scholarly journals Graphene-Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization

2017 ◽  
Vol 5 (2) ◽  
pp. 1700578 ◽  
Author(s):  
Ce Dou ◽  
Ning Ding ◽  
Fei Luo ◽  
Tianyong Hou ◽  
Zhen Cao ◽  
...  
Keyword(s):  
Bone Formation ◽  
Increase Bone Formation

scholarly journals Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation

2020 ◽  
Vol 117 (49) ◽  
pp. 31070-31077 ◽  
Author(s):  
Nasir K. Bashiruddin ◽  
Mikihito Hayashi ◽  
Masanobu Nagano ◽  
Yan Wu ◽  
Yukiko Matsunaga ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Cyclic Peptides ◽  
Treatment Options ◽  
Affinity Maturation ◽  
Great Promise ◽  
Anabolic Activity ◽  
Anabolic Treatment ◽  
Increase Bone Formation

Osteoporosis is caused by a disequilibrium between bone resorption and bone formation. Therapeutics for osteoporosis can be divided into antiresorptives that suppress bone resorption and anabolics which increase bone formation. Currently, the only anabolic treatment options are parathyroid hormone mimetics or an anti-sclerostin monoclonal antibody. With the current global increases in demographics at risk for osteoporosis, development of therapeutics that elicit anabolic activity through alternative mechanisms is imperative. Blockade of the PlexinB1 and Semaphorin4D interaction on osteoblasts has been shown to be a promising mechanism to increase bone formation. Here we report the discovery of cyclic peptides by a novel RaPID (Random nonstandard Peptides Integrated Discovery) system-based affinity maturation methodology that generated the peptide PB1m6A9 which binds with high affinity to both human and mouse PlexinB1. The chemically dimerized peptide, PB1d6A9, showed potent inhibition of PlexinB1 signaling in mouse primary osteoblast cultures, resulting in significant enhancement of bone formation even compared to non-Semaphorin4D–treated controls. This high anabolic activity was also observed in vivo when the lipidated PB1d6A9 (PB1d6A9-Pal) was intravenously administered once weekly to ovariectomized mice, leading to complete rescue of bone loss. The potent osteogenic properties of this peptide shows great promise as an addition to the current anabolic treatment options for bone diseases such as osteoporosis.

Do estrogens increase bone formation?

Bone ◽  
1991 ◽  
Vol 12 (5) ◽  
pp. 305-306 ◽  
Author(s):  
Charles H. Turner
Keyword(s):  
Bone Formation ◽  
Increase Bone Formation

scholarly journals Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation

2016 ◽  
Vol 342 (2) ◽  
pp. 166-174 ◽  
Author(s):  
Isabel R. Orriss ◽  
Timothy R. Arnett ◽  
Jacob George ◽  
Miles D. Witham
Keyword(s):  
Bone Formation ◽  
Osteoblast Differentiation ◽  
Increase Bone Formation

scholarly journals Mesenchymal stem cells overexpressing BMP9 through CRISPR-Cas9 activation increase bone formation in rat calvarial defects

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100374
Author(s):  
Gileade Freitas ◽  
Helena Lopes ◽  
Alann Souza ◽  
Isabella Santos ◽  
Adriana Almeida ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Calvarial Defects ◽  
Increase Bone Formation

Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model

2009 ◽  
Vol 11 (5) ◽  
pp. 614-625 ◽  
Author(s):  
Nancy E. Lane ◽  
Donald B. Kimmel ◽  
Magnus H.L. Nilsson ◽  
Fred E. Cohen ◽  
Suellen Newton ◽  
...  
Keyword(s):  
Bone Formation ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Increase Bone Formation

The Anti-Bone-Resorptive Agent Calcitonin Also Actsin Vitroto Directly Increase Bone Formation and Bone Cell Proliferation*

Endocrinology ◽  
1988 ◽  
Vol 123 (1) ◽  
pp. 159-167 ◽  
Author(s):  
J. R. FARLEY ◽  
N. M. TARBAUX ◽  
S. L. HALL ◽  
T. A. LINKHART ◽  
D. J. BAYLINK
Keyword(s):  
Cell Proliferation ◽  
Bone Formation ◽  
Bone Cell ◽  
Bone Cell Proliferation ◽  
Increase Bone Formation

scholarly journals Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering

2015 ◽  
Vol 6 ◽  
pp. 204173141560944 ◽  
Author(s):  
Tegan L Cheng ◽  
Ciara M Murphy ◽  
Roya Ravarian ◽  
Fariba Dehghani ◽  
David G Little ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Formation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Ceramic Nanoparticles ◽  
Increase Bone Formation
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