Highly Efficient Construction of 2-Fluoroalkyl Quinolines through a Palladium-Catalyzed 6-endo -trig Heck Cyclization Reaction

2018 ◽  
Vol 7 (6) ◽  
pp. 1124-1131 ◽  
Author(s):  
Fangwai Han ◽  
Wenqing Yang ◽  
Aichun Zhao ◽  
Ruihong Zheng ◽  
Chenhui Ji ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Highly Efficient ◽  
Heck Cyclization ◽  
Palladium Catalyzed ◽  
Efficient Construction

An approach to unsymmetrical 3,3′-diindolylmethanes through Pd-catalyzed cascade Heck cyclization of allenamides and o-ethynylanilines

2021 ◽  
Author(s):  
Songjin Guo ◽  
Jiayi Chen ◽  
Mingjun Yi ◽  
Liuli Dong ◽  
Aijun Lin ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Heck Cyclization ◽  
Palladium Catalyzed

A highly efficient synthesis of unsymmetrical 3,3′-diindolylmethanes has been developed by palladium-catalyzed cascade Heck/cyclization reaction.

Synthesis of Novel Bis-pyrazoles via Electrophilic Cyclization

2019 ◽  
Vol 16 (6) ◽  
pp. 511-516
Author(s):  
Adnan Cetin
Keyword(s):  
13C Nmr ◽  
Cyclization Reaction ◽  
Electrophilic Cyclization ◽  
Pyrazole Derivatives ◽  
Spectral Analyses ◽  
Mass Spectral ◽  
Palladium Catalyzed ◽  
Ft Ir ◽  
Reaction Compound

Efficient steps towards the synthesis of novel (phenyl)(1'-aryl-1,5,5'-triphenyl[3,3'-bi-1Hpyrazol]- 4-yl)methanones 4a-e were developed. The procedure starts from 1-(4-benzoyl-1,5-diphenyl- 1H-3-pyrazolyl)-3-phenyl-2-propyn-1-one (2) which was synthesized by a palladium catalyzed crosscoupling reaction. Compound 2 reacted with various hydrazines to give (E)-(phenyl)[1,5-diphenyl-3- [3-phenyl-1-(2-arylhydrazono)-2-propyn-1-yl]-1H-4-pyrazolyl]methanones E-3a-e. The bis-pyrazole derivatives 4a-e were synthesized from electrophilic cyclization reaction of α,β-acetylenic hydrazones E-3a-e and copper(I) iodide. All synthesized compounds were characterized by FT-IR, 1H, 13C NMR and Mass spectral analyses.

Highly Efficient Four-Component Synthesis of 4(3H)-Quinazolinones: Palladium-Catalyzed Carbonylative Coupling Reactions

2013 ◽  
Vol 53 (5) ◽  
pp. 1420-1424 ◽  
Author(s):  
Lin He ◽  
Haoquan Li ◽  
Helfried Neumann ◽  
Matthias Beller ◽  
Xiao-Feng Wu
Keyword(s):  
Coupling Reactions ◽  
Highly Efficient ◽  
Palladium Catalyzed
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