Solvent-free, l -Leucine-Catalyzed Direct Dehydrative Esterification of Carboxylic Acids with Alcohols: Direct Synthesis of 3-Alkoxy 1(3 H )-isobenzofuranone

2017 ◽  
Vol 7 (1) ◽  
pp. 227-231 ◽  
Author(s):  
Manoranjan Kumar ◽  
Krishna Thakur ◽  
Sushila Sharma ◽  
Onkar S. Nayal ◽  
Neeraj Kumar ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Direct Synthesis ◽  
Solvent Free

scholarly journals Microwave-Assisted Catalytic Method for a Green Synthesis of Amides Directly from Amines and Carboxylic Acids

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1761 ◽  
Author(s):  
Adam P. Zarecki ◽  
Jacek L. Kolanowski ◽  
Wojciech T. Markiewicz
Keyword(s):  
Carboxylic Acids ◽  
Direct Synthesis ◽  
Solvent Free ◽  
Amide Bond ◽  
Ceric Ammonium Nitrate ◽  
Secondary Amines ◽  
Primary Amines ◽  
Catalytic Method ◽  
Effective Manner ◽  
Solvent Free Conditions

Amide bonds are among the most interesting and abundant molecules of life and products of the chemical pharmaceutical industry. In this work, we describe a method of the direct synthesis of amides from carboxylic acids and amines under solvent-free conditions using minute quantities of ceric ammonium nitrate (CAN) as a catalyst. The reactions are carried out in an open microwave reactor and allow the corresponding amides to be obtained in a fast and effective manner when compared to other procedures of the direct synthesis of amides from acids and amines reported so far in the literature. The amide product isolation procedure is simple, environmentally friendly, and is performed with no need for chromatographic purification of secondary amides due to high yields. In this report, primary amines were used in most examples. However, the developed procedure seems to be applicable for secondary amines as well. The methodology produces a limited amount of wastes, and a catalyst can be easily separated. This highly efficient, robust, rapid, solvent-free, and additional reagent-free method provides a major advancement in the development of an ideal green protocol for amide bond formation.

scholarly journals Mechanically induced solvent-free esterification method at room temperature

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5080-5085
Author(s):  
Lei Zheng ◽  
Chen Sun ◽  
Wenhao Xu ◽  
Alexandr V. Dushkin ◽  
Nikolay Polyakov ◽  
...  
Keyword(s):  
Natural Products ◽  
Carboxylic Acids ◽  
Late Stage ◽  
Reaction Mechanisms ◽  
Room Temperature ◽  
Solvent Free ◽  
Mild Conditions

We have developed I2/KH2PO2 and KI/P(OEt)3 strategy syntheses of esters from carboxylic acids and alcohols through different reaction mechanisms. The advantages of present protocol: mild conditions and late-stage diversification of natural products.

New direct synthesis of thioamides from carboxylic acids

1995 ◽  
Vol 36 (37) ◽  
pp. 6745-6746 ◽  
Author(s):  
Naleen Borthakur ◽  
Amrit Goswami
Keyword(s):  
Carboxylic Acids ◽  
Direct Synthesis

ChemInform Abstract: Direct Synthesis of Amides from Carboxylic Acids and Amines Using B(OCH2CF3)3.

ChemInform ◽  
2013 ◽  
Vol 44 (36) ◽  
pp. no-no
Author(s):  
Rachel M. Lanigan ◽  
Pavel Starkov ◽  
Tom D. Sheppard
Keyword(s):  
Carboxylic Acids ◽  
Direct Synthesis

Direct Synthesis of Tri/Difluoromethyl Ketones from Carboxylic Acids via Cross‐Coupling with Acyloxyphosphonium Ions

2021 ◽  
Author(s):  
Surya G. Prakash ◽  
Xanath Ispizua-Rodriguez ◽  
Socrates Munoz ◽  
Vinayak Krishnamurti ◽  
Thomas Mathew
Keyword(s):  
Carboxylic Acids ◽  
Direct Synthesis ◽  
Cross Coupling

Direct Oxidation of Primary Alcohols to Carboxylic Acids

Synthesis ◽  
2020 ◽  
Author(s):  
Travis J. Williams ◽  
Valeriy Cherepakhin
Keyword(s):  
Carboxylic Acids ◽  
Direct Synthesis ◽  
Primary Alcohol ◽  
Alcohol Oxidation ◽  
Atom Economy ◽  
Primary Alcohols ◽  
Direct Oxidation ◽  
Metal Compounds ◽  
New Methods ◽  
Active Research

AbstractOxidation of primary alcohols to carboxylic acids is a fundamental transformation in organic chemistry, yet despite its simplicity, extensive use, and relationship to pH, it remains a subject of active research for synthetic organic chemists. Since 2013, a great number of new methods have emerged that utilize transition-metal compounds as catalysts for acceptorless dehydrogenation of alcohols to carboxylates. The interest in this reaction is explained by its atom economy, which is in accord with the principles of sustainability and green chemistry. Therefore, the methods for the direct synthesis of carboxylic acids from alcohols is ripe for a modern survey, which we provide in this review.1 Introduction2 Thermodynamics of Primary Alcohol Oxidation3 Oxometalate Oxidation4 Transfer Dehydrogenation5 Acceptorless Dehydrogenation6 Electrochemical Methods7 Outlook

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