Biomimetic biphasic 3-D nanocomposite scaffold for osteochondral regeneration

AIChE Journal ◽  
2013 ◽  
Vol 60 (2) ◽  
pp. 432-442 ◽  
Author(s):  
Nathan J. Castro ◽  
Christopher M. O'Brien ◽  
Lijie Grace Zhang
Keyword(s):  
Nanocomposite Scaffold ◽  
Osteochondral Regeneration

scholarly journals Attachment, Proliferation, and Chondroinduction of Mesenchymal Stem Cells on Porous Chitosan-Calcium Phosphate Scaffolds

2013 ◽  
Vol 7 (1) ◽  
pp. 275-281 ◽  
Author(s):  
Steven Elder ◽  
Anuhya Gottipati ◽  
Hilary Zelenka ◽  
Joel Bumgardner
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Calcium Phosphate ◽  
Treatment Options ◽  
Preliminary Investigation ◽  
Osteochondral Lesions ◽  
Porous Chitosan ◽  
Tissue Engineering Approach ◽  
Osteochondral Regeneration ◽  
Further Development

Symptomatic osteochondral lesions occur frequently, but relatively few treatment options are currently available. The purpose of this study was to conduct a preliminary investigation into a new tissue engineering approach to osteochondral regeneration. The concept is a biphasic construct consisting of a porous, osteoconductive chitosan-calcium phosphate scaffold supporting a layer of neocartilage formed by marrow-derived mesenchymal stem cells. Two experiments were conducted to assess the feasibility of this approach. The first experiment characterized the attachment efficiency and proliferation of primary human marrow-derived mesenchymal stem cells seeded relatively sparely onto the scaffold’s surface. The second experiment compared two different methods of creating a biphasic construct using a much higher density of primary porcine marrow stromal cells. About 40% of the sparsely seeded human cells attached and proliferated rapidly. Constructs formed by one of the two experimental techniques exhibited a layer of cartilaginous tissue which only partially covered the scaffold’s surface due to inadequate adhesion between the cells and the scaffold. This study demonstrates some potential for the approach to yield an implantable biphasic construct, but further development is required to improve cell-scaffold adhesion.

In vivo investigation of PCL/PHBV/Hydroxyapatite Nanocomposite Scaffold in Regeneration of Critical-sized Bone Defects

2021 ◽  
Author(s):  
Amir Nahanmoghadam ◽  
Maryam Asemani ◽  
Vahabodin Goodarzi ◽  
Somayeh Ebrahimi-Barough
Keyword(s):  
Bone Defects ◽  
Nanocomposite Scaffold

An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration

Biomaterials ◽  
2019 ◽  
Vol 192 ◽  
pp. 149-158 ◽  
Author(s):  
Yanlun Zhu ◽  
Lingzhi Kong ◽  
Fatemeh Farhadi ◽  
Wei Xia ◽  
Jiang Chang ◽  
...  
Keyword(s):  
Osteochondral Regeneration

A new injectable biphasic hydrogel based on partially hydrolyzed polyacrylamide and nanohydroxyapatite as scaffold for osteochondral regeneration

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 9089-9096 ◽  
Author(s):  
Newsha Koushki ◽  
Ali Asghar Katbab ◽  
Hossein Tavassoli ◽  
Azadeh Jahanbakhsh ◽  
Mohammad Majidi ◽  
...  
Keyword(s):  
Partially Hydrolyzed Polyacrylamide ◽  
Osteochondral Repair ◽  
Nanocrystalline Hydroxyapatite ◽  
Hydrolyzed Polyacrylamide ◽  
Osteochondral Regeneration ◽  
Novel Scaffold ◽  
Chromium Acetate

Fabrication of an injectable biphasic hydrogel based on partially hydrolyzed polyacrylamide (HPAM), nanocrystalline hydroxyapatite (nHAp), and chromium acetate (Cr(iii)) as a novel scaffold for osteochondral repair has been attempted.

scholarly journals Current strategies for osteochondral regeneration: from stem cells to pre-clinical approaches

2011 ◽  
Vol 22 (5) ◽  
pp. 726-733 ◽  
Author(s):  
Márcia T Rodrigues ◽  
Manuela E Gomes ◽  
Rui L Reis
Keyword(s):  
Stem Cells ◽  
Osteochondral Regeneration
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