Different roles of two novel susceptibility loci for nonsyndromic orofacial clefts in a Chinese Han population.

2011 ◽  
Vol 155 (9) ◽  
pp. 2180-2185 ◽  
Author(s):  
Yongchu Pan ◽  
Weibing Zhang ◽  
Yifei Du ◽  
Na Tong ◽  
Yue Han ◽  
...  
Keyword(s):  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Orofacial Clefts ◽  
Han Population

scholarly journals Validation of Susceptibility Loci for Vitiligo Identified by GWAS in the Chinese Han Population

2020 ◽  
Vol 11 ◽  
Author(s):  
Lu Cheng ◽  
Bo Liang ◽  
Xian-Fa Tang ◽  
Xin-Ying Cai ◽  
Hui Cheng ◽  
...  
Keyword(s):  
Association Studies ◽  
Strong Association ◽  
Missense Variant ◽  
Chinese Han Population ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Han Population ◽  
Dbsnp Database

Forty-nine susceptible loci have been reported to be significantly associated with vitiligo by genome-wide association studies (GWASs) in European-derived whites. To date, some of these reported susceptibility loci have not yet been validated in the Chinese Han population. The purpose of this study was to examine whether the 16 reported susceptible loci in European-derived whites were associated with vitiligo in the Chinese Han population. Imputation was performed using our previous GWAS dataset by IMPUTE v2.2.2. The 16 imputed top single-nucleotide polymorphisms (SNPs) with suggestive signals, together with the reported SNPs, were genotyped in a total of 2581 patients and 2579 controls by the Sequenom MassARRAY system. PLINK 2.0 software was used to perform association analysis. The dbSNP database, HaploReg, and eQTL data were adopted to annotate the biological function of the SNPs. Finally, four SNPs from three loci were significantly associated with vitiligo, including rs3747517 (P = 1.29 × 10–3, OR = 0.87) in 2q24.2, rs4807000 (P = 7.78 × 10–24, OR = 0.66) and rs6510827 (P = 3.65 × 10–5, OR = 1.19) in 19p13.3, and rs4822024 (P = 6.37 × 10–10, OR = 0.67) in 22q13.2. According to the dbSNP database, rs3747517 is a missense variant of IFIH1, rs4807000 and rs6510827 are located in TICAM1, and rs4822024 is located 6 kb upstream of TEF. Further bioinformatics analysis by HaploReg and eQTL found that rs4807000, rs6510827, and rs4822024 are involved in regulating gene expression. Our study revealed the strong association of 2q24.2 (rs3747517), 19p13.3 (rs4807000, rs6510827), and 22q13.2 (rs4822024) with the risk of vitiligo in the Chinese Han population, which implicates common factors for vitiligo across different ethnicities, and helps expand the understanding of the genetic basis of this disease.

scholarly journals Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62377 ◽  
Author(s):  
Fei Zhu ◽  
Baoyu Wu ◽  
Ping Li ◽  
Jianbo Wang ◽  
Huayang Tang ◽  
...  
Keyword(s):  
Association Study ◽  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Han Population

Replication of Migraine GWAS Susceptibility Loci in Chinese Han Population

2014 ◽  
Vol 54 (4) ◽  
pp. 709-715 ◽  
Author(s):  
Xiaoping Fan ◽  
Jing Wang ◽  
Wen Fan ◽  
Lixue Chen ◽  
Bei Gui ◽  
...  
Keyword(s):  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Han Population

scholarly journals Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population

2013 ◽  
Vol 133 (2) ◽  
pp. 403-410 ◽  
Author(s):  
Xian-Fa Tang ◽  
Zheng Zhang ◽  
Da-Yan Hu ◽  
Ai-E Xu ◽  
Hai-Sheng Zhou ◽  
...  
Keyword(s):  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Association Analyses ◽  
Han Population

scholarly journals Fine mapping analysis of a region of 20q13.33 identified five independent susceptibility loci for glioma in a Chinese Han population

2012 ◽  
Vol 33 (5) ◽  
pp. 1065-1071 ◽  
Author(s):  
Xiao Song ◽  
Keke Zhou ◽  
Yingjie Zhao ◽  
Cong Huai ◽  
Yao Zhao ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Han Population ◽  
Mapping Analysis

Association of JARID2 polymorphisms with non-syndromic orofacial clefts in northern Chinese Han population

2014 ◽  
Vol 44 (5) ◽  
pp. 386-391 ◽  
Author(s):  
Yanru Hao ◽  
Na Mi ◽  
Xiaohui Jiao ◽  
Xudong Zheng ◽  
Tao Song ◽  
...  
Keyword(s):  
Chinese Han Population ◽  
Chinese Han ◽  
Orofacial Clefts ◽  
Han Population ◽  
Northern Chinese
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