scholarly journals DNA Assembly‐Based Stimuli‐Responsive Systems

2021 ◽  
pp. 2100328
Author(s):  
Shasha Lu ◽  
Jianlei Shen ◽  
Chunhai Fan ◽  
Qian Li ◽  
Xiurong Yang
Keyword(s):  
Dna Assembly ◽  
Stimuli Responsive ◽  
Responsive Systems

scholarly journals Dynamic DNA Origami Devices: from Strand-Displacement Reactions to External-Stimuli Responsive Systems

2018 ◽  
Vol 19 (7) ◽  
pp. 2114 ◽  
Author(s):  
Heini Ijäs ◽  
Sami Nummelin ◽  
Boxuan Shen ◽  
Mauri Kostiainen ◽  
Veikko Linko
Keyword(s):  
Dna Sequences ◽  
Rapid Evolution ◽  
Dna Nanotechnology ◽  
Dna Origami ◽  
Dna Assembly ◽  
Stimuli Responsive ◽  
Nanoscale Structures ◽  
Displacement Reactions ◽  
Materials Research ◽  
External Stimuli

DNA nanotechnology provides an excellent foundation for diverse nanoscale structures that can be used in various bioapplications and materials research. Among all existing DNA assembly techniques, DNA origami proves to be the most robust one for creating custom nanoshapes. Since its invention in 2006, building from the bottom up using DNA advanced drastically, and therefore, more and more complex DNA-based systems became accessible. So far, the vast majority of the demonstrated DNA origami frameworks are static by nature; however, there also exist dynamic DNA origami devices that are increasingly coming into view. In this review, we discuss DNA origami nanostructures that exhibit controlled translational or rotational movement when triggered by predefined DNA sequences, various molecular interactions, and/or external stimuli such as light, pH, temperature, and electromagnetic fields. The rapid evolution of such dynamic DNA origami tools will undoubtedly have a significant impact on molecular-scale precision measurements, targeted drug delivery and diagnostics; however, they can also play a role in the development of optical/plasmonic sensors, nanophotonic devices, and nanorobotics for numerous different tasks.

Recent Progress in Stimuli Responsive Intelligent Nano Scale Drug Delivery Systems: A special focus towards pH sensitive systems

2021 ◽  
Vol 22 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Ruckmani Kandasamy
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Special Focus ◽  
Stimuli Responsive ◽  
Ph Variation ◽  
Responsive Systems

Abstract: Stimuli responsive nanocarriers are gaining much attention due to its versatile multifunctional activities including disease diagnosis and treatment. Recently, clinical applications of nano drug delivery systems for cancer treatment make a considerable challenge due to its limited cellular uptake, low bioavailability, poor targetability, stability issues, and unfavourable pharmacokinetics. To overcome these issues researchers are focussing on stimuli responsive systems. Nano carriers elicit its role through endogenous (pH, temperature, enzyme and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimulus. These systems were designed to overcome the shortcomings such as non-specificity and toxicity associated with the conventional drug delivery systems. The pH variation between healthy cells and tumor microenvironment creates a platform towards the generation of pH sensitive nano delivery systems. Herein, we propose to present an overview of various internal and external stimuli responsive behavior based drug delivery systems. Herein the present review will focus specifically on the significance of various pH- responsive nanomaterials such as polymeric nanoparticles, nano micelles, inorganic based pH sensitive drug delivery carriers such as calcium phosphate nanoparticles, and carbon dots in cancer treatment. Moreover, this review elaborates the recent findings on pH based stimuli responsive drug delivery system with special emphasis towards our reported stimuli responsive systems for cancer treatment.

Recent advances of stimuli-responsive systems based on transition metal dichalcogenides for smart cancer therapy

2019 ◽  
Vol 7 (16) ◽  
pp. 2588-2607 ◽  
Author(s):  
Ruxin Zhou ◽  
Shuang Zhu ◽  
Linji Gong ◽  
Yanyan Fu ◽  
Zhanjun Gu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Transition Metal ◽  
Therapeutic Strategy ◽  
Transition Metal Dichalcogenides ◽  
Stimuli Responsive ◽  
Comprehensive Overview ◽  
Responsive Systems ◽  
Recent Advances ◽  
Metal Dichalcogenides

A comprehensive overview of the development of stimuli-responsive TMDC-based nanoplatforms for “smart” cancer therapy is presented to demonstrate a more intelligent and better controllable therapeutic strategy.

scholarly journals Nanopesticides in Agriculture: Benefits and Challenge in Agricultural Productivity, Toxicological Risks to Human Health and Environment

Toxics ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 131
Author(s):  
Marco Chaud ◽  
Eliana B. Souto ◽  
Aleksandra Zielinska ◽  
Patricia Severino ◽  
Fernando Batain ◽  
...  
Keyword(s):  
Environmental And Health Effects ◽  
Pesticide Exposure ◽  
Agricultural Productivity ◽  
Genetic Material ◽  
Engineered Nanoparticles ◽  
Three Dimensions ◽  
Stimuli Responsive ◽  
Responsive Systems ◽  
Fast Development ◽  
New Type

Nanopesticides are nanostructures with two to three dimensions between 1 to 200 nm, used to carry agrochemical ingredients (AcI). Because of their unique properties, the loading of AcI into nanoparticles offers benefits when compared to free pesticides. However, with the fast development of new engineered nanoparticles for pests’ control, a new type of environmental waste is being produced. This paper describes the nanopesticides sources, the harmful environmental and health effects arising from pesticide exposure. The potential ameliorative impact of nanoparticles on agricultural productivity and ecosystem challenges are extensively discussed. Strategies for controlled release and stimuli-responsive systems for slow, sustained, and targeted AcI and genetic material delivery are reported. Special attention to different nanoparticles source, the environmental behavior of nanopesticides in the crop setting, and the most recent advancements and nanopesticides representative research from experimental results are revised. This review also addresses some issues and concerns in developing, formulating and toxicity pesticide products for environmentally friendly and sustainable agriculture.

scholarly journals Design Principles for Aqueous Interactive Materials: Lessons from Small Molecules and Stimuli‐Responsive Systems

2020 ◽  
Vol 32 (20) ◽  
pp. 1906890 ◽  
Author(s):  
Jade A. McCune ◽  
Stefan Mommer ◽  
Christopher C. Parkins ◽  
Oren A. Scherman
Keyword(s):  
Small Molecules ◽  
Design Principles ◽  
Stimuli Responsive ◽  
Responsive Systems

Quantum Interference and Spin Filtering Effects in Photo-responsive Single Molecular Device

2021 ◽  
Author(s):  
Ashima Bajaj ◽  
Rishu Khurana ◽  
Md. Ehesan Ali
Keyword(s):  
Quantum Interference ◽  
Spin States ◽  
Molecular Device ◽  
Stimuli Responsive ◽  
Responsive Systems ◽  
External Stimuli ◽  
Spin Filtering

The development of stimuli responsive systems that can switch between two distinct spin states under the application of an external stimuli has always remained an illusory challenge. Here, we report...

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