scholarly journals From association to cause: fine mapping of the TNRC9gene region, a novel susceptibility locus identified in the first genome-wide association study for breast cancer

2008 ◽  
Vol 10 (S2) ◽  
Author(s):  
S Ahmed ◽  
M Maranian ◽  
CS Gregory ◽  
M Udler ◽  
HI Field ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Fine Mapping ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide

scholarly journals Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62550 ◽  
Author(s):  
Yadav Sapkota ◽  
Yutaka Yasui ◽  
Raymond Lai ◽  
Malinee Sridharan ◽  
Paula J. Robson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

2009 ◽  
Vol 41 (3) ◽  
pp. 324-328 ◽  
Author(s):  
Wei Zheng ◽  
Jirong Long ◽  
Yu-Tang Gao ◽  
Chun Li ◽  
Ying Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide

scholarly journals A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

2007 ◽  
Vol 39 (7) ◽  
pp. 870-874 ◽  
Author(s):  
David J Hunter ◽  
Peter Kraft ◽  
Kevin B Jacobs ◽  
David G Cox ◽  
Meredith Yeager ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Postmenopausal Breast Cancer ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A Pilot Genome-wide Association Study of Breast Cancer Susceptibility Loci in Indonesia

2015 ◽  
Vol 16 (6) ◽  
pp. 2231-2235 ◽  
Author(s):  
Samuel J Haryono ◽  
I Gusti Bagus Datasena ◽  
Wahyu Budi Santosa ◽  
Raymond Mulyarahardja ◽  
Kartika Sari
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

scholarly journals Common Susceptibility Loci for Male Breast Cancer

2020 ◽  
Author(s):  
Sarah Maguire ◽  
Eleni Perraki ◽  
Katarzyna Tomczyk ◽  
Michael E Jones ◽  
Olivia Fletcher ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genetic Correlation ◽  
Male Breast Cancer ◽  
Genetic Basis ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Single Nucleotide ◽  
Genome Wide

Abstract Background The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC. Methods We performed genome-wide single nucleotide polymorphism genotyping of European ancestry MBC case subjects and controls in 3 stages. Associations between directly genotyped and imputed single nucleotide polymorphisms with MBC were assessed using fixed-effects meta-analysis of 1380 cases and 3620 controls. Replication genotyping of 810 cases and 1026 controls was used to validate variants with P values less than 1 × 10–06. Genetic correlation with FBC was evaluated using linkage disequilibrium score regression, by comprehensively examining the associations of published FBC risk loci with risk of MBC and by assessing associations between a FBC polygenic risk score and MBC. All statistical tests were 2-sided. Results The genome-wide association study identified 3 novel MBC susceptibility loci that attained genome-wide statistical significance (P < 5 × 10–08). Genetic correlation analysis revealed a strong shared genetic basis with estrogen receptor–positive FBC. Men in the top quintile of genetic risk had a fourfold increased risk of breast cancer relative to those in the bottom quintile (odds ratio = 3.86, 95% confidence interval = 3.07 to 4.87, P = 2.08 × 10–30). Conclusions These findings advance our understanding of the genetic basis of MBC, providing support for an overlapping genetic etiology with FBC and identifying a fourfold high-risk group of susceptible men.

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