scholarly journals Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

2021 ◽  
Author(s):  
Bronwyn J. Overs ◽  
Gloria Roberts ◽  
Kate Ridgway ◽  
Claudio Toma ◽  
Dusan Hadzi‐Pavlovic ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young People ◽  
Suicide Attempt ◽  
Brain Structure ◽  
Risky Behavior ◽  
Familial Risk ◽  
Polygenic Risk

M49 EPIGENOME-WIDE ASSOCIATION STUDY (EWAS) OF YOUNG PEOPLE WITH FAMILIAL RISK OF BIPOLAR DISORDER

2019 ◽  
Vol 29 ◽  
pp. S192
Author(s):  
Sonia Hesam-Shariati ◽  
Bronwyn Overs ◽  
Claudio Toma ◽  
Oliver Watkeys ◽  
Melissa Green ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young People ◽  
Association Study ◽  
Familial Risk

scholarly journals Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk

2016 ◽  
Vol 46 (11) ◽  
pp. 2385-2396 ◽  
Author(s):  
G. Roberts ◽  
W. Wen ◽  
A. Frankland ◽  
T. Perich ◽  
E. Holmes-Preston ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Young People ◽  
Age Of Onset ◽  
Familial Risk ◽  
The Novel ◽  
Course Of Illness ◽  
High Genetic Risk ◽  
History Of ◽  
Recurrent Major Depressive Disorder

BackgroundWhite matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset.MethodWM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON). All subjects were aged 12 to 30 years.ResultsThis young BD group had significantly lower fractional anisotropy within the genu of the corpus callosum (CC) compared with the CON and HR groups. Moreover, the abnormality in the genu of the CC was also present in HR participants with recurrent major depressive disorder (MDD) (n = 16) compared with CON participants.ConclusionsOur findings provide important validation of interhemispheric abnormalities in BD patients. The novel finding in HR subjects with recurrent MDD – a group at particular risk of future hypo/manic episodes – suggests that this may potentially represent a trait marker for BD, though this will need to be confirmed in longitudinal follow-up studies.

scholarly journals Progressive cortical thinning might identify children at risk of developing psychotic spectrum symptoms

2021 ◽  
Keyword(s):  
At Risk ◽  
Bipolar Disorder ◽  
Brain Structure ◽  
Familial Risk ◽  
Low Risk ◽  
Children At Risk ◽  
Long Term Outcomes ◽  
Cortical Thinning ◽  
Increased Risk

Offspring of patients with schizophrenia or bipolar disorder have an increased risk of developing these conditions. However, our capacity to predict the long-term outcomes of these at-risk individuals is limited. Now, researchers have investigated whether longitudinal changes in brain structure differ in individuals at high familial risk who develop psychotic spectrum symptoms, compared to those who do not and to low-risk controls.

scholarly journals Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

2021 ◽  
Author(s):  
Bronwyn J. Overs ◽  
Gloria Roberts ◽  
Kate Ridgway ◽  
Claudio Toma ◽  
Dusan Hadzi-Pavlovic ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
High Risk ◽  
Risky Behavior ◽  
Suicide Attempts ◽  
High Risk Group ◽  
Anterior Cingulate ◽  
European Ancestry ◽  
Risk Scores ◽  
Suicidal Behaviors ◽  
Polygenic Risk

Aims: Bipolar Disorder (BD) is associated with a 20-30 fold increased suicide risk compared to the general population. First-degree relatives of BD patients show inflated rates of psychopathology including suicidal behaviors. As reliable biomarkers of suicide attempts (SA) are lacking, we examined associations between suicide-related polygenic risk scores (PRS) - a quantitative index of genomic risk - and variability in brain structures implicated in SA. Methods: Participants (n=206; aged 12-30 years) were unrelated individuals of European ancestry and comprised three groups: 41 BD cases, 96 BD relatives ('high-risk'), and 69 controls. Genotyping employed PsychArray, followed by imputation. Three PRS were computed using genome-wide association data for SA in BD (SA-in-BD), SA in Major Depressive Disorder (SA-in-MDD) [Mullins et al., 2019], and risky behavior [Karlsson Linnér et al., 2019]. Structural MRI processing employed FreeSurfer v5.3.0. General linear models were constructed using 32 regions-of-interest identified from suicide neuroimaging literature, with false-discovery-rate correction. Results: SA-in-MDD and SA-in-BD PRS negatively predicted parahippocampal thickness, with the latter association modified by group membership. SA-in-BD and Risky Behavior PRS inversely predicted rostral and caudal anterior cingulate structure, respectively, with the latter effect driven by the 'high-risk' group. SA-in-MDD and SA-in-BD PRS positively predicted cuneus structure, irrespective of group. Conclusions: This study demonstrated associations between PRS for suicide-related phenotypes and structural variability in brain regions implicated in SA. Future exploration of extended PRS, in conjunction with a range of biological, phenotypic, environmental and experiential data in high-risk populations, may inform predictive models for suicidal behaviors.

Polygenic Risk for Anxiety Influences Anxiety Comorbidity and Suicidal Behavior in Bipolar Disorder

2020 ◽  
Author(s):  
Fabiana Lopes ◽  
Kevin Zhu ◽  
Kirstin L Purves ◽  
Christopher Song ◽  
Kwangmi Ahn ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Behavior ◽  
Polygenic Risk

scholarly journals Polygenic Risk Scores for Alcohol Involvement Relate to Brain Structure in Substance‐Naïve Children: Results from the ABCD Study

2021 ◽  
Author(s):  
Alexander S. Hatoum ◽  
Emma C. Johnson ◽  
David A. A. Baranger ◽  
Sarah E. Paul ◽  
Arpana Agrawal ◽  
...  
Keyword(s):  
Brain Structure ◽  
Risk Scores ◽  
Polygenic Risk ◽  
Alcohol Involvement
Sign in / Sign up

Export Citation Format

Share Document