Genetic variations and physical activity as determinants of limb bone morphology: An experimental approach using a mouse model

2012 ◽  
Vol 148 (1) ◽  
pp. 24-35 ◽  
Author(s):  
Ian J. Wallace ◽  
Steven M. Tommasini ◽  
Stefan Judex ◽  
Theodore Garland ◽  
Brigitte Demes
Keyword(s):  
Physical Activity ◽  
Mouse Model ◽  
Experimental Approach ◽  
Genetic Variations ◽  
Bone Morphology ◽  
Limb Bone

scholarly journals Chronic exercise does not alter limb bone morphology or microstructure in the American alligator

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Tomasz Owerkowicz ◽  
Henry P. Tsai ◽  
Linda Sanchez ◽  
Krista Felbinger ◽  
Fernando Andrade ◽  
...  
Keyword(s):  
Chronic Exercise ◽  
American Alligator ◽  
Bone Morphology ◽  
Limb Bone

Relationship between 3D lower limb bone morphology and 3D gait variables in children with uni and bilateral Cerebral Palsy

2021 ◽  
Author(s):  
BAILLY Rodolphe ◽  
LEMPEREUR Mathieu ◽  
THEPAUT Matthias ◽  
PONS Christelle ◽  
HOUX Laetitia ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Lower Limb ◽  
Bone Morphology ◽  
Limb Bone

scholarly journals Sugar Kelp (Saccharina latissima) Inhibits Hepatic Inflammation and Fibrosis with Increased Metabolic Rates in a Mouse Model of Diet-induced Nonalcoholic Steatohepatitis (OR24-08-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Mi-Bo Kim ◽  
Yoojin Lee ◽  
Minkyung Bae ◽  
Hyunju Kang ◽  
Siqi Hu ◽  
...  
Keyword(s):  
Physical Activity ◽  
Liver Fibrosis ◽  
Energy Expenditure ◽  
Mouse Model ◽  
Total Cholesterol ◽  
Nonalcoholic Steatohepatitis ◽  
Metabolic Rates ◽  
Metabolic Disturbances ◽  
Macrophage Marker ◽  
M1 Macrophage

Abstract Objectives We investigated whether consumption of sugar kelp, an edible brown seaweed, can attenuate metabolic disturbances and nonalcoholic steatohepatitis (NASH) in a mouse model of NASH with evident liver fibrosis. Methods Male C57BL/6 J mice were fed a low-fat control (LF; 6% fat by wt), a high-fat/high-sucrose/high-cholesterol control (HF; 34% fat, 34% sucrose, 2.0% cholesterol by wt), or a HF containing sugar kelp (HF-Kelp; 6.0% dried sugar kelp powder by wt) for 14 weeks. Blood chemistry as well as biochemical, molecular, and histological analyses were conducted in the liver and epididymal white adipose tissue (eWAT). Metabolic rates, energy expenditure, and physical activity of mice were determined using indirect calorimetry Results Body weight of mice fed HF-Kelp was significantly lower than that of HF group. Compared to LF, HF significantly increased serum total cholesterol and glucose, which were decreased by kelp. In the liver, HF-Kelp group showed decreases in weight, triglycerides, total cholesterol, and steatosis compared with HF-fed mice. Also, kelp decreased hepatic expression of a macrophage marker F4/80 and an M1 macrophage marker CD11c. Mice fed HF-Kelp also exhibited decreased liver fibrosis as evidenced by less expression of fibrogenic genes and collagen accumulation than those of HF group. In eWAT, HF-Kelp diet reduced weight and adipocyte size compared with HF control. While HF-Kelp diet increased mRNA abundance of peroxisome proliferator activated receptor γ, it decreased the expression of collagen type VI alpha 1 chain, F4/80, CD11c, and tumor necrosis factor α, in eWAT. Oxygen consumption, carbon dioxide production, energy expenditure, and physical activity were significantly higher in HF-Kelp group than HF. Conclusions Kelp consumption markedly prevented weight gain, fat accumulation, inflammation, and fibrosis in the liver and eWAT of mice with NASH. The health benefits of kelp were accompanied by increased metabolic rates, energy expenditure, and physical activity. Therefore, kelp may be consumed to prevent obesity-associated metabolic disturbances and NASH. Funding Sources This study was supported by USDA Hatch.

scholarly journals Objective measures of moderate to vigorous physical activity are associated with higher distal limb bone strength among elderly men

Bone ◽  
2020 ◽  
Vol 132 ◽  
pp. 115198 ◽  
Author(s):  
Lisa Langsetmo ◽  
Andrew J. Burghardt ◽  
John T. Schousboe ◽  
Peggy M. Cawthon ◽  
Jane A. Cauley ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Strength ◽  
Vigorous Physical Activity ◽  
Objective Measures ◽  
Elderly Men ◽  
Distal Limb ◽  
Limb Bone

Physical Activity and Calcium Consumption Are Important Determinants of Lower Limb Bone Mass in Older Women

2004 ◽  
Vol 19 (10) ◽  
pp. 1634-1639 ◽  
Author(s):  
Amanda Devine ◽  
Satvinder S Dhaliwal ◽  
Ian M Dick ◽  
Jens Bollerslev ◽  
Richard L Prince
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Older Women ◽  
Lower Limb ◽  
Limb Bone

scholarly journals Quantitative Limb Bone-Morphology at Man Bac

2011 ◽  
Author(s):  
Hirofumi Matsumura ◽  
Wataru Takigawa ◽  
Nguyen Kim Thuy ◽  
Nguyen Anh Tuan
Keyword(s):  
Bone Morphology ◽  
Limb Bone

scholarly journals Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model

2020 ◽  
Vol 21 (3) ◽  
pp. 843
Author(s):  
Lisa S. Robison ◽  
Nikita Francis ◽  
Dominique L. Popescu ◽  
Maria E. Anderson ◽  
Joshua Hatfield ◽  
...  
Keyword(s):  
Physical Activity ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Cerebral Amyloid Angiopathy ◽  
Environmental Enrichment ◽  
Transgenic Mouse Model ◽  
Cognitive Stimulation ◽  
Cognitive Behavioral ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid

Cerebral amyloid angiopathy (CAA) is the deposition of amyloid protein in the cerebral vasculature, a common feature in both aging and Alzheimer’s disease (AD). However, the effects of environmental factors, particularly cognitive stimulation, social stimulation, and physical activity, on CAA pathology are poorly understood. These factors, delivered in the form of the environmental enrichment (EE) paradigm in rodents, have been shown to have beneficial effects on the brain and behavior in healthy aging and AD models. However, the relative importance of these subcomponents on CAA pathology has not been investigated. Therefore, we assessed the effects of EE, social enrichment (SOC), and cognitive enrichment (COG) compared to a control group that was single housed without enrichment (SIN) from 4 to 8 months of age in wild-type mice (WT) and Tg-SwDI mice, a transgenic mouse model of CAA that exhibits cognitive/behavioral deficits. The results show that individual facets of enrichment can affect an animal model of CAA, though the SOC and combined EE conditions are generally the most effective at producing physiological, cognitive/behavioral, and neuropathological changes, adding to a growing literature supporting the benefits of lifestyle interventions.

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