scholarly journals A General Method to Develop Highly Environmentally Sensitive Fluorescent Probes and AIEgens

2021 ◽  
pp. 2104609
Author(s):  
Rong Miao ◽  
Jing Li ◽  
Chao Wang ◽  
Xuefeng Jiang ◽  
Ying Gao ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Environmentally Sensitive ◽  
General Method

Discovery of Nonpeptide, Environmentally Sensitive Fluorescent Probes for Imaging p53-MDM2 Interactions in Living Cell Lines and Tissue Slice

2020 ◽  
Vol 92 (3) ◽  
pp. 2642-2648 ◽  
Author(s):  
Gaopan Dong ◽  
Shipeng He ◽  
Xiaojun Qin ◽  
Tingting Liu ◽  
Yan Jiang ◽  
...  
Keyword(s):  
Cell Lines ◽  
Fluorescent Probes ◽  
Living Cell ◽  
Tissue Slice ◽  
Environmentally Sensitive

scholarly journals Selected peptide-based fluorescent probes for biological applications

2020 ◽  
Vol 16 ◽  
pp. 2971-2982
Author(s):  
Debabrata Maity
Keyword(s):  
Fluorescent Probes ◽  
Direct Detection ◽  
Aqueous Media ◽  
Live Cells ◽  
Biological Applications ◽  
Site Specific ◽  
Specific Manner ◽  
Environmentally Sensitive ◽  
Living Organisms ◽  
A Site

To understand the molecular interactions, present in living organisms and their environments, chemists are trying to create novel chemical tools. In this regard, peptide-based fluorescence techniques have attracted immense interest. Synthetic peptide-based fluorescent probes are advantageous over protein-based sensors, since they are synthetically accessible, more stable, and can be easily modified in a site-specific manner for selective biological applications. Peptide receptors labeled with environmentally sensitive/FRET fluorophores have allowed direct detection/monitoring of biomolecules in aqueous media and in live cells. In this review, key peptide-based approaches for different biological applications are presented.

Synthesis and photophysical evaluation of new fluorescent 7-arylethynyl-7-deazaadenosine analogs

2018 ◽  
Vol 96 (12) ◽  
pp. 1093-1100 ◽  
Author(s):  
Augusto Matarazzo ◽  
Justin Brow ◽  
Robert H.E. Hudson
Keyword(s):  
Fluorescent Probes ◽  
Emission Intensity ◽  
Spectral Properties ◽  
Fluorescence Emission ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Quantum Yields ◽  
Cross Coupling Reaction ◽  
Fluorescence Emission Intensity ◽  
Environmentally Sensitive

Three new fluorescent 7-deaza-2′-deoxyadenosine analogs were synthesized via the Sonogashira cross-coupling reaction of 7-iodo-7-deaza-2′-deoxyadenosine with 1-ethynylpyrene, 2-ethynyl-6-methoxynaphthalene, and 9-ethynylphenanthrene. The spectral properties of these analogs were evaluated in dioxane, EtOH, and H2O to determine their potential for use as environmentally sensitive fluorescent probes. All three analogs displayed large solvatofluorochromicity in H2O, relative to their emission wavelengths in dioxane or EtOH. Moreover, all three analogs exhibited microenvironmental sensitivity of their fluorescence emission intensity, being moderate to high quantum yields in dioxane and EtOH and significantly lower in H2O. Various attempts to perform domino cross-coupling and annuation reactions on 7-deaza-7-alkynyladenine derivatives to form a new fused tricyclic adenine analog were unsuccessful.

A General Method for Spectrometer Design in the Scoff Approximation

1976 ◽  
Vol 34 ◽  
pp. 538-539
Author(s):  
J. R. Fields
Keyword(s):  
Electron Microscope ◽  
Transmission Electron Microscope ◽  
Energy Analysis ◽  
Incident Beam ◽  
Scanning Transmission Electron Microscope ◽  
Chemical Identification ◽  
Scanning Transmission Electron ◽  
Transmission Electron ◽  
Scanning Transmission ◽  
General Method

The energy analysis of electrons scattered by a specimen in a scanning transmission electron microscope can improve contrast as well as aid in chemical identification. In so far as energy analysis is useful, one would like to be able to design a spectrometer which is tailored to his particular needs. In our own case, we require a spectrometer which will accept a parallel incident beam and which will focus the electrons in both the median and perpendicular planes. In addition, since we intend to follow the spectrometer by a detector array rather than a single energy selecting slit, we need as great a dispersion as possible. Therefore, we would like to follow our spectrometer by a magnifying lens. Consequently, the line along which electrons of varying energy are dispersed must be normal to the direction of the central ray at the spectrometer exit.

Phase behavior of cationic and anionic surfactants at low concentrations

1992 ◽  
Vol 50 (1) ◽  
pp. 694-695
Author(s):  
E. Naranjo
Keyword(s):  
Phase Behavior ◽  
Structural Characterization ◽  
Dynamic Systems ◽  
Anionic Surfactants ◽  
Intermolecular Forces ◽  
Stable Form ◽  
Surfactant Mixtures ◽  
Low Concentrations ◽  
Cationic And Anionic Surfactants ◽  
General Method

Equilibrium vesicles, those which are the stable form of aggregation and form spontaneously on mixing surfactant with water, have never been demonstrated in single component bilayers and only rarely in lipid or surfactant mixtures. Designing a simple and general method for producing spontaneous and stable vesicles depends on a better understanding of the thermodynamics of aggregation, the interplay of intermolecular forces in surfactants, and an efficient way of doing structural characterization in dynamic systems.

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