A normal mean cell volume does not exclude a diagnosis of megaloblastic anemia

2021 ◽  
Author(s):  
Kamala Gurung ◽  
Barbara J. Bain
Keyword(s):  
Cell Volume ◽  
Megaloblastic Anemia ◽  
Mean Cell Volume ◽  
Normal Mean

MEGALOBLASTIC ANÆMIA WITH NORMAL MEAN CELL VOLUME

The Lancet ◽  
1979 ◽  
Vol 313 (8112) ◽  
pp. 389-390 ◽  
Author(s):  
D.G. Oscier ◽  
T.J. Hamblin
Keyword(s):  
Cell Volume ◽  
Megaloblastic Anaemia ◽  
Mean Cell Volume ◽  
Normal Mean

scholarly journals Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia [see comments]

Blood ◽  
1990 ◽  
Vol 76 (5) ◽  
pp. 1004-1007 ◽  
Author(s):  
ML Gulley ◽  
SA Bentley ◽  
DW Ross
Keyword(s):  
Cell Volume ◽  
Blood Count ◽  
Complete Blood Count ◽  
Megaloblastic Anemia ◽  
Myeloperoxidase Activity ◽  
Mean Cell Volume

Abstract We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean cell volume (MCV) and five without macrocytosis. Regardless of the MCV, our megaloblastic patients had hypersegmented neutrophils and elevated MPXI levels without visible alteration of granule content. MPXI measurement may be particularly useful in identifying cases of “masked megaloblastic anemia” where the MCV is below 100 fL. The advantage of the MPXI over other methods of uncovering masked megaloblastic anemia is its simplicity when performed as part of a routine complete blood count on an automated hematology instrument.

MEGALOBLASTIC ANÆMIA WITH NORMAL MEAN CELL VOLUME

The Lancet ◽  
1979 ◽  
Vol 313 (8117) ◽  
pp. 675 ◽  
Author(s):  
D.W. Dawson ◽  
J. Chang
Keyword(s):  
Cell Volume ◽  
Megaloblastic Anaemia ◽  
Mean Cell Volume ◽  
Normal Mean

MEGALOBLASTIC ANÆMIA WITH NORMAL MEAN CELL VOLUME

The Lancet ◽  
1979 ◽  
Vol 313 (8116) ◽  
pp. 606-607 ◽  
Author(s):  
A.G. Prentice ◽  
I.L. Evans
Keyword(s):  
Cell Volume ◽  
Megaloblastic Anaemia ◽  
Mean Cell Volume ◽  
Normal Mean

Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia [see comments]

Blood ◽  
1990 ◽  
Vol 76 (5) ◽  
pp. 1004-1007
Author(s):  
ML Gulley ◽  
SA Bentley ◽  
DW Ross
Keyword(s):  
Cell Volume ◽  
Blood Count ◽  
Complete Blood Count ◽  
Megaloblastic Anemia ◽  
Myeloperoxidase Activity ◽  
Mean Cell Volume

We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean cell volume (MCV) and five without macrocytosis. Regardless of the MCV, our megaloblastic patients had hypersegmented neutrophils and elevated MPXI levels without visible alteration of granule content. MPXI measurement may be particularly useful in identifying cases of “masked megaloblastic anemia” where the MCV is below 100 fL. The advantage of the MPXI over other methods of uncovering masked megaloblastic anemia is its simplicity when performed as part of a routine complete blood count on an automated hematology instrument.

MEAN CELL VOLUME AND GAMMA-GLUTAMYL-TRANSPEPTIDASE AS MARKERS OF DRINKING IN WORKING MEN

The Lancet ◽  
1981 ◽  
Vol 317 (8232) ◽  
pp. 1249-1251 ◽  
Author(s):  
Jonathan Chick ◽  
Norman Kreitman ◽  
Martin Plant
Keyword(s):  
Cell Volume ◽  
Gamma Glutamyl Transpeptidase ◽  
Mean Cell Volume ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Alteration of the erythrocyte ultrastructure and blood viscosity by morphine

1978 ◽  
Vol 56 (2) ◽  
pp. 245-251 ◽  
Author(s):  
E. B. Vadas ◽  
E. A. Hosein
Keyword(s):  
Cell Volume ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Plasma Viscosity ◽  
Cell Geometry ◽  
Flow Properties ◽  
Mean Cell Volume ◽  
Morphine Administration ◽  
The Mean ◽  
Volume Cell

The effects of acute morphine administration on intact erythrocytes and on their flow properties were studied by measuring the mean cell volume, cell geometry, and whole blood and plasma viscosities. Morphine caused a small (2–7%) increase in mean cell volume. Changes in cell geometry were found to be time dependent and most pronounced in concave portions of the red cells. Whole blood viscosity was found to decrease upon morphine treatment; this may be due in part to a concurrent decrease in plasma viscosity.

scholarly journals Alpha thalassemia and the hematology of homozygous sickle cell disease in childhood

Blood ◽  
1986 ◽  
Vol 67 (2) ◽  
pp. 411-414 ◽  
Author(s):  
MC Stevens ◽  
GH Maude ◽  
M Beckford ◽  
Y Grandison ◽  
K Mason ◽  
...  
Keyword(s):  
Cell Volume ◽  
Sickle Cell ◽  
Globin Gene ◽  
Fetal Hemoglobin ◽  
Mean Cell Volume ◽  
Gene Group ◽  
Cell Counts ◽  
Total Hemoglobin ◽  
Alpha Thalassemia ◽  
Gene Status

alpha Thalassemia modifies the hematologic expression of homozygous sickle cell (SS) disease, resulting in increased total hemoglobin and HbA2 and decreased HbF, mean cell volume, reticulocytes, irreversibly sickled cells, and bilirubin levels. The age at which these changes develop in children with SS disease is unknown. Ascertainment of globin gene status in a large representative sample of children with SS disease has afforded an opportunity to study the hematologic indices in nine children homozygous for alpha thalassemia 2 (two-gene group), 90 children heterozygous for alpha thalassemia 2 (three-gene group), and 167 children with a normal alpha globin gene complement (four-gene group). The two-gene group had significantly lower mean cell volumes from birth, higher red cell counts from one month, lower reticulocytes from three months, and higher HbA2 levels from one year, as compared with the four-gene group. Children with three genes had intermediate indices but resembled more closely the four-gene group. Differences in total hemoglobin or in fetal hemoglobin between the groups were not apparent by eight years of age. The most characteristic differences of the two-gene group were the raised proportional HbA2 level and low mean cell volume, the latter having some predictive value for alpha thalassemia status at birth.

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