scholarly journals Drug Delivery: Graphene-Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)

2018 ◽  
Vol 5 (2) ◽  
pp. 1870009 ◽  
Author(s):  
Ce Dou ◽  
Ning Ding ◽  
Fei Luo ◽  
Tianyong Hou ◽  
Zhen Cao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Formation ◽  
Increase Bone Formation

scholarly journals Graphene-Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization

2017 ◽  
Vol 5 (2) ◽  
pp. 1700578 ◽  
Author(s):  
Ce Dou ◽  
Ning Ding ◽  
Fei Luo ◽  
Tianyong Hou ◽  
Zhen Cao ◽  
...  
Keyword(s):  
Bone Formation ◽  
Increase Bone Formation

scholarly journals Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation

2020 ◽  
Vol 117 (49) ◽  
pp. 31070-31077 ◽  
Author(s):  
Nasir K. Bashiruddin ◽  
Mikihito Hayashi ◽  
Masanobu Nagano ◽  
Yan Wu ◽  
Yukiko Matsunaga ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Cyclic Peptides ◽  
Treatment Options ◽  
Affinity Maturation ◽  
Great Promise ◽  
Anabolic Activity ◽  
Anabolic Treatment ◽  
Increase Bone Formation

Osteoporosis is caused by a disequilibrium between bone resorption and bone formation. Therapeutics for osteoporosis can be divided into antiresorptives that suppress bone resorption and anabolics which increase bone formation. Currently, the only anabolic treatment options are parathyroid hormone mimetics or an anti-sclerostin monoclonal antibody. With the current global increases in demographics at risk for osteoporosis, development of therapeutics that elicit anabolic activity through alternative mechanisms is imperative. Blockade of the PlexinB1 and Semaphorin4D interaction on osteoblasts has been shown to be a promising mechanism to increase bone formation. Here we report the discovery of cyclic peptides by a novel RaPID (Random nonstandard Peptides Integrated Discovery) system-based affinity maturation methodology that generated the peptide PB1m6A9 which binds with high affinity to both human and mouse PlexinB1. The chemically dimerized peptide, PB1d6A9, showed potent inhibition of PlexinB1 signaling in mouse primary osteoblast cultures, resulting in significant enhancement of bone formation even compared to non-Semaphorin4D–treated controls. This high anabolic activity was also observed in vivo when the lipidated PB1d6A9 (PB1d6A9-Pal) was intravenously administered once weekly to ovariectomized mice, leading to complete rescue of bone loss. The potent osteogenic properties of this peptide shows great promise as an addition to the current anabolic treatment options for bone diseases such as osteoporosis.

Cell-mediated BMP-2 release from a novel dual-drug delivery system promotes bone formation

2013 ◽  
Vol 25 (12) ◽  
pp. 1412-1421 ◽  
Author(s):  
Tie Liu ◽  
Gang Wu ◽  
Yuanna Zheng ◽  
Daniel Wismeijer ◽  
Vincent Everts ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dual Drug

Biomimetics and Marine Materials in Drug Delivery and Tissue Engineering: From Natural Role Models to Bone Regeneration

2013 ◽  
Vol 587 ◽  
pp. 229-232 ◽  
Author(s):  
Besim Ben-Nissan
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Bone Formation ◽  
Role Models ◽  
Bone Growth ◽  
Mineral Metabolism ◽  
Building Blocks ◽  
Matrix Vesicles ◽  
Main Cluster ◽  
Macro Scale

During the last two decades learning from nature has given us new directions for the use of natural organic and inorganic skeletons, drug delivery devices, new medical treatment methods initiating unique designs and devices ranging from nanoto macro scale. These materials and designs have been instrumental to introduce the simplest remedies to vital problems in regenerative medicine, providing frameworks and highly accessible sources of osteopromotive analogues, naofibres, micro and macrospheres and mineralising proteins. This is exemplified by the biological effectiveness of marine structures such as corals and shells and sponge skeletons to house self-sustaining musculoskeletal tissues and to the promotion of bone formation by extracts of spongin and nacre seashells. Molecules pivotal to the regulation and guidance of bone morphogenesis and particularly the events in mineral metabolism and deposition similarly exist in the earliest marine organisms because they represent the first molecular components established for calcification, morphogenesis and wound healing. It emerges that bone morphogenic protein (BMP) molecules-the main cluster of bone growth factors for human bone morphogenesis-are secreted by endodermal cells into the developing skeleton. Signalling proteins, TGF and Wnt-prime targets in bone therapeutics-are present in early marine sponge development. Furthermore, ready-made organic and inorganic marine skeletons possess a habitat suitable for proliferating added mesenchymal stem cell populations and promoting clinically acceptable bone formation. In this paper we review the nature, morphology and extent of this association and use of these structures for bone grafts, drug delivery and extracts such as proteins for regenerative medicine. As an example, in human biology a study of matrix vesicles will teach us valuable lessons on how proteins are captured and coated; and how the vesicle is able to dock and fuse with their target. We will describe significant technological trends aimed at producing delivery vehicles using natural-origin soft and hard organized matter; fabricated into capsules and cell-delineated assemblies.Therole model for this specific biomimicry is the filtering microskeleton ofForaminifera. We will outline new selected strategies based on our and others works for the engineering of new bone, based on biomimicry themes using these bioceramics building blocks.

Do estrogens increase bone formation?

Bone ◽  
1991 ◽  
Vol 12 (5) ◽  
pp. 305-306 ◽  
Author(s):  
Charles H. Turner
Keyword(s):  
Bone Formation ◽  
Increase Bone Formation

Simvastatin-Loaded β-TCP Drug Delivery System Induces Bone Formation and Prevents Rhabdomyolysis in OVX Mice

2012 ◽  
Vol 2 (5) ◽  
pp. 678-681 ◽  
Author(s):  
Joshua Chou ◽  
Tomoko Ito ◽  
Makoto Otsuka ◽  
Besim Ben-Nissan ◽  
Bruce Milthorpe
Keyword(s):  
Drug Delivery ◽  
Bone Formation ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation

2016 ◽  
Vol 342 (2) ◽  
pp. 166-174 ◽  
Author(s):  
Isabel R. Orriss ◽  
Timothy R. Arnett ◽  
Jacob George ◽  
Miles D. Witham
Keyword(s):  
Bone Formation ◽  
Osteoblast Differentiation ◽  
Increase Bone Formation

scholarly journals Mesenchymal stem cells overexpressing BMP9 through CRISPR-Cas9 activation increase bone formation in rat calvarial defects

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100374
Author(s):  
Gileade Freitas ◽  
Helena Lopes ◽  
Alann Souza ◽  
Isabella Santos ◽  
Adriana Almeida ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Calvarial Defects ◽  
Increase Bone Formation
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