Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: A combined twin and family study

2008 ◽  
Vol 147B (5) ◽  
pp. 619-627 ◽  
Author(s):  
Mei‐Hua Hall ◽  
Katja Schulze ◽  
Pak Sham ◽  
Sridevi Kalidindi ◽  
Colm McDonald ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Family Study ◽  
Genetic Effects ◽  
P50 Suppression ◽  
Psychotic Bipolar Disorder ◽  
Shared Genetic

Are auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley Bipolar Twin and Family Study

2009 ◽  
Vol 39 (8) ◽  
pp. 1277-1287 ◽  
Author(s):  
M.-H. Hall ◽  
K. Schulze ◽  
F. Rijsdijk ◽  
S. Kalidindi ◽  
C. McDonald ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Structural Equation ◽  
Family Study ◽  
Genetic Model ◽  
Model Fitting ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Bipolar Patients ◽  
Psychotic Bipolar Disorder ◽  
Shared Genetic

BackgroundImpaired P300 auditory response has been reported in patients with psychotic bipolar disorder (BPD) and unaffected relatives of psychotic bipolar patients. Deficits in mismatch negativity (MMN), however, have not been observed in bipolar patients. To our knowledge, no family study of MMN in BPD has been reported. The current study combined the Maudsley twin and bipolar family samples using genetic model fitting analyses to: (1) assess the relationship between BPD and MMN, (2) substantiate the association between psychotic BPD and P300 variables, (3) verify the genetic overlap of BPD with P300 amplitude previously reported in the twin sample, and (4) examine the shared genetic influences between BPD and bilateral temporal scalp locations of P300 components.MethodA total of 301 subjects were included in this study, including 94 twin pairs, 31 bipolar families, and 39 unrelated healthy controls. Statistical analyses were based on structural equation modelling.ResultsBoth P300 and MMN are heritable, with heritability estimates of 0.58 for MMN, 0.68–0.80 for P300 amplitude, and 0.21–0.56 for P300 latency. The bipolar patients and their relatives showed normal MMN. No significant association, either genetic or environmental, was found with BPD. BPD was significantly associated with reduced P300 amplitude and prolonged latency on midline and bilateral temporal-posterior scalp areas. Shared genetic factors were the main source of these associations.ConclusionsThe results confirm that MMN is not an endophenotype for psychotic BPD whereas P300 amplitude and latency components are valid endophenotypes for psychotic BPD.

scholarly journals Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types

2017 ◽  
Vol 49 (4) ◽  
pp. 600-605 ◽  
Author(s):  
Sung Chun ◽  
Alexandra Casparino ◽  
Nikolaos A Patsopoulos ◽  
Damien C Croteau-Chonka ◽  
Benjamin A Raby ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Immune Cell ◽  
Cell Types ◽  
Genetic Effects ◽  
Statistical Evidence ◽  
Shared Genetic

scholarly journals Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders

2021 ◽  
Vol 11 (12) ◽  
pp. 1581
Author(s):  
Alexis E. Whitton ◽  
Kathryn E. Lewandowski ◽  
Mei-Hua Hall
Keyword(s):  
Bipolar Disorder ◽  
Prediction Error ◽  
Psychotic Disorders ◽  
Predictive Coding ◽  
Sensory Gating ◽  
Event Related Potential ◽  
Reward Learning ◽  
Smoking History ◽  
Impaired Performance ◽  
Psychotic Bipolar Disorder

Motivational and perceptual disturbances co-occur in psychosis and have been linked to aberrations in reward learning and sensory gating, respectively. Although traditionally studied independently, when viewed through a predictive coding framework, these processes can both be linked to dysfunction in striatal dopaminergic prediction error signaling. This study examined whether reward learning and sensory gating are correlated in individuals with psychotic disorders, and whether nicotine—a psychostimulant that amplifies phasic striatal dopamine firing—is a common modulator of these two processes. We recruited 183 patients with psychotic disorders (79 schizophrenia, 104 psychotic bipolar disorder) and 129 controls and assessed reward learning (behavioral probabilistic reward task), sensory gating (P50 event-related potential), and smoking history. Reward learning and sensory gating were correlated across the sample. Smoking influenced reward learning and sensory gating in both patient groups; however, the effects were in opposite directions. Specifically, smoking was associated with improved performance in individuals with schizophrenia but impaired performance in individuals with psychotic bipolar disorder. These findings suggest that reward learning and sensory gating are linked and modulated by smoking. However, disorder-specific associations with smoking suggest that nicotine may expose pathophysiological differences in the architecture and function of prediction error circuitry in these overlapping yet distinct psychotic disorders.

Clozapine in Treatment-Resistant Patients With Schizophrenia, Schizoaffective Disorder, or Psychotic Bipolar Disorder

2003 ◽  
Vol 64 (4) ◽  
pp. 451-458 ◽  
Author(s):  
Antonio Ciapparelli ◽  
Liliana Dell'Osso ◽  
Adolfo Bandettini di Poggio ◽  
Claudia Carmassi ◽  
Donatella Cecconi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Schizoaffective Disorder ◽  
Treatment Resistant ◽  
Psychotic Bipolar Disorder

scholarly journals F48. NEUROPSYCHOLOGICAL FUNCTIONING IN EARLY AND CHRONIC STAGES OF SCHIZOPHRENIA AND PSYCHOTIC BIPOLAR DISORDER

2019 ◽  
Vol 45 (Supplement_2) ◽  
pp. S273-S274
Author(s):  
Margo Menkes ◽  
Kristan Armstrong ◽  
Jennifer Blackford ◽  
Stephan Heckers ◽  
Neil Woodward
Keyword(s):  
Bipolar Disorder ◽  
Neuropsychological Functioning ◽  
Psychotic Bipolar Disorder

Thalamocortical Anatomical Connectivity in Schizophrenia and Psychotic Bipolar Disorder

2020 ◽  
Vol 87 (9) ◽  
pp. S447-S448
Author(s):  
Julia Sheffield ◽  
Anna Huang ◽  
Baxter Rogers ◽  
Monica Giraldo-Chica ◽  
Bennett Landman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anatomical Connectivity ◽  
Psychotic Bipolar Disorder

scholarly journals Shared Genetic Control of Brain Activity During Sleep and Insulin Secretion: A Laboratory-Based Family Study

Diabetes ◽  
2017 ◽  
Vol 67 (1) ◽  
pp. 155-164
Author(s):  
Lisa L. Morselli ◽  
Eric R. Gamazon ◽  
Esra Tasali ◽  
Nancy J. Cox ◽  
Eve Van Cauter ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Genetic Control ◽  
Family Study ◽  
Brain Activity ◽  
Shared Genetic
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