Reproductive suppression and longevity in human birth cohorts

2019 ◽  
Vol 32 (3) ◽  
Author(s):  
Katherine B. Saxton ◽  
Alison Gemmill ◽  
Joan A. Casey ◽  
Holly Elser ◽  
Deborah Karasek ◽  
...  
Keyword(s):  
Birth Cohorts ◽  
Reproductive Suppression ◽  
Human Birth

scholarly journals A test of oscillation in the human secondary sex ratio

2020 ◽  
Vol 2020 (1) ◽  
pp. 225-233 ◽  
Author(s):  
Ralph Catalano ◽  
Joan A Casey ◽  
Tim A Bruckner
Keyword(s):  
Time Series ◽  
Sex Ratio ◽  
Female Offspring ◽  
Vital Statistics ◽  
Birth Cohorts ◽  
Reproductive Suppression ◽  
Female Ratio ◽  
Secondary Sex Ratio ◽  
Male To Female ◽  
Human Birth

Abstract Background and objectives The sex ratio of human birth cohorts predicts the health and longevity of their members. Most literature invokes natural selection in support of the argument that heritable tendencies to produce male or female offspring induce oscillation in the sex ratio and its sequelae. Tests of the argument remain exceedingly rare because they require vital statistics describing many generations of a population both unaffected by migration and exposed to an exogenous stressor virulent enough to change the sex ratio at birth. We contribute to the literature by using time-series modeling to detect oscillation in the best data currently available for such a test. Methodology We apply rigorous time-series methods to data describing Sweden from 1751 through 1830, a period when the population not only aged in place without migration, but also exhibited the effects of an Icelandic volcanic eruption including a historically low secondary sex ratio. That very low sex ratio should have induced oscillation if heritable mechanisms appear in humans. Results We detected oscillation in the ratio but not that predicted by heritable tendencies to produce males or females. We found peak-to-trough oscillation at 14 rather than the approximately 32 years expected from the heritable tendencies argument. Conclusions and implications Our findings suggest that mechanisms other than perturbation of heritable tendencies to produce males or females induce oscillation in the human secondary sex ratio. These other mechanisms may include reproductive suppression and selection in utero. LAY SUMMARY The male to female ratio in human birth cohorts predicts longevity but its variation over time remains unexplained. We test the long-held theory that the ratio oscillates due to heritable tendencies to produce males or females. We find oscillation, but it appears due to social processes rather than heritable mechanisms.

Gender-specific selectionin uteroamong contemporary human birth cohorts

2009 ◽  
Vol 23 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Ralph Catalano ◽  
Jennifer Ahern ◽  
Tim Bruckner ◽  
Elizabeth Anderson ◽  
Katherine Saxton
Keyword(s):  
Birth Cohorts ◽  
Gender Specific ◽  
Human Birth

Pulmonary Function Tests in European Birth Cohorts

2013 ◽  
Vol 9 (1) ◽  
pp. 3-10
Author(s):  
Linus Grabenhenrich ◽  
Cynthia Hohmann ◽  
Remy Slama ◽  
Joachim Heinrich ◽  
Magnus Wickman ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Birth Cohorts ◽  
Function Tests

scholarly journals A gold mine, but still no Klondike: Nordic register data in health inequalities research

2019 ◽  
Vol 47 (6) ◽  
pp. 618-630 ◽  
Author(s):  
Kjetil A. Van Der Wel ◽  
Olof Östergren ◽  
Olle Lundberg ◽  
Kaarina Korhonen ◽  
Pekka Martikainen ◽  
...  
Keyword(s):  
National Level ◽  
Data Access ◽  
Register Data ◽  
Future Research ◽  
Gold Mine ◽  
Birth Cohorts ◽  
Policy And Practice ◽  
Research Papers ◽  
Processing Times ◽  
Acquisition Processes

Aims: Future research on health inequality relies on data that cover life-course exposure, different birth cohorts and variation in policy contexts. Nordic register data have long been celebrated as a ‘gold mine’ for research, and fulfil many of these criteria. However, access to and use of such data are hampered by a number of hurdles and bottlenecks. We present and discuss the experiences of an ongoing Nordic consortium from the process of acquiring register data on socio-economic conditions and health in Denmark, Finland, Norway and Sweden. Methods: We compare experiences of data-acquisition processes from a researcher’s perspective in the four countries and discuss the comparability of register data and the modes of collaboration available to researchers, given the prevailing ethical and legal restrictions. Results: The application processes we experienced were time-consuming, and decision structures were often fragmented. We found substantial variation between the countries in terms of processing times, costs and the administrative burden of the researcher. Concerned agencies differed in policy and practice which influenced both how and when data were delivered. These discrepancies present a challenge to comparative research. Conclusions: We conclude that there are few signs of harmonisation, as called for by previous policy documents and research papers. Ethical vetting needs to be centralised both within and between countries in order to improve data access. Institutional factors that seem to facilitate access to register data at the national level include single storage environments for health and social data, simplified ethical vetting and user guidance.

scholarly journals Incidence of Benign Meningiomas in the United States: Current and Future Trends

2021 ◽  
Author(s):  
Sonia Bhala ◽  
Douglas R Stewart ◽  
Victoria Kennerley ◽  
Valentina I Petkov ◽  
Philip S Rosenberg ◽  
...  
Keyword(s):  
United States ◽  
Age Groups ◽  
Cancer Registries ◽  
Health Impact ◽  
The United States ◽  
Birth Cohorts ◽  
Benign Meningioma ◽  
Case Count ◽  
Future Burden ◽  
Rate Ratios

Abstract Background Benign meningiomas are the most frequently reported central nervous system tumors in the United States (US), with increasing incidence in past decades. However, the future trajectory of this neoplasm remains unclear. Methods We analyzed benign meningioma incidence of cases identified by any means (eg, radiographically with or without microscopic confirmation) in US Surveillance Epidemiology and End Results (SEER) cancer registries among 35–84-year-olds during 2004–2017 by sex and race/ethnicity using age-period-cohort (APC) models. We employed APC forecasting models to glean insights regarding the etiology, distribution, and anticipated future (2018–2027) public health impact of this neoplasm. Results In all groups, meningioma incidence overall increased through 2010, then stabilized. Temporal declines were statistically significant overall and in most groups. JoinPoint analysis of cohort rate-ratios identified substantial acceleration in White men born after 1963 (from 1.1% to 3.2% per birth year); cohort rate-ratios were stable or increasing in all groups and all birth cohorts. We forecast that meningioma incidence through 2027 will remain stable or decrease among 55–84-year-olds but remain similar to current levels among 35–54-year-olds. Total meningioma burden in 2027 is expected to be approximately 30,470 cases, similar to the expected case count of 27,830 in 2018. Conclusions Between 2004–2017, overall incidence of benign meningioma increased and then stabilized or declined. For 2018–2027, our forecast is incidence will remain generally stable in younger age groups but decrease in older age groups. Nonetheless, the total future burden will remain similar to current levels because the population is aging.

Association between maternal prepregnancy body mass index with offspring cardiometabolic risk factors: analysis of three Brazilian birth cohorts

2021 ◽  
pp. 1-7
Author(s):  
Mariane da Silva Dias ◽  
Alicia Matijasevich ◽  
Ana Maria B. Menezes ◽  
Fernando C. Barros ◽  
Fernando C. Wehrmeister ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Diastolic Blood Pressure ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
Birth Cohorts ◽  
Prepregnancy Bmi ◽  
Prepregnancy Body Mass Index

Abstract Evidence suggests that maternal prepregnancy body mass index (BMI) is associated with offspring cardiometabolic risk factors. This study was aimed at assessing the association of maternal prepregnancy BMI with offspring cardiometabolic risk factors in adolescence and adulthood. We also evaluated whether offspring BMI was a mediator in this association. The study included mother–offspring pairs from three Pelotas birth cohorts. Offspring cardiometabolic risk factors were collected in the last follow-up of each cohort [mean age (in years) 30.2, 22.6, 10.9]. Blood pressure was measured using an automatic device, cholesterol by using an enzymatic colorimetric method, and glucose from fingertip blood, using a portable glucose meter. In a pooled analysis of the cohorts, multiple linear regression was used to control for confounding. Mediation analysis was conducted using G-computation formula. In the adjusted model, mean systolic blood pressure of offspring from overweight and obese mothers was on average 1.25 (95% CI: 0.45; 2.05) and 2.13 (95% CI: 0.66; 3.59) mmHg higher than that of offspring from normal-weight mothers; for diastolic blood pressure, the means were 0.80 (95% CI: 0.26; 1.34) and 2.60 (95% CI: 1.62; 3.59) mmHg higher, respectively. Non-HDL cholesterol was positively associated with maternal BMI, whereas blood glucose was not associated. Mediation analyses showed that offspring BMI explained completely the association of maternal prepregnancy BMI with offspring systolic and diastolic blood pressure, and non-HDL cholesterol. Our findings suggest that maternal prepregnancy BMI is positively associated with offspring blood pressure, and blood lipids, and this association is explained by offspring BMI.

scholarly journals Use of Protection for Unwanted Pregnancy and Sexually Transmitted Infections in Six Birth Cohorts in Norway 2020: A Descriptive Study

2021 ◽  
Author(s):  
Bente Træen ◽  
Nantje Fischer
Keyword(s):  
General Population ◽  
Sexually Transmitted Infections ◽  
Emergency Contraception ◽  
Unwanted Pregnancy ◽  
Hormonal Contraception ◽  
Descriptive Study ◽  
Panel Survey ◽  
Birth Cohorts ◽  
Significant Drop ◽  
Sexually Transmitted

AbstractThis study describes the use of contraception and protection for sexually transmitted infections (STIs) in six different birth cohorts of the general population in Norway. The results are based on a 2020 national web panel survey among 18–89 year-olds in Norway (n = 4160). For respondents born within 1931–1950 versus those born within 1990–2002, there was a significant increase in the use of protection against unwanted pregnancy and STIs during sexual intercourse, and a significant drop in the proportion of those who did not use any protection at all. More women today (than in previous decades) are using hormonal contraception. The main reason for not using condoms during intercourse was both parties felt safe that they were healthy, especially those born within 1990–2002. To prevent unwanted pregnancy and STIs, it is beneficial to continue to increase the availability of free or subsidized hormonal contraception, including emergency contraception, and free condoms in public arenas that people frequent and where they meet their partners.

Early growth according to protein content of infant formula: Results from the EDEN and ELFE birth cohorts

2021 ◽  
Author(s):  
Aurore Camier ◽  
Camille Davisse‐Paturet ◽  
Pauline Scherdel ◽  
Sandrine Lioret ◽  
Barbara Heude ◽  
...  
Keyword(s):  
Protein Content ◽  
Infant Formula ◽  
Early Growth ◽  
Birth Cohorts
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