scholarly journals Low‐Intensity Focused Ultrasound‐Responsive Ferrite‐Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics

2021 ◽  
pp. 2100850
Author(s):  
Jianting Yao ◽  
Zhuowen Yang ◽  
Liandi Huang ◽  
Chao Yang ◽  
Jianxin Wang ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Encapsulated Nanoparticles

Ferrite-encapsulated nanoparticles with stable photothermal performance for multimodal imaging-guided atherosclerotic plaque neovascularization therapy

2021 ◽  
Author(s):  
Zhuowen Yang ◽  
Jianting Yao ◽  
Jianxin Wang ◽  
Cong Zhang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Multimodal Imaging ◽  
Plaque Rupture ◽  
Pathological Angiogenesis ◽  
Atherosclerotic Plaque Rupture ◽  
Encapsulated Nanoparticles

Pathological angiogenesis is a critical contributor to atherosclerotic plaque rupture. However, there are few effective theranostic strategies to stabilize plaques by suppressing neovascularization. A polymeric nanosystem using 3 nm manganese...

Effects of External Low Intensity Focused Ultrasound on Inflammatory Markers in Neuropathic Pain

2021 ◽  
pp. 135977
Author(s):  
Abigail Hellman ◽  
Alicia Clum ◽  
Teresa Maietta ◽  
Adithya Srikanthan ◽  
Vraj Patel ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Inflammatory Markers ◽  
Focused Ultrasound ◽  
Low Intensity

scholarly journals Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

2018 ◽  
Vol 128 (3) ◽  
pp. 875-884 ◽  
Author(s):  
Robert F. Dallapiazza ◽  
Kelsie F. Timbie ◽  
Stephen Holmberg ◽  
Jeremy Gatesman ◽  
M. Beatriz Lopes ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Thalamic Nucleus ◽  
Acoustic Energy ◽  
Similar Degree ◽  
Thalamic Nuclei ◽  
Low Intensity ◽  
Tissue Heating ◽  
The Central Nervous System ◽  
Selective Mapping ◽  
Noninvasive Neuromodulation

OBJECTIVEUltrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal.METHODSTen Yorkshire swine (Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage.RESULTSLIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage.CONCLUSIONSThese results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.

Quantification of Displacement for Tactile Sensation in a Contact-type Low Intensity Focused Ultrasound Haptic Device

2020 ◽  
Vol 18 (1) ◽  
pp. 1-8
Author(s):  
Jeongbong Choi ◽  
Soonhyun Yook ◽  
In Young Kim ◽  
Mok Kun Jeong ◽  
Dong Pyo Jang
Keyword(s):  
Focused Ultrasound ◽  
Haptic Device ◽  
Tactile Sensation ◽  
Contact Type ◽  
Low Intensity

Modulating the Inflammatory Reflex in Rats Using Low-Intensity Focused Ultrasound Stimulation of the Vagus Nerve

2019 ◽  
Vol 45 (2) ◽  
pp. 481-489 ◽  
Author(s):  
Kelsey M. Wasilczuk ◽  
Kelsey C. Bayer ◽  
Jesse P. Somann ◽  
Gabriel O. Albors ◽  
Jennifer Sturgis ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Stimulation Of

In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound

2014 ◽  
Vol 10 (5) ◽  
pp. e901-e904 ◽  
Author(s):  
Silvia Rizzitelli ◽  
Pierangela Giustetto ◽  
Cinzia Boffa ◽  
Daniela Delli Castelli ◽  
Juan Carlos Cutrin ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Local Application ◽  
Low Intensity
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