Genome-wide linkage scan, fine mapping, and haplotype analysis in a large, inbred, Arab Israeli pedigree suggest a schizophrenia susceptibility locus on chromosome 20p13

2008 ◽  
Vol 147B (2) ◽  
pp. 209-215 ◽  
Author(s):  
Omri Teltsh ◽  
Kyra Kanyas ◽  
Osnat Karni ◽  
Adi Levi ◽  
Mira Korner ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Haplotype Analysis ◽  
Susceptibility Locus ◽  
Genome Wide ◽  
Schizophrenia Susceptibility ◽  
Chromosome 20P13

scholarly journals Fine mapping of a schizophrenia susceptibility locus at chromosome 6q23: increased evidence for linkage and reduced linkage interval

2005 ◽  
Vol 13 (6) ◽  
pp. 763-771 ◽  
Author(s):  
Adi Levi ◽  
Yoav Kohn ◽  
Kyra Kanyas ◽  
Daniela Amann ◽  
Chi-Un Pae ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Susceptibility Locus ◽  
Schizophrenia Susceptibility ◽  
Linkage Interval

Fine Mapping of the Schizophrenia Susceptibility Locus on Chromosome 1q22

2002 ◽  
Vol 54 (4) ◽  
pp. 199-209 ◽  
Author(s):  
Linda M. Brzustowicz ◽  
Jared E. Hayter ◽  
Kathleen A. Hodgkinson ◽  
Eva W.C. Chow ◽  
Anne S. Bassett
Keyword(s):  
Fine Mapping ◽  
Susceptibility Locus ◽  
Schizophrenia Susceptibility

scholarly journals Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus

2018 ◽  
Vol 79 (3) ◽  
pp. 467-481 ◽  
Author(s):  
Melissa A. Buckley ◽  
Nicholas T. Woods ◽  
Jonathan P. Tyrer ◽  
Gustavo Mendoza-Fandiño ◽  
Kate Lawrenson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Functional Analysis ◽  
Fine Mapping ◽  
Cancer Susceptibility ◽  
Susceptibility Locus

scholarly journals CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies

2019 ◽  
Author(s):  
Jianhua Wang ◽  
Dandan Huang ◽  
Yao Zhou ◽  
Hongcheng Yao ◽  
Huanhuan Liu ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Genetic Variants ◽  
Association Studies ◽  
Complex Trait ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Summary Statistics ◽  
Genome Wide ◽  
Credible Sets ◽  
Causal Variants

Abstract Genome-wide association studies (GWASs) have revolutionized the field of complex trait genetics over the past decade, yet for most of the significant genotype-phenotype associations the true causal variants remain unknown. Identifying and interpreting how causal genetic variants confer disease susceptibility is still a big challenge. Herein we introduce a new database, CAUSALdb, to integrate the most comprehensive GWAS summary statistics to date and identify credible sets of potential causal variants using uniformly processed fine-mapping. The database has six major features: it (i) curates 3052 high-quality, fine-mappable GWAS summary statistics across five human super-populations and 2629 unique traits; (ii) estimates causal probabilities of all genetic variants in GWAS significant loci using three state-of-the-art fine-mapping tools; (iii) maps the reported traits to a powerful ontology MeSH, making it simple for users to browse studies on the trait tree; (iv) incorporates highly interactive Manhattan and LocusZoom-like plots to allow visualization of credible sets in a single web page more efficiently; (v) enables online comparison of causal relations on variant-, gene- and trait-levels among studies with different sample sizes or populations and (vi) offers comprehensive variant annotations by integrating massive base-wise and allele-specific functional annotations. CAUSALdb is freely available at http://mulinlab.org/causaldb.

Genome-wide search for schizophrenia susceptibility loci: The NIMH genetics initiative and millennium consortium

1998 ◽  
Vol 81 (4) ◽  
pp. 275-281 ◽  
Author(s):  
C. Robert Cloninger ◽  
Charles A. Kaufmann ◽  
Stephen V. Faraone ◽  
Dolores Malaspina ◽  
Dragan M. Svrakic ◽  
...  
Keyword(s):  
Susceptibility Loci ◽  
Genome Wide ◽  
Genome Wide Search ◽  
Schizophrenia Susceptibility
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