Application of Taguchi Method to Investigate the Drug Release Behavior of Poly(Acrylamide-co-Maleic Acid)/Montmorillonite Nanocomposite Hydrogels

2014 ◽  
Vol 33 (4) ◽  
pp. n/a-n/a ◽  
Author(s):  
Daniyal Dadkhah ◽  
Amir H. Navarchian ◽  
Latif Aref ◽  
Naser Tavakoli
Keyword(s):  
Drug Release ◽  
Taguchi Method ◽  
Maleic Acid ◽  
Release Behavior ◽  
Nanocomposite Hydrogels ◽  
Drug Release Behavior ◽  
Poly Acrylamide

Drug release behavior of chitosan–montmorillonite nanocomposite hydrogels following electrostimulation

2008 ◽  
Vol 4 (4) ◽  
pp. 1038-1045 ◽  
Author(s):  
Kun-Ho Liu ◽  
Ting-Yu Liu ◽  
San-Yuan Chen ◽  
Dean-Mo Liu
Keyword(s):  
Drug Release ◽  
Release Behavior ◽  
Nanocomposite Hydrogels ◽  
Drug Release Behavior

scholarly journals Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2591
Author(s):  
Thuan Thi Duong ◽  
Antti Isomäki ◽  
Urve Paaver ◽  
Ivo Laidmäe ◽  
Arvo Tõnisoo ◽  
...  
Keyword(s):  
Thin Film ◽  
Drug Release ◽  
Size Distribution ◽  
Water Soluble ◽  
Release Behavior ◽  
Uniform Size ◽  
Ethanol Injection ◽  
Drug Release Behavior ◽  
Poorly Water Soluble

Berberine (BBR) is a poorly water-soluble quaternary isoquinoline alkaloid of plant origin with potential uses in the drug therapy of hypercholesterolemia. To tackle the limitations associated with the oral therapeutic use of BBR (such as a first-pass metabolism and poor absorption), BBR-loaded liposomes were fabricated by ethanol-injection and thin-film hydration methods. The size and size distribution, polydispersity index (PDI), solid-state properties, entrapment efficiency (EE) and in vitro drug release of liposomes were investigated. The BBR-loaded liposomes prepared by ethanol-injection and thin-film hydration methods presented an average liposome size ranging from 50 nm to 244 nm and from 111 nm to 449 nm, respectively. The PDI values for the liposomes were less than 0.3, suggesting a narrow size distribution. The EE of liposomes ranged from 56% to 92%. Poorly water-soluble BBR was found to accumulate in the bi-layered phospholipid membrane of the liposomes prepared by the thin-film hydration method. The BBR-loaded liposomes generated by both nanofabrication methods presented extended drug release behavior in vitro. In conclusion, both ethanol-injection and thin-film hydration nanofabrication methods are feasible for generating BBR-loaded oral liposomes with a uniform size, high EE and modified drug release behavior in vitro.

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