scholarly journals A case series describing causes of death in pregnant women with sickle cell disease in a low-resource setting

2018 ◽  
Vol 93 (7) ◽  
pp. E167-E170 ◽  
Author(s):  
Eugenia Vicky Asare ◽  
Edeghonghon Olayemi ◽  
Theodore Boafor ◽  
Yvonne Dei-Adomakoh ◽  
Enoch Mensah ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Causes Of Death ◽  
Case Series ◽  
Cell Disease ◽  
Low Resource ◽  
Resource Setting ◽  
Low Resource Setting

scholarly journals Implementation of multidisciplinary care reduces maternal mortality in women with sickle cell disease living in low-resource setting

2017 ◽  
Vol 92 (9) ◽  
pp. 872-878 ◽  
Author(s):  
Eugenia Vicky Asare ◽  
Edeghonghon Olayemi ◽  
Theodore Boafor ◽  
Yvonne Dei-Adomakoh ◽  
Enoch Mensah ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Maternal Mortality ◽  
Sickle Cell ◽  
Multidisciplinary Care ◽  
Cell Disease ◽  
Low Resource ◽  
Resource Setting ◽  
Low Resource Setting

scholarly journals Efficacy and Safety of Manual Partial Red Cell Exchange in the Management of Severe Complications of Sickle Cell Disease in a Developing Country

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
B. F. Faye ◽  
D. Sow ◽  
M. Seck ◽  
N. Dieng ◽  
S. A. Toure ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Blood Count ◽  
Acute Chest Syndrome ◽  
Red Cell ◽  
Efficacy And Safety ◽  
Cell Disease ◽  
Resource Setting ◽  
Low Resource Setting ◽  
The Mean

Introduction. The realization of red cell exchange (RCE) in Africa faces the lack of blood, transfusion safety, and equipment. We evaluated its efficacy and safety in severe complications of sickle cell disease. Patients and Method. Manual partial RCE was performed among sickle cell patients who had severe complications. Efficacy was evaluated by clinical evolution, blood count, and electrophoresis of hemoglobin. Safety was evaluated on adverse effects, infections, and alloimmunization. Results. We performed 166 partial RCE among 44 patients including 41 homozygous (SS) and 2 heterozygous composites SC and 1 S/β0-thalassemia. The mean age was 27.9 years. The sex ratio was 1.58. The regression of symptoms was complete in 100% of persistent vasoocclusive crisis and acute chest syndrome, 56.7% of intermittent priapism, and 30% of stroke. It was partial in 100% of leg ulcers and null in acute priapism. The mean variations of hemoglobin and hematocrit rate after one procedure were, respectively, +1.4 g/dL and +4.4%. That of hemoglobin S after 2 consecutive RCE was −60%. Neither alloimmunization nor viral seroconversion was observed. Conclusion. This work shows the feasibility of manual partial RCE in a low-resource setting and its efficacy and safety during complications of SCD outside of acute priapism.

scholarly journals Outcomes of COVID-19 in Pregnant Women with Sickle Cell Disease in India: A Case Series

2021 ◽  
Author(s):  
Rakesh Waghmare ◽  
Itta Krishna Chaaithanya ◽  
Sarika Zala ◽  
Jitendra Deshmukh ◽  
Prashant Uikey ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Case Series ◽  
Cell Disease

O945 Maternal morbidity in pregnant women with sickle cell disease

2009 ◽  
Vol 107 ◽  
pp. S362-S362
Author(s):  
K. Tosta ◽  
R. Nomura ◽  
A. Igai ◽  
G. Fonseca ◽  
S. Gualandro ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Maternal Morbidity ◽  
Cell Disease

Evaluation of pregnant women with scarred uterus in a low resource setting

2007 ◽  
Vol 33 (5) ◽  
pp. 651-654 ◽  
Author(s):  
Anjoo Agarwal ◽  
Poonam Chowdhary ◽  
Vinita Das ◽  
Aarti Srivastava ◽  
Amita Pandey ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Low Resource ◽  
Resource Setting ◽  
Low Resource Setting ◽  
Scarred Uterus

scholarly journals Microfluidics in Sickle Cell Disease Research: State of the Art and a Perspective Beyond the Flow Problem

2021 ◽  
Vol 7 ◽  
Author(s):  
Anupam Aich ◽  
Yann Lamarre ◽  
Daniel Pereira Sacomani ◽  
Simone Kashima ◽  
Dimas Tadeu Covas ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Flow Problem ◽  
Red Cells ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Intercellular Interaction ◽  
Blood Disorder ◽  
Resource Setting ◽  
Wide Range

Sickle cell disease (SCD) is the monogenic hemoglobinopathy where mutated sickle hemoglobin molecules polymerize to form long fibers under deoxygenated state and deform red blood cells (RBCs) into predominantly sickle form. Sickled RBCs stick to the vascular bed and obstruct blood flow in extreme conditions, leading to acute painful vaso-occlusion crises (VOCs) – the leading cause of mortality in SCD. Being a blood disorder of deformed RBCs, SCD manifests a wide-range of organ-specific clinical complications of life (in addition to chronic pain) such as stroke, acute chest syndrome (ACS) and pulmonary hypertension in the lung, nephropathy, auto-splenectomy, and splenomegaly, hand-foot syndrome, leg ulcer, stress erythropoiesis, osteonecrosis and osteoporosis. The physiological inception for VOC was initially thought to be only a fluid flow problem in microvascular space originated from increased viscosity due to aggregates of sickled RBCs; however, over the last three decades, multiple molecular and cellular mechanisms have been identified that aid the VOC in vivo. Activation of adhesion molecules in vascular endothelium and on RBC membranes, activated neutrophils and platelets, increased viscosity of the blood, and fluid physics driving sickled and deformed RBCs to the vascular wall (known as margination of flow) – all of these come together to orchestrate VOC. Microfluidic technology in sickle research was primarily adopted to benefit from mimicking the microvascular network to observe RBC flow under low oxygen conditions as models of VOC. However, over the last decade, microfluidics has evolved as a valuable tool to extract biophysical characteristics of sickle red cells, measure deformability of sickle red cells under simulated oxygen gradient and shear, drug testing, in vitro models of intercellular interaction on endothelialized or adhesion molecule-functionalized channels to understand adhesion in sickle microenvironment, characterizing biomechanics and microrheology, biomarker identification, and last but not least, for developing point-of-care diagnostic technologies for low resource setting. Several of these platforms have already demonstrated true potential to be translated from bench to bedside. Emerging microfluidics-based technologies for studying heterotypic cell–cell interactions, organ-on-chip application and drug dosage screening can be employed to sickle research field due to their wide-ranging advantages.

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