Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study

2011 ◽  
Vol 158A (1) ◽  
pp. 109-115 ◽  
Author(s):  
A.J. Agopian ◽  
Mark A. Canfield ◽  
Richard S. Olney ◽  
Philip J. Lupo ◽  
Tunu Ramadhani ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Prevention Study ◽  
Race Ethnicity ◽  
Maternal Race

Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997–2011

2021 ◽  
pp. oemed-2021-107561
Author(s):  
Miriam R Siegel ◽  
Carissa M Rocheleau ◽  
Kendra Broadwater ◽  
Albeliz Santiago-Colón ◽  
Candice Y Johnson ◽  
...  
Keyword(s):  
Birth Defects ◽  
Cleft Lip ◽  
Population Based ◽  
Small Samples ◽  
Prevention Study ◽  
Control Data ◽  
Reproductive Effects ◽  
Race Ethnicity ◽  
Maternal Occupation ◽  
Pregnancy And Birth

ObjectiveNail technicians and hairdressers may be exposed to chemicals with potential reproductive effects. While studies have examined birth defects in children of hairdressers, those in children of nail technicians have not been evaluated. We investigated associations between selected birth defects and maternal occupation as a nail technician or hairdresser versus a non-cosmetology occupation during pregnancy.MethodsWe analysed population-based case–control data from the multisite National Birth Defects Prevention Study, 1997–2011. Cases were fetuses or infants with major structural birth defects; controls were live-born infants without major birth defects. Expert raters classified self-reported maternal jobs as nail technician, combination nail technician-hairdresser, hairdresser, other cosmetology work or non-cosmetology work. We used logistic regression to calculate adjusted ORs and 95% CIs for associations between occupation during pregnancy and birth defects, controlling for age, smoking, education and race/ethnicity.ResultsSixty-one mothers worked as nail technicians, 196 as hairdressers, 39 as combination nail technician-hairdressers and 42 810 as non-cosmetologists. The strongest associations among nail technicians included seven congenital heart defect (CHD) groups (ORs ranging from 2.7 to 3.5) and neural tube defects (OR=2.6, CI=0.8 to 8.4). Birth defects most strongly associated with hairdressing included anotia/microtia (OR=2.1, CI=0.6 to 6.9) and cleft lip with cleft palate (OR=2.0, CI=1.1 to 3.7). All oral cleft groups were associated with combination nail technician-hairdresser work (ORs ranging from 4.2 to 5.3).ConclusionsSmall samples resulted in wide CIs. Still, results suggest associations between maternal nail technician work during pregnancy and CHDs and between hairdressing work and oral clefts.

Anencephaly and spina bifida among Hispanics: Maternal, sociodemographic, and acculturation factors in the National Birth Defects Prevention Study

2009 ◽  
Vol 85 (7) ◽  
pp. 637-646 ◽  
Author(s):  
Mark A. Canfield ◽  
Tunu A. Ramadhani ◽  
Gary M. Shaw ◽  
Suzan L. Carmichael ◽  
D. Kim Waller ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Prevention Study ◽  
Acculturation Factors

Mortality among infants with birth defects: Joint effects of size at birth, gestational age, and maternal race/ethnicity

2010 ◽  
Vol 88 (9) ◽  
pp. 728-736 ◽  
Author(s):  
Wendy N. Nembhard ◽  
Jason L. Salemi ◽  
Mary K. Ethen ◽  
David E. Fixler ◽  
Mark A. Canfield
Keyword(s):  
Birth Defects ◽  
Gestational Age ◽  
Joint Effects ◽  
Race Ethnicity ◽  
Size At Birth ◽  
Maternal Race

scholarly journals Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002

2016 ◽  
Vol 106 (11) ◽  
pp. 963-971 ◽  
Author(s):  
Stacy M. Pettigrew ◽  
Erin M. Bell ◽  
Alissa R. Van Zutphen ◽  
Carissa M. Rocheleau ◽  
Gary M. Shaw ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Pesticide Exposure ◽  
Prevention Study

scholarly journals Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study

2019 ◽  
Vol 149 (2) ◽  
pp. 295-303 ◽  
Author(s):  
Thanh T Hoang ◽  
Yunping Lei ◽  
Laura E Mitchell ◽  
Shreela V Sharma ◽  
Michael D Swartz ◽  
...  
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Diet Quality ◽  
Hispanic Women ◽  
Folic Acid Supplementation ◽  
Lactase Deficiency ◽  
Prevention Study ◽  
Folic Acid Intake ◽  
Dietary Folate ◽  
Race Ethnicity

ABSTRACTBackgroundThe risk of neural tube defect (NTD)–affected pregnancies is reduced with adequate folic acid intake during early pregnancy. However, NTDs have been observed among offspring of women with adequate folic acid intake. Some of these women are possibly not absorbing enough folic acid. Because lactase deficiency can lead to poor nutrient absorption, we hypothesized that lactase-deficient women will be at increased risk of having offspring with NTDs.ObjectiveWe examined the association between maternal rs4988235 (a lactase deficiency genetic marker) and NTDs in offspring.MethodsWe conducted a case-control study using data from the National Birth Defects Prevention Study, United States, 1997–2009, restricting to non-Hispanic white (NHW) and Hispanic women. Cases were women with an offspring with an NTD (n = 378 NHW, 207 Hispanic), and controls were women with an offspring without a birth defect (n = 461 NHW, 165 Hispanic). Analyses were conducted separately by race/ethnicity, using logistic regression. Women with the CC genotype were categorized as being lactase deficient. To assess potential effect modification, analyses were stratified by lactose intake, folic acid supplementation, dietary folate, and diet quality.ResultsAmong NHW women, the odds of being lactase deficient were greater among cases compared with controls (OR: 1.37; 95% CI: 1.02, 1.82). Among Hispanic women, the odds of being lactase deficient were significantly lower among cases compared with controls (OR: 0.50, 95% CI: 0.33, 0.77). The association differed when stratified by lactose intake in NHW women (higher odds among women who consumed ≥12 g lactose/1000 kcal) and by dietary folate in Hispanic women (opposite direction of associations). The association did not differ when stratified by folic acid supplementation or diet quality.ConclusionsOur findings suggest that maternal lactase deficiency is associated with NTDs in offspring. However, we observed opposite directions of effect by race/ethnicity that could not be definitively explained.

scholarly journals Demographic Characteristics, Care, and Outcomes for Children with Oral Clefts in Three States Using Participants from the National Birth Defects Prevention Study

2009 ◽  
Vol 46 (6) ◽  
pp. 575-582 ◽  
Author(s):  
Peter Damiano ◽  
Margaret Tyler ◽  
Paul A. Romitti ◽  
Charlotte Druschel ◽  
April A. Austin ◽  
...  
Keyword(s):  
Health Care ◽  
New York ◽  
Health Status ◽  
Birth Defects ◽  
Population Based ◽  
Primary Objective ◽  
Demographic Characteristics ◽  
Prevention Study ◽  
Care Needs ◽  
Oral Clefts

Objective: The primary objective of this study was to evaluate whether there were differences in the characteristics and outcomes of care for children with oral clefts (OCs) among population-based samples in three states. Design: Data on the health status and on speech and esthetic outcomes were collected using structured telephone interviews conducted during 2005–2006 with mothers of children with OCs aged 2 to 7 in Arkansas, Iowa, and New York. Participants: Mothers of children born with nonsyndromic OCs on or after January 1, 1998, and on or before December 31, 2003, in Arkansas, Iowa, or New York. Subjects were identified through their participation in the ongoing National Birth Defects Prevention Study. Main Outcome Measures: Demographic characteristics, rating of cleft care, severity of condition, health status, esthetic outcomes, and speech problems were evaluated by state of residence. Results: Children with OCs from Arkansas were from lower income families, and their parents were less likely to be married. Children with OCs from Arkansas were more likely to have special health care needs and to require mental health care. Few differences were found across states in type of cleft, severity of cleft, or outcomes of cleft care. Conclusions: Combining results from population-based samples across multiple studies increases the variability of sample characteristics. Including multiple states can be an efficient way to learn more about the outcomes of medical care for less common conditions such as oral cleft.

Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011

2021 ◽  
Author(s):  
Elijah H. Bolin ◽  
Yevgeniya Gokun ◽  
Paul A. Romitti ◽  
Sarah C. Tinker ◽  
April D. Summers ◽  
...  
Keyword(s):  
Birth Defects ◽  
Congenital Heart Defects ◽  
Maternal Smoking ◽  
Congenital Heart ◽  
Heart Defects ◽  
Prevention Study

scholarly journals Fish consumption prior to pregnancy and pregnancy outcomes in the National Birth Defects Prevention Study, 1997–2011

2018 ◽  
Vol 22 (2) ◽  
pp. 336-343
Author(s):  
Renata H Benjamin ◽  
Laura E Mitchell ◽  
Mark A Canfield ◽  
Adrienne T Hoyt ◽  
Dejian Lai ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Birth Defects ◽  
Pregnancy Outcomes ◽  
Fish Consumption ◽  
Large Population ◽  
Population Based ◽  
Prevention Study ◽  
Preparation Methods ◽  
The Usa ◽  
Early Preterm Birth

AbstractObjectiveTo evaluate the relationships between maternal fish consumption and pregnancy outcomes in a large, population-based sample of women in the USA.DesignWe collected average fish consumption prior to pregnancy using a modified version of the semi-quantitative Willett FFQ. We estimated adjusted OR (aOR) and 95 % CI for associations between different levels of fish consumption and preterm birth (<37 weeks), early preterm birth (<32 and <35 weeks) and small-for-gestational-age infants (SGA; <10th percentile).SettingThe National Birth Defects Prevention Study (NBDPS).SubjectsControl mother–infant pairs with estimated delivery dates between 1997 and 2011 (n 10 919).ResultsNo significant associations were observed between fish consumption and preterm birth or early preterm birth (aOR = 0·7–1·0 and 0·7–0·9, respectively). The odds of having an SGA infant were elevated (aOR = 2·1; 95 % CI 1·2, 3·4) among women with daily fish consumption compared with women consuming fish less than once per month. No associations were observed between other levels of fish consumption and SGA (aOR = 0·8–1·0).ConclusionsHigh intake of fish was associated with twofold higher odds of having an SGA infant, while moderate fish consumption prior to pregnancy was not associated with preterm or SGA. Our study, like many other studies in this area, lacked information regarding preparation methods and the specific types of fish consumed. Future studies should incorporate information on nutrient and contaminant contents, preparation methods and biomarkers to assess these relationships.

scholarly journals Impact of Time to Maternal Interview on Interview Responses in the National Birth Defects Prevention Study

2013 ◽  
Vol 177 (11) ◽  
pp. 1225-1235 ◽  
Author(s):  
S. C. Tinker ◽  
C. Gibbs ◽  
M. J. Strickland ◽  
O. J. Devine ◽  
K. S. Crider ◽  
...  
Keyword(s):  
Birth Defects ◽  
Prevention Study
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