One-Pot Assembly of Fused Heterocycles via Oxidative Palladium-Catalyzed Cyclization of Arylols and Iodoarenes

2016 ◽  
Vol 358 (3) ◽  
pp. 353-357 ◽  
Author(s):  
Fenglin Hong ◽  
Yingwen Chen ◽  
Beili Lu ◽  
Jiajia Cheng
Keyword(s):  
One Pot ◽  
Fused Heterocycles ◽  
Palladium Catalyzed

Palladium-Catalyzed Stereoselective Aza-Wacker–Heck Cyclization: One-Pot Stepwise Strategy toward Tetracyclic Fused Heterocycles

2020 ◽  
Vol 22 (23) ◽  
pp. 9337-9341
Author(s):  
Rong-Shiow Tang ◽  
Li-Yuan Chen ◽  
Chin-Hung Lai ◽  
Ta-Hsien Chuang
Keyword(s):  
One Pot ◽  
Heck Cyclization ◽  
Fused Heterocycles ◽  
Palladium Catalyzed

scholarly journals The role of allyl ammonium salts in palladium-catalyzed cascade reactions towards the synthesis of spiro-fused heterocycles

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Fei Ye ◽  
Yao Ge ◽  
Anke Spannenberg ◽  
Helfried Neumann ◽  
Matthias Beller
Keyword(s):  
Cascade Reactions ◽  
Synthetic Methods ◽  
Ammonium Salts ◽  
One Pot ◽  
Pd Catalysts ◽  
Complex Molecules ◽  
Fused Heterocycles ◽  
Palladium Catalyzed ◽  
Ideal Tool

Abstract There is a continuous need for designing new and improved synthetic methods aiming at minimizing reaction steps while increasing molecular complexity. In this respect, catalytic, one-pot cascade methodologies constitute an ideal tool for the construction of complex molecules with high chemo-, regio-, and stereoselectivity. Herein, we describe two general and efficient cascade procedures for the synthesis of spiro-fused heterocylces. This transformation combines selective nucleophilic substitution (SN2′), palladium-catalyzed Heck and C–H activation reactions in a cascade manner. The use of allylic ammonium salts and specific Pd catalysts are key to the success of the transformations. The synthetic utility of these methodologies is showcased by the preparation of 48 spiro-fused dihydrobenzofuranes and indolines including a variety of fluorinated derivatives.

Tunable synthesis of quinolinone-fused isoquinolines through sequential one-pot nucleophilic addition and palladium-catalyzed intramolecular C–H alkenylation

2019 ◽  
Vol 17 (2) ◽  
pp. 321-332 ◽  
Author(s):  
Xue Li ◽  
Yunyun Bian ◽  
Xin Chen ◽  
Hang Zhang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
One Pot ◽  
One Pot Synthesis ◽  
Fused Heterocycles ◽  
Biological Interest ◽  
Palladium Catalyzed

An efficient sequential one-pot synthesis of N-fused heterocycles based on 4-quinolinone and isoquinoline scaffolds of biological interest has been developed.

One-Pot Multiple Lithiation Processes of Fused Heterocycles

2014 ◽  
Vol 2014 (32) ◽  
pp. 7226-7231 ◽  
Author(s):  
Adeline Jasselin-Hinschberger ◽  
Corinne Comoy ◽  
Yves Fort
Keyword(s):  
One Pot ◽  
Fused Heterocycles
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