  
Walter Manucha
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Endocannabinoid System ◽  
Basic Research ◽  
Renal Physiology ◽  
Detailed Knowledge ◽  
Main Role ◽  
Current Therapies ◽  
The Relationship

Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.

scholarly journals The role of cardiovascular disease in the relationship between air pollution and incident dementia: a population-based cohort study

2019 ◽  
Vol 49 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Sindana D Ilango ◽  
Hong Chen ◽  
Perry Hystad ◽  
Aaron van Donkelaar ◽  
Jeffrey C Kwong ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Air Pollution ◽  
Cardiovascular Health ◽  
Fine Particulate Matter ◽  
Population Based ◽  
Dementia Diagnosis ◽  
Incident Dementia ◽  
The Mean ◽  
The Relationship

Abstract Background Evidence suggests a link between air pollution and dementia. Cardiovascular disease (CVD) may be a potential determinant of dementia. This motivated us to quantify the contribution of CVD to the association between air pollution and dementia. Methods A cohort of Canadian-born residents of Ontario, who participated in the 1996–2003 Canadian Community Health Surveys, was followed through 2013 or until dementia diagnosis. Exposure to nitrogen dioxide (NO2) and fine particulate matter (PM2.5) was estimated with a 3-year average and 5-year lag before dementia diagnosis. Incident CVD was evaluated as a mediator. We used multi-level Cox proportional and Aalen additive hazard regression models, adjusting for individual- and neighbourhood-level risk factors to estimate associations with NO2 and PM2.5. We estimated the total, direct and indirect effects of air pollution on dementia through cardiovascular disease. Results This study included 34 391 older adults. At baseline, the mean age of this cohort was 59 years. The risk of dementia was moderately higher among those more exposed to NO2 (hazard ratio (HR) 1.10, 95% confidence interval (CI) 0.99–1.19; and 100 additional cases per 100 000 [standard error (SE) <100x10-5]) and PM2.5 [(HR 1.29, 95% CI 0.99–1.64; 200 additional cases per 100 000] [SE 100x10-5]) after adjusting for covariates; however, these estimates are imprecise. A greater proportion of the relationship between PM2.5 and dementia was mediated through CVD than NO2 for both scales. Conclusions These results suggest some of the association between air pollution and dementia is mediated through CVD, indicating that improving cardiovascular health may prevent dementia in areas with higher exposure to air pollution.

Coping Humor as a Mediator Between Emotional Intelligence and Job Satisfaction

2017 ◽  
Vol 16 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Peizhen Sun ◽  
Jennifer J. Chen ◽  
Hongyan Jiang
Keyword(s):  
Job Satisfaction ◽  
Emotional Intelligence ◽  
Future Research ◽  
Satisfaction Scale ◽  
Primary School Teachers ◽  
Mediating Role ◽  
Regulation Of Emotion ◽  
The Relationship ◽  
Overall Job Satisfaction

Abstract. This study investigated the mediating role of coping humor in the relationship between emotional intelligence (EI) and job satisfaction. Participants were 398 primary school teachers in China, who completed the Wong Law Emotional Intelligence Scale, Coping Humor Scale, and Overall Job Satisfaction Scale. Results showed that coping humor was a significant mediator between EI and job satisfaction. A further examination revealed, however, that coping humor only mediated two sub-dimensions of EI (use of emotion and regulation of emotion) and job satisfaction. Implications for future research and limitations of the study are discussed.

Sign in / Sign up

Export Citation Format

Share Document