scholarly journals Determinants of subjective cognitive decline in dementia‐free older adults: A population‐based study

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Leonardo Zullo ◽  
Christopher Clark ◽  
Julius Popp ◽  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Population Based ◽  
Subjective Cognitive Decline ◽  
Population Based Study

scholarly journals Impact of the Apolipoprotein E4 allele on the Relationship Between Healthy Lifestyle and Cognitive Decline: A Population-based Study

2021 ◽  
Author(s):  
Klodian Dhana ◽  
Neelum T Aggarwal ◽  
Kumar B Rajan ◽  
Lisa L Barnes ◽  
Denis A Evans ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Genetic Predisposition ◽  
Healthy Lifestyle ◽  
Population Based ◽  
Cognitive Assessments ◽  
Population Based Study ◽  
Quality Diet ◽  
E4 Allele ◽  
The Impact

Abstract Adherence to a healthy lifestyle –characterized by abstaining from smoking, being physically and cognitively active, having a high-quality diet, and limiting alcohol use– is associated with slower cognitive decline in older adults, but whether this relationship extends to individuals with a genetic predisposition (e.g., ApoE4 carriers) remains uncertain. From the population-based study, the Chicago Health and Aging Project, we followed 3,886 individuals with regular clinical and cognitive assessments from 1993 to 2012. Of 3,886 older adults, 1,269 (32.7%) were ApoE4 carriers. Compared to non-carries, ApoE4 carriers had a faster cognitive decline by -0.027 (95%CI -0.032, -0.023) units per year. In contrast, individuals with 2-3 and 4-5 healthy lifestyle factors had a slower cognitive decline by 0.008 (95%CI 0.002, 0.014) and 0.019 (95%CI 0.011, 0.026) units per year, compared to those with 0-1 factor. In analyses stratified by ApoE4 status, adherence to a healthy lifestyle (e.g., 4-5 vs. 0-1 factors) was associated with a slower rate of cognitive decline in both ApoE4 carriers ($\beta$=0.029 units/year; 95%CI 0.013, 0.045) and non-carriers ($\beta$=0.013, 95%CI 0.005, 0.022). These results underscore the impact of a healthy lifestyle on cognition, particularly among individuals with a genetic predisposition who are more vulnerable to cognitive decline as they age.

Education Exerts Different Effects on Cognition in Individuals with Subjective Cognitive Decline and Cognitive Impairment: A Population-Based Study

2020 ◽  
pp. 1-9
Author(s):  
Guanqun Chen ◽  
Mingyan Zhao ◽  
Kun Yang ◽  
Hua Lin ◽  
Chunlei Han ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
High Education ◽  
Cognitive Decline ◽  
Educational Level ◽  
Population Based ◽  
Education Level ◽  
Subjective Cognitive Decline ◽  
Population Based Study ◽  
Low Education ◽  
Positive Effect

Background: Education plays a potential important effect on the prevalence and incidence of dementia. However, most of the evidence based on convenience sampling. Objective: To explore effects of education on cognition in individuals with subjective cognitive decline (SCD) and cognitive impairment (CI) from a population-based study. Methods: We examined the effect of education on cognition among individuals with SCD (n = 451) and CI (n = 280) from a population-based study. A series of neuropsychological tests of memory, executive, language, and general cognitive function were used to assess the participants. Results: Multiple regression analyses revealed that education has a positive effect on cognition in both SCD and CI group in the population-based research. Further stratification study showed that the beneficial effect of education remains in the SCD group regardless of the education level, especially in the SCD participants with a low education level. However, that effect of education exists in the CI group with a low education level and disappears in the high education level. Conclusion: These results from a population-based sample suggest that high educational attainment may delay cognitive decline in the individuals with SCD regardless of high or low educational level, and high education only predicts cognition in those in the low educational level in CI group.

Head injuries and cognitive decline among older adults: A population-based study

Neurology ◽  
1999 ◽  
Vol 52 (3) ◽  
pp. 557-557 ◽  
Author(s):  
H. Luukinen ◽  
P. Viramo ◽  
K. Koski ◽  
P. Laippala ◽  
S.-L. Kivela
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Head Injuries ◽  
Population Based ◽  
Population Based Study

scholarly journals Association of resting heart rate with cognitive decline and dementia in older adults: A prospective population‐based study

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Yume Imahori ◽  
Davide Liborio Vetrano ◽  
Xin Xia ◽  
Giulia Grande ◽  
Petter Ljungman ◽  
...  
Keyword(s):  
Older Adults ◽  
Heart Rate ◽  
Cognitive Decline ◽  
Population Based ◽  
Resting Heart Rate ◽  
Population Based Study

Total Cerebral Small Vessel Disease Score and Anthropometric Indices: A Population-Based Study in Older Adults of Amerindian Ancestry

2021 ◽  
pp. 1-4
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera
Keyword(s):  
Older Adults ◽  
Small Vessel Disease ◽  
Brain Magnetic Resonance Imaging ◽  
Population Based ◽  
Cerebral Small Vessel Disease ◽  
The Body ◽  
Small Vessel ◽  
Population Based Study ◽  
Vessel Disease ◽  
Ordinal Logistic Regression Model

A total of 590 older adults of Amerindian ancestry living in rural Ecuador received anthropometric measurements and a brain magnetic resonance imaging to estimate the total cerebral small vessel disease (cSVD) score. A fully adjusted ordinal logistic regression model, with categories of the total cSVD score as the dependent variable, disclosed significant associations between the waist circumference, the waist-to-hip, and the waist-to-height ratios – but not the body mass index (BMI) – and the cSVD burden. Indices of abdominal obesity may better correlate with severity of cSVD than the BMI in Amerindians. Phenotypic characteristics of this population may account for these results.

Sign in / Sign up

Export Citation Format

Share Document