First Risk Genes Identified for Attention Deficit Hyperactivity Disorder: An international collaboration has for the fi rst time identifi ed genetic variants that increase the risk of ADHD

2019 ◽  
Vol 179 (3) ◽  
pp. 334-335
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
International Collaboration ◽  
Attention Deficit ◽  
Genetic Variants ◽  
Risk Genes ◽  
Hyperactivity Disorder

scholarly journals Shared genetic background between children and adults with attention deficit/hyperactivity disorder

2019 ◽  
Author(s):  
Paula Rovira ◽  
Ditte Demontis ◽  
Cristina Sánchez-Mora ◽  
Tetyana Zayats ◽  
Marieke Klein ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Genetic Variants ◽  
Genetic Background ◽  
Genetic Architecture ◽  
Neurodevelopmental Disorder ◽  
Genome Wide Association Studies ◽  
Hyperactivity Disorder ◽  
Common Genetic Variants ◽  
Shared Genetic

AbstractAttention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

scholarly journals Preferential Transmission of Paternal Alleles at Risk Genes in Attention-Deficit/Hyperactivity Disorder

2005 ◽  
Vol 77 (6) ◽  
pp. 958-965 ◽  
Author(s):  
Ziarih Hawi ◽  
Ricardo Segurado ◽  
Judith Conroy ◽  
Karen Sheehan ◽  
Naomi Lowe ◽  
...  
Keyword(s):  
At Risk ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Risk Genes ◽  
Preferential Transmission ◽  
Hyperactivity Disorder

Genetic Variants and Haplotypes of Tryptophan Hydroxylase 2 and Reelin Genes May Be Linked with Attention Deficit Hyperactivity Disorder in Egyptian Children

2020 ◽  
Vol 11 (14) ◽  
pp. 2094-2103
Author(s):  
Wafaa Moustafa M. Abo El Fotoh ◽  
Noha Rabie Bayomy ◽  
Zeinab A. Kasemy ◽  
Ahmed Moustafa Barain ◽  
Basma Mofed Shalaby ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Genetic Variants ◽  
Tryptophan Hydroxylase ◽  
Tryptophan Hydroxylase 2 ◽  
Hyperactivity Disorder ◽  
Egyptian Children

scholarly journals Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior

2020 ◽  
Author(s):  
Holly K. Harris ◽  
Tojo Nakayama ◽  
Jenny Lai ◽  
Boxun Zhao ◽  
Nikoleta Argyrou ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Transcription Factors ◽  
Intellectual Disability ◽  
Attention Deficit ◽  
De Novo ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Risk Genes ◽  
Hyperactivity Disorder

Purpose: We describe a novel neurobehavioral syndrome of autism spectrum disorder, intellectual disability, and attention deficit/hyperactivity disorder associated with de novo or inherited deleterious variants in members of the RFX family of genes. RFX genes are evolutionarily conserved transcription factors that act as master regulators of central nervous system development and ciliogenesis. Methods: We assembled a cohort of 36 individuals (from 31 unrelated families) with de novo mutations in RFX3, RFX4, and RFX7. We describe their common clinical phenotypes and present bioinformatic analyses of expression patterns and downstream targets of these genes as they relate to other neurodevelopmental risk genes. Results: These individuals share neurobehavioral features including autism spectrum disorder (ASD), intellectual disability, and attention-deficit/hyperactivity disorder (ADHD); other frequent features include hypersensitivity to sensory stimuli and sleep problems. RFX3, RFX4, and RFX7 are strongly expressed in developing and adult human brain, and X-box binding motifs as well as RFX ChIP-seq peaks are enriched in the cis-regulatory regions of known ASD risk genes. Conclusion: These results establish deleterious variation in RFX3, RFX4, and RFX7 as important causes of monogenic intellectual disability, ADHD and ASD, and position these genes as potentially critical transcriptional regulators of neurobiological pathways associated with neurodevelopmental disease pathogenesis.

scholarly journals Genetic variants in SLC9A9 are associated with measures of Attention-deficit/hyperactivity disorder symptoms in families

2010 ◽  
Vol 20 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Christina A. Markunas ◽  
Kaia S. Quinn ◽  
Ann L. Collins ◽  
Melanie E. Garrett ◽  
Ave M. Lachiewicz ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Genetic Variants ◽  
Hyperactivity Disorder
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