scholarly journals Probing Multicellular Tissue Fusion of Cocultured Spheroids—A 3D‐Bioassembly Model

2021 ◽  
pp. 2103320
Author(s):  
Gabriella C. J. Lindberg ◽  
Xiaolin Cui ◽  
Mitchell Durham ◽  
Laura Veenendaal ◽  
Benjamin S. Schon ◽  
...  
Keyword(s):  
Tissue Fusion

Tissue fusion and enhanced genotypic diversity support the survival of Pocillopora acuta coral recruits under thermal stress

Coral Reefs ◽  
2021 ◽  
Vol 40 (2) ◽  
pp. 447-458
Author(s):  
Ariana S. Huffmyer ◽  
Crawford Drury ◽  
Eva Majerová ◽  
Judith D. Lemus ◽  
Ruth D. Gates
Keyword(s):  
Thermal Stress ◽  
Genotypic Diversity ◽  
Tissue Fusion

Bond Strength of Thermally Fused Vascular Tissue Varies With Apposition Force

2015 ◽  
Vol 137 (12) ◽  
Author(s):  
Nicholas S. Anderson ◽  
Eric A. Kramer ◽  
James D. Cezo ◽  
Virginia L. Ferguson ◽  
Mark E. Rentschler
Keyword(s):  
Bond Strength ◽  
Blood Vessels ◽  
Thermal Energy ◽  
Molecular Mechanisms ◽  
Vascular Tissue ◽  
Tissue Temperature ◽  
Tissue Fusion ◽  
Tunica Media ◽  
Adhesive Mechanics ◽  
Bond Strengths

Surgical tissue fusion devices ligate blood vessels using thermal energy and coaptation pressure, while the molecular mechanisms underlying tissue fusion remain unclear. This study characterizes the influence of apposition force during fusion on bond strength, tissue temperature, and seal morphology. Porcine splenic arteries were thermally fused at varying apposition forces (10–500 N). Maximum bond strengths were attained at 40 N of apposition force. Bonds formed between 10 and 50 N contained laminated medial layers; those formed above 50 N contained only adventitia. These findings suggest that commercial fusion devices operate at greater than optimal apposition forces, and that constituents of the tunica media may alter the adhesive mechanics of the fusion mechanism.

Temperature Measurement Methods During Direct Heat Arterial Tissue Fusion

2013 ◽  
Vol 60 (9) ◽  
pp. 2552-2558 ◽  
Author(s):  
James D. Cezo ◽  
Eric Kramer ◽  
Kenneth D. Taylor ◽  
Virginia Ferguson ◽  
Mark E. Rentschler
Keyword(s):  
Temperature Measurement ◽  
Measurement Methods ◽  
Tissue Fusion ◽  
Arterial Tissue

Energy-Based Tissue Fusion for Sutureless Closure: Applications, Mechanisms, and Potential for Functional Recovery

2018 ◽  
Vol 20 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Eric A. Kramer ◽  
Mark E. Rentschler
Keyword(s):  
Surgical Techniques ◽  
Connective Tissues ◽  
Tissue Fusion ◽  
Minimally Invasive Surgical ◽  
Dipole Interactions ◽  
Vessel Sealing ◽  
Vascular Ligation ◽  
Cross Links ◽  
Molecular Bonding

As minimally invasive surgical techniques progress, the demand for efficient, reliable methods for vascular ligation and tissue closure becomes pronounced. The surgical advantages of energy-based vessel sealing exceed those of traditional, compression-based ligatures in procedures sensitive to duration, foreign bodies, and recovery time alike. Although the use of energy-based devices to seal or transect vasculature and connective tissue bundles is widespread, the breadth of heating strategies and energy dosimetry used across devices underscores an uncertainty as to the molecular nature of the sealing mechanism and induced tissue effect. Furthermore, energy-based techniques exhibit promise for the closure and functional repair of soft and connective tissues in the nervous, enteral, and dermal tissue domains. A constitutive theory of molecular bonding forces that arise in response to supraphysiological temperatures is required in order to optimize and progress the use of energy-based tissue fusion. While rapid tissue bonding has been suggested to arise from dehydration, dipole interactions, molecular cross-links, or the coagulation of cellular proteins, long-term functional tissue repair across fusion boundaries requires that the reaction to thermal damage be tailored to catalyze the onset of biological healing and remodeling. In this review, we compile and contrast findings from published thermal fusion research in an effort to encourage a molecular approach to characterization of the prevalent and promising energy-based tissue bond.

Measurement of Bond Strength of Direct Heat Tissue Fusion in Arteries

2012 ◽  
Author(s):  
James D. Cezo ◽  
Virginia L. Ferguson ◽  
Kenneth D. Taylor ◽  
Mark E. Rentschler
Keyword(s):  
Bond Strength ◽  
Peel Strength ◽  
Burst Pressure ◽  
Tissue Composition ◽  
Tissue Fusion ◽  
Vessel Lumen ◽  
Surgical Tool ◽  
Arterial Tissue ◽  
Future Evaluation ◽  
Tearing Strength

Tissue fusion is a method of joining tissue using heat and pressure. Several surgical tool companies have developed devices which perform tissue fusion on blood vessels in order to perform ligation of the vessel [1]. The success or failure of these devices is contingent upon the strength of the bond it creates between opposing sides of the blood vessel lumen, yet little characterization has been done to measure the strength of this interface. Previous studies have examined the strength of tissue fusion using clinically relevant metrics such as burst pressure or tearing strength, but none have explored metrics more appropriate for determining the mechanics of the actual bond, such as peel strength or shear strength [2–3]. These clinical metrics are susceptible to large variations due to tissue composition and geometry. The goal of this study is to measure the bond’s modulus and strength using standard engineering methods. The motivation of the present work is to develop a method for quantitatively measuring the strength of the bond made during tissue fusion. This method can then be applied to quantify the strength of the fusion interface between arterial tissue using other devices and aid in future evaluation and development of tissue fusion devices to maximize the bond strength.

Progress Towards Seamless Tissue Fusion for Wound Closure

2005 ◽  
Vol 38 (2) ◽  
pp. 295-305 ◽  
Author(s):  
Stephen T. Flock ◽  
Kevin S. Marchitto
Keyword(s):  
Wound Closure ◽  
Tissue Fusion
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