scholarly journals Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma

2011 ◽  
Vol 86 (12) ◽  
pp. 998-1000 ◽  
Author(s):  
Carrie A. Thompson ◽  
Matthew J. Maurer ◽  
James R. Cerhan ◽  
Jerry A. Katzmann ◽  
Stephen M. Ansell ◽  
...  
Keyword(s):  
Overall Survival ◽  
Hodgkin Lymphoma ◽  
Elevated Serum ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

scholarly journals Elevated Serum Free Light Chains Predict Cardiovascular Events in Type 2 Diabetes: Table 1

Diabetes Care ◽  
2014 ◽  
Vol 37 (7) ◽  
pp. 2028-2030 ◽  
Author(s):  
Srikanth Bellary ◽  
Jeffrey M. Faint ◽  
Lakhvir K. Assi ◽  
Colin A. Hutchison ◽  
Stephen J. Harding ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Events ◽  
Elevated Serum ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

1139 ABNORMALLY ELEVATED SERUM FREE LIGHT CHAINS IN PATIENTS WITH LIVER DISEASE

2010 ◽  
Vol 52 ◽  
pp. S440-S441 ◽  
Author(s):  
L.K. Assi ◽  
R.G. Hughes ◽  
B. Gunson ◽  
G.M. Webb ◽  
M.T. Drayson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Elevated Serum ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

4.1 Elevated Serum Free Light Chains Independently Identify a Poor Risk Group of Stage A CLL Patients

2011 ◽  
Vol 11 ◽  
pp. S218 ◽  
Author(s):  
Guy Pratt ◽  
Philip J. Young ◽  
Chris Pepper ◽  
Chris Fegan ◽  
Anne Gardiner ◽  
...  
Keyword(s):  
Risk Group ◽  
Elevated Serum ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Poor Risk ◽  
Serum Free Light Chains

scholarly journals Serum Free Light Chain Concentration (>1000mg/dl) at Diagnosis and at Relapse Predicts for Very Poor Prognosis in Multiple Myeloma

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5698-5698
Author(s):  
Abhishek Chilkulwar ◽  
Prerna Mewawalla ◽  
Anna Miller ◽  
Gina Berteotti ◽  
Entezam Sahovic ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Overall Survival ◽  
Disease Progression ◽  
Light Chain ◽  
Free Light Chain ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chain ◽  
Serum Free Light Chains

Abstract Background: There have been significant improvements in the outcomes for patients with multiple myeloma over the past 10 years. The course of the disease remains highly variable. While some patients experience 10-15 year survivals, others succumb to highly refractory disease within a few months. Many studies have focused on the description of prognostic factors capable of predicting this heterogeneity in survival. Baseline Serum free light chain concentration is a major prognostic indicator for plasma cell neoplasms and normalization of free light chain ratio with treatment has been reported as an indicator for favorable prognosis. High Baseline free light chain concentration at presentation indicates aggressive disease. Furthermore High serum free light chain ratio correlates with elevated serum creatinine, elevated LDH and extensive marrow infiltration. Objectives: To determine if serum free light chain concentration > 1000mg/dl at the time of diagnosis and at disease progression was an independent prognostic marker for multiple myeloma. Methods: The results of all the serum free light chain analyses of patients evaluated at western Pennsylvania hospital between 2007 -2015 were reviewed and patients with serum free light chain concentration >1000mg/dl at the time of initial diagnosis and disease progression were identified Retrospective chart review was done to study the survival in these patients. Results: Total of 15 patients in whom serum free light chain concentration was greater than 1000 mg/dl at diagnosis were identified. Median age at diagnosis was 60.81 years (45.2-77.3). The median survival in this population is 1.85 years (range 0.06-8.85 years), with 5 deaths. Of these 15, 9 patients received an autologous PBSCT as a part of their initial therapy. Six of them are alive with a median overall survival of 2.44 years and mean survival of 3.89 years (range 0.87-8.89). In the remaining 6 patients that did not undergo an auto PBSCT 3 of them are alive with median overall survival of 1.21 years and a mean survival 1.20 years (range 06-2.76 years). There is an overall trend toward very poor prognosis in this specific group of patients irrespective of the age, sex, stage at time of diagnosis, the immunoglobulin subtype and the free light chain subtype (kappa vs lambda). We also conducted a retrospective review of patients in whom serum free light chains concentration was greater than 1000mg/dl at disease progression. Twenty patients were identified all of whom are deceased with a median overall survival from the time of progression with serum free light chains greater than 1000 mg /dl was dismal at 0.27 years and mean survival was 0.53 years (range 0.04-2.52 years) Conclusion: Patients with multiple myeloma who presented with a serum free light chain concentration greater than 1000 mg/dl at diagnosis have very poor prognosis. These specific subgroups of patients should be identified and treated aggressively at the time of diagnosis to prevent complications from multiple myeloma and improve their overall survival. In our small cohort of patients those who underwent auto PBSCT as a part of their initial therapy tend to have better outcomes in terms of overall survival compared to patients who received therapy without auto PBSCT consolidation. Patients with serum free light chains greater than 1000 mg/dl at disease progression will need to be treated aggressively with perhaps a salvage auto PBSCT to improve their overall outcome. A larger study to evaluate elevated serum free light chains (greater than 1000 mg/dl) as a prognostic indicator at diagnosis and progression should be done to further validate these findings Table 1 Table 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Elevated serum free light chains do not predict outcome of elderly patients with aggressive CD20+B-cell lymphomas

2014 ◽  
Vol 167 (3) ◽  
pp. 430-434
Author(s):  
Marina Achenbach ◽  
Joerg Thomas Bittenbring ◽  
Marita Ziepert ◽  
Evi Regitz ◽  
German Ott ◽  
...  
Keyword(s):  
Elderly Patients ◽  
B Cell ◽  
Elevated Serum ◽  
Light Chains ◽  
B Cell Lymphomas ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains
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