scholarly journals Design Principles for Aqueous Interactive Materials: Lessons from Small Molecules and Stimuli‐Responsive Systems

2020 ◽  
Vol 32 (20) ◽  
pp. 1906890 ◽  
Author(s):  
Jade A. McCune ◽  
Stefan Mommer ◽  
Christopher C. Parkins ◽  
Oren A. Scherman
Keyword(s):  
Small Molecules ◽  
Design Principles ◽  
Stimuli Responsive ◽  
Responsive Systems

scholarly journals Aqueous interfacial gels assembled from small molecule supramolecular polymers

2017 ◽  
Vol 8 (2) ◽  
pp. 1350-1355 ◽  
Author(s):  
Alexander S. Groombridge ◽  
Aniello Palma ◽  
Richard M. Parker ◽  
Chris Abell ◽  
Oren A. Scherman
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Self Assembly ◽  
Hyperbranched Polymer ◽  
Soft Matter ◽  
Supramolecular Polymers ◽  
Supramolecular Network ◽  
Self Healing ◽  
Liquid Interfaces ◽  
Stimuli Responsive

The successful self-assembly of a stimuli-responsive aqueous supramolecular hyperbranched polymer from small molecules and the macrocyclic host cucurbit[8]uril (CB[8]) is reported. This self-healing supramolecular network can act as a soft matter barrier at liquid–liquid interfaces.

Recent Progress in Stimuli Responsive Intelligent Nano Scale Drug Delivery Systems: A special focus towards pH sensitive systems

2021 ◽  
Vol 22 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Ruckmani Kandasamy
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Special Focus ◽  
Stimuli Responsive ◽  
Ph Variation ◽  
Responsive Systems

Abstract: Stimuli responsive nanocarriers are gaining much attention due to its versatile multifunctional activities including disease diagnosis and treatment. Recently, clinical applications of nano drug delivery systems for cancer treatment make a considerable challenge due to its limited cellular uptake, low bioavailability, poor targetability, stability issues, and unfavourable pharmacokinetics. To overcome these issues researchers are focussing on stimuli responsive systems. Nano carriers elicit its role through endogenous (pH, temperature, enzyme and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimulus. These systems were designed to overcome the shortcomings such as non-specificity and toxicity associated with the conventional drug delivery systems. The pH variation between healthy cells and tumor microenvironment creates a platform towards the generation of pH sensitive nano delivery systems. Herein, we propose to present an overview of various internal and external stimuli responsive behavior based drug delivery systems. Herein the present review will focus specifically on the significance of various pH- responsive nanomaterials such as polymeric nanoparticles, nano micelles, inorganic based pH sensitive drug delivery carriers such as calcium phosphate nanoparticles, and carbon dots in cancer treatment. Moreover, this review elaborates the recent findings on pH based stimuli responsive drug delivery system with special emphasis towards our reported stimuli responsive systems for cancer treatment.

Synthesis and depolymerization of self-immolative poly(disulfide)s with saturated aliphatic backbones

2021 ◽  
Author(s):  
Magnus Hansen-Felby ◽  
Andreas Sommerfeldt ◽  
Martin Lahn Henriksen ◽  
Steen Uttrup Pedersen ◽  
Kim Daasbjerg
Keyword(s):  
Small Molecules ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
End Caps

Self-immolative polymers (SIPs) are a class of degradable stimuli-responsive polymers, which, upon removal of labile end-caps, depolymerize selectively and stepwise to small molecules.

Recent advances of stimuli-responsive systems based on transition metal dichalcogenides for smart cancer therapy

2019 ◽  
Vol 7 (16) ◽  
pp. 2588-2607 ◽  
Author(s):  
Ruxin Zhou ◽  
Shuang Zhu ◽  
Linji Gong ◽  
Yanyan Fu ◽  
Zhanjun Gu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Transition Metal ◽  
Therapeutic Strategy ◽  
Transition Metal Dichalcogenides ◽  
Stimuli Responsive ◽  
Comprehensive Overview ◽  
Responsive Systems ◽  
Recent Advances ◽  
Metal Dichalcogenides

A comprehensive overview of the development of stimuli-responsive TMDC-based nanoplatforms for “smart” cancer therapy is presented to demonstrate a more intelligent and better controllable therapeutic strategy.

Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery

2020 ◽  
Vol 8 (32) ◽  
pp. 7275-7287
Author(s):  
Parinaz Sabourian ◽  
Jeff Ji ◽  
Victor Lotocki ◽  
Alexandre Moquin ◽  
Ramez Hanna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hyaluronic Acid ◽  
Small Molecules ◽  
Protein Delivery ◽  
Stimuli Responsive ◽  
Glioblastoma Cells ◽  
One Pot ◽  
Self Assembled

Chitosan is functionalized with oxidative stress-sensitive thioketal entities in a one-pot methodology, and self-assembled into drugs or protein loaded dual stimuli responsive nanoparticles, which kill glioblastoma cells and increase nerve outgrowth.

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