Changes in adiposity and body mass index from late childhood to adult life in the Trois-Rivières Study

2001 ◽  
Vol 13 (3) ◽  
pp. 349-355 ◽  
Author(s):  
François Trudeau ◽  
Roy J. Shephard ◽  
François Arsenault ◽  
Louis Laurencelle
Thorax ◽  
2019 ◽  
Vol 74 (10) ◽  
pp. 958-964 ◽  
Author(s):  
Magnus Pär Ekström ◽  
Anders Blomberg ◽  
Göran Bergström ◽  
John Brandberg ◽  
Kenneth Caidahl ◽  
...  

IntroductionBreathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear.MethodsThis population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score ≥1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.ResultsWe included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m2; and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness.ConclusionBreathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes.


2021 ◽  
Author(s):  
Simran Arjani ◽  
Pedro F. Saint-Maurice ◽  
Sachelly Julian-Serrano ◽  
Rachael Stolzenberg-Solomon

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ida K. Karlsson ◽  
Kelli Lehto ◽  
Margaret Gatz ◽  
Chandra A. Reynolds ◽  
Anna K. Dahl Aslan

2000 ◽  
Vol 278 (4) ◽  
pp. E700-E706 ◽  
Author(s):  
Daniel E. Flanagan ◽  
Vivienne M. Moore ◽  
Ian F. Godsland ◽  
Richard A. Cockington ◽  
Jeffrey S. Robinson ◽  
...  

Although there is now substantial evidence linking low birthweight with impaired glucose tolerance and type 2 diabetes in adult life, the extent to which reduced fetal growth is associated with impaired insulin sensitivity, defective insulin secretion, or a combination of both factors is not clear. We have therefore examined the relationships between birth size and both insulin sensitivity and insulin secretion as assessed by an intravenous glucose tolerance test with minimal model analysis in 163 men and women, aged 20 yr, born at term in Adelaide, South Australia. Birth size did not correlate with body mass index or fat distribution in men or women. Men who were lighter or shorter as babies were less insulin sensitive ( P = 0.03 and P = 0.01, respectively), independently of their body mass index or body fat distribution. They also had higher insulin secretion ( P = 0.007 and P = 0.006) and increased glucose effectiveness ( P = 0.003 and P = 0.003). Overall glucose tolerance, however, did not correlate with birth size, suggesting that the reduced insulin sensitivity was being compensated for by an increase in insulin secretion and insulin-independent glucose disposal. There were no relationships between birth size and insulin sensitivity or insulin secretion in women. These results show that small size at birth is associated with increased insulin resistance and hyperinsulinemia in young adult life but that these relationships are restricted to the male gender in this age group.


PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87896 ◽  
Author(s):  
Karthik Darmasseelane ◽  
Matthew J. Hyde ◽  
Shalini Santhakumaran ◽  
Chris Gale ◽  
Neena Modi

2013 ◽  
Vol 19 (6) ◽  
pp. 754-764 ◽  
Author(s):  
Jill M Holm-Denoma ◽  
April Smith ◽  
Peter M Lewinsohn ◽  
Jeremy W Pettit

Hippocampus ◽  
2020 ◽  
Author(s):  
Kirsten M. Lynch ◽  
Kathleen A. Page ◽  
Yonggang Shi ◽  
Anny H. Xiang ◽  
Arthur W. Toga ◽  
...  

Author(s):  
Gabriela P. Peralta ◽  
Elaine Fuertes ◽  
Anne-Elie Carsin ◽  
Nicole Probst-Hensch ◽  
Alessandro Marcon ◽  
...  

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