Association analyses identify two susceptibility loci 5q31 and 5q22.1 for atopic dermatitis in Chinese Han population

2017 ◽  
Keyword(s):  
Atopic Dermatitis ◽  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Association Analyses ◽  
Han Population

scholarly journals Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population

2013 ◽  
Vol 133 (2) ◽  
pp. 403-410 ◽  
Author(s):  
Xian-Fa Tang ◽  
Zheng Zhang ◽  
Da-Yan Hu ◽  
Ai-E Xu ◽  
Hai-Sheng Zhou ◽  
...  
Keyword(s):  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Association Analyses ◽  
Han Population

scholarly journals Validation of Susceptibility Loci for Vitiligo Identified by GWAS in the Chinese Han Population

2020 ◽  
Vol 11 ◽  
Author(s):  
Lu Cheng ◽  
Bo Liang ◽  
Xian-Fa Tang ◽  
Xin-Ying Cai ◽  
Hui Cheng ◽  
...  
Keyword(s):  
Association Studies ◽  
Strong Association ◽  
Missense Variant ◽  
Chinese Han Population ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Han Population ◽  
Dbsnp Database

Forty-nine susceptible loci have been reported to be significantly associated with vitiligo by genome-wide association studies (GWASs) in European-derived whites. To date, some of these reported susceptibility loci have not yet been validated in the Chinese Han population. The purpose of this study was to examine whether the 16 reported susceptible loci in European-derived whites were associated with vitiligo in the Chinese Han population. Imputation was performed using our previous GWAS dataset by IMPUTE v2.2.2. The 16 imputed top single-nucleotide polymorphisms (SNPs) with suggestive signals, together with the reported SNPs, were genotyped in a total of 2581 patients and 2579 controls by the Sequenom MassARRAY system. PLINK 2.0 software was used to perform association analysis. The dbSNP database, HaploReg, and eQTL data were adopted to annotate the biological function of the SNPs. Finally, four SNPs from three loci were significantly associated with vitiligo, including rs3747517 (P = 1.29 × 10–3, OR = 0.87) in 2q24.2, rs4807000 (P = 7.78 × 10–24, OR = 0.66) and rs6510827 (P = 3.65 × 10–5, OR = 1.19) in 19p13.3, and rs4822024 (P = 6.37 × 10–10, OR = 0.67) in 22q13.2. According to the dbSNP database, rs3747517 is a missense variant of IFIH1, rs4807000 and rs6510827 are located in TICAM1, and rs4822024 is located 6 kb upstream of TEF. Further bioinformatics analysis by HaploReg and eQTL found that rs4807000, rs6510827, and rs4822024 are involved in regulating gene expression. Our study revealed the strong association of 2q24.2 (rs3747517), 19p13.3 (rs4807000, rs6510827), and 22q13.2 (rs4822024) with the risk of vitiligo in the Chinese Han population, which implicates common factors for vitiligo across different ethnicities, and helps expand the understanding of the genetic basis of this disease.

scholarly journals Filaggrin Gene Mutation c.3321delA is Associated with Dry Phenotypes of Atopic Dermatitis in the Chinese Han Population

2016 ◽  
Vol 129 (12) ◽  
pp. 1498-1500 ◽  
Author(s):  
Wei-Long Zhong ◽  
Xia Wu ◽  
Bo Yu ◽  
Jie Zhang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gene Mutation ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62377 ◽  
Author(s):  
Fei Zhu ◽  
Baoyu Wu ◽  
Ping Li ◽  
Jianbo Wang ◽  
Huayang Tang ◽  
...  
Keyword(s):  
Association Study ◽  
Chinese Han Population ◽  
Susceptibility Loci ◽  
Chinese Han ◽  
Han Population

Four genetic variants interact to confer susceptibility to atopic dermatitis in Chinese Han population

2015 ◽  
Vol 290 (4) ◽  
pp. 1493-1498 ◽  
Author(s):  
Changbing Shen ◽  
Longdan Liu ◽  
Zengqiong Jiang ◽  
Xiaodong Zheng ◽  
Li Meng ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Genetic Variants ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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