scholarly journals Neuropsychiatric symptoms in subjective cognitive complaints (SCC) and mild cognitive impairment (MCI): Detecting changes over time with the Mild Behavioral Impairment Checklist (MBI‐C)

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Sabela C. Mallo ◽  
Arturo X. Pereiro ◽  
Maria Campos‐Magdaleno ◽  
Ana Nieto‐Vieites ◽  
Cristina Lojo‐Seoane ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychiatric Symptoms ◽  
Cognitive Complaints ◽  
Behavioral Impairment ◽  
Changes Over Time ◽  
Over Time ◽  
Subjective Cognitive Complaints

Changes in visual memory in mild cognitive impairment: a longitudinal study with CANTAB

2020 ◽  
pp. 1-11 ◽  
Author(s):  
María Campos-Magdaleno ◽  
David Leiva ◽  
Arturo X. Pereiro ◽  
Cristina Lojo-Seoane ◽  
Sabela C. Mallo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Visual Memory ◽  
Regression Models ◽  
Cognitive Status ◽  
Multinomial Regression ◽  
Cognitive Complaints ◽  
Spatial Span ◽  
Evaluation Time ◽  
Subjective Cognitive Complaints

Abstract Background Mild cognitive impairment (MCI), as a stage in the cognitive continuum between normal ageing and dementia, is mainly characterized by memory impairment. The aims of this study were to examine CANTAB measures of temporal changes of visual memory in MCI and to evaluate the usefulness of the baseline scores for predicting changes in cognitive status. Methods The study included 201 participants aged over 50 years with subjective cognitive complaints. Visual memory was assessed with four CANTAB tests [paired associates learning (PAL), delayed matching to sample (DMS), pattern recognition memory (PRM) and spatial span (SSP)] administered at baseline and on two further occasions, with a follow-up interval of 18–24 months. Participants were divided into three groups according to the change in their cognitive status: participants with subjective cognitive complaints who remained stable, MCI participants who remained stable (MCI-Stable) and MCI participants whose cognitive deterioration continued (MCI-Worsened). Linear mixed models were used to model longitudinal changes, with evaluation time as a fixed variable, and multinomial regression models were used to predict changes in cognitive status. Results Isolated significant effects were obtained for age and group with all CANTAB tests used. Interactions between evaluation time and group were identified in the PAL and DMS tests, indicating different temporal patterns depending on the changes in cognitive status. Regression models also indicated that CANTAB scores were good predictors of changes in cognitive status. Conclusions Decline in visual memory measured by PAL and DMS tests can successfully distinguish different types of MCI, and considered together PAL, DMS, PRM and SSP can predict changes in cognitive status.

Subjective Memory Complaints and Conversion to Dementia in Patients with Subjective Cognitive Decline and Patients with Mild Cognitive Impairment

2016 ◽  
Vol 27 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Johann Lehrner ◽  
Bettina Bodendorfer ◽  
Claus Lamm ◽  
Doris Moser ◽  
Peter Dal-Bianco ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Verbal Memory ◽  
Clinical Sample ◽  
Subjective Cognitive Decline ◽  
Memory Testing ◽  
Cognitive Complaints ◽  
Subjective Memory ◽  
Subjective Cognitive Complaints

Abstract. Background: Subjective cognitive complaints and their clinical significance are discussed controversially. Objectives: To determine the clinical validity of subjective cognitive complaints among subjects with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). Design: Longitudinal study with one follow up examination at a University based out-patient memory clinic. Participants: A clinical sample of patietns with SCD and MCI (n = 141), aged 50 and older, who came to the memory outpatient clinic. Results: No significant differences between converters and non converters regarding subjective cognitive complaints were detected. MCI patients had a higher risk than the patients with SCD developing AD (OR = 7.3 [CI 0.9 to 61.2]. Verbal memory testing using the Verbal Selektive Reminding Test (VSRT) showed better diagnostic validity than subjective cognitive complaints using the Forgetfulness Assessment Inventory (FAI) in predicting conversion to dementia. Conclusion: Verbal memory testing was superior in predicting conversion to dementia compared to subjective cognitive complaints.

IC-P-054: Neuropsychology and cerebral perfusion (HMPAO-SPECT) in patients with ‘subjective cognitive complaints’ and ‘Mild Cognitive Impairment’

2009 ◽  
Vol 5 (4S_Part_1) ◽  
pp. P26-P26
Author(s):  
Wolfgang Staffen ◽  
Harald Zauner ◽  
Jürgen Bergmann ◽  
Martin Kronbichler ◽  
Stefan Golaszewski ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cerebral Perfusion ◽  
Cognitive Complaints ◽  
Hmpao Spect ◽  
Subjective Cognitive Complaints

scholarly journals Subjective Cognitive Complaints in Newly-Diagnosed Parkinson’s Disease With and Without Mild Cognitive Impairment

2021 ◽  
Vol 15 ◽  
Author(s):  
Chenxi Pan ◽  
Jingru Ren ◽  
Ping Hua ◽  
Lei Yan ◽  
Miao Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Status ◽  
Newly Diagnosed ◽  
Cognitive Complaints ◽  
Subjective Cognitive Complaints

Background: Subjective cognitive complaints (SCCs) and mild cognitive impairment (MCI) are common among patients with Parkinson’s disease (PD). However, the relationship between SCCs and MCI is not well understood. Herein, we aimed to investigate whether there are any differences in the prevalence and risk factors of SCCs between early PD patients with and without MCI.Methods: Overall, 108 newly diagnosed, untreated PD patients underwent comprehensive neuropsychological assessments. PD patients with mild cognitive impairment (PD-MCI) were diagnosed according to the MCI level II criteria. Furthermore, SCCs were measured with the Cognitive Complaints Interview (CCI). Logistic regression analysis, after adjusting for confounding variable, was performed in order to investigate risk factors of SCCs in PD-MCI patients and PD patients with normal cognition (PD-NC).Results: Furthermore, 42 (42.3%) participants reported SCCs and 53 (53.5%) participants were diagnosed with PD-MCI. The prevalence of SCCs in PD-MCI and PD-NC participants was 30.3% and 12.1%, respectively. Logistic regression analyses revealed that the presence of SCCs in PD-MCI group was significantly associated with Non-Motor Symptoms Questionnaire (NMSQ) score (OR = 1.340, 95%CI = 1.115−1.610, p = 0.002), while the presence of SCCs in PD-NC group was significantly associated with time of Stroop Color-Word Test card C (OR = 1.050, 95%CI = 1.009−1.119, p = 0.016).Conclusion: SCCs are frequent among patients with early PD. The prevalence and risk factor of SCCs are distinct in PD with and without MCI. These findings suggest that SCCs in early PD with different cognitive status appear to have different pathogenicity.

scholarly journals Subjective Cognitive Complaints Contribute to Misdiagnosis of Mild Cognitive Impairment

2014 ◽  
Vol 20 (8) ◽  
pp. 836-847 ◽  
Author(s):  
Emily C. Edmonds ◽  
Lisa Delano-Wood ◽  
Douglas R. Galasko ◽  
David P. Salmon ◽  
Mark W. Bondi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cluster Analysis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Control Group ◽  
Cognitive Complaints ◽  
Informant Report ◽  
Cognitive Problems ◽  
Subjective Cognitive Complaints

AbstractSubjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory performance in MCI. We aimed to examine self-reported cognitive complaints in subgroups of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MCI cohort to determine whether they are a valuable inclusion in the diagnosis of MCI or, alternatively, if they contribute to misdiagnosis. Subgroups of MCI were derived using cluster analysis of baseline neuropsychological test data from 448 ADNI MCI participants. Cognitive complaints were assessed via the Everyday Cognition (ECog) questionnaire, and discrepancy scores were calculated between self- and informant-report. Cluster analysis revealed Amnestic and Mixed cognitive phenotypes as well as a third Cluster-Derived Normal subgroup (41.3%), whose neuropsychological and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarker profiles did not differ from a “robust” normal control group. This cognitively intact phenotype of MCI participants overestimated their cognitive problems relative to their informant, whereas Amnestic MCI participants with objective memory impairment underestimated their cognitive problems. Underestimation of cognitive problems was associated with positive CSF AD biomarkers and progression to dementia. Overall, there was no relationship between self-reported cognitive complaints and objective cognitive functioning, but significant correlations were observed with depressive symptoms. The inclusion of self-reported complaints in MCI diagnostic criteria may cloud rather than clarify diagnosis and result in high rates of misclassification of MCI. Discrepancies between self- and informant-report demonstrate that overestimation of cognitive problems is characteristic of normal aging while underestimation may reflect greater risk for cognitive decline. (JINS, 2014, 20, 1–12)

IC-P-076: WHITE MATTER HYPERINTENSITIES PREDICT MILD COGNITIVE IMPAIRMENT AND DEMENTIA IN PATIENTS WITH SUBJECTIVE COGNITIVE COMPLAINTS

2014 ◽  
Vol 10 ◽  
pp. P42-P43 ◽  
Author(s):  
Marije Renske Benedictus ◽  
Argonde Corien van Harten ◽  
Philip Scheltens ◽  
Frederik Barkhof ◽  
Niels Prins ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Cognitive Complaints ◽  
Subjective Cognitive Complaints
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