Total Synthesis of Capsaicin Analogues from Lignin-Derived Compounds by Combined Heterogeneous Metal, Organocatalytic and Enzymatic Cascades in One Pot

2014 ◽  
Vol 356 (9) ◽  
pp. 2113-2118 ◽  
Author(s):  
Mattias Anderson ◽  
Samson Afewerki ◽  
Per Berglund ◽  
Armando Córdova
Keyword(s):  
Total Synthesis ◽  
One Pot ◽  
Enzymatic Cascades ◽  
Capsaicin Analogues

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

First total synthesis of oteromycin utilizing one-pot four-step cascade reaction strategy

2013 ◽  
Vol 54 (6) ◽  
pp. 506-511 ◽  
Author(s):  
Hiromi Uchiro ◽  
Nobuhiro Shionozaki ◽  
Ryo Tanaka ◽  
Hiroyuki Kitano ◽  
Naoki Iwamura ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cascade Reaction ◽  
One Pot

ChemInform Abstract: A One-Pot Preparation of Aryl- and Heteroarylcycloalkenes: Application to the Total Synthesis of (.+-.)-Laurokamurene B.

ChemInform ◽  
2010 ◽  
Vol 41 (9) ◽  
Author(s):  
Jean Tallineau ◽  
Georges Bashiardes ◽  
Jean-Marie Coustard ◽  
Frederic Lecornue
Keyword(s):  
Total Synthesis ◽  
One Pot

A One-Pot Preparation of Aryl- and Heteroarylcycloalkenes: Application to the Total Synthesis of (±)-Laurokamurene B

Synlett ◽  
2009 ◽  
Vol 2009 (17) ◽  
pp. 2761-2764 ◽  
Author(s):  
Frédéric Lecornué ◽  
Jean Tallineau ◽  
Georges Bashiardes ◽  
Jean-Marie Coustard
Keyword(s):  
Total Synthesis ◽  
One Pot

Total Synthesis of (−)-Hippodamine by Stereocontrolled Construction of Azaphenalene Skeleton Based on Extended One-Pot Asymmetric Azaelectrocyclization

2013 ◽  
Vol 15 (11) ◽  
pp. 2758-2761 ◽  
Author(s):  
Shintaro Fujita ◽  
Taku Sakaguchi ◽  
Toyoharu Kobayashi ◽  
Hiroshi Tsuchikawa ◽  
Shigeo Katsumura
Keyword(s):  
Total Synthesis ◽  
One Pot

ChemInform Abstract: Total Synthesis of (-)-Flustramine B via One-Pot Intramolecular Ullmann Coupling and Claisen Rearrangement.

ChemInform ◽  
2009 ◽  
Vol 40 (41) ◽  
Author(s):  
Tomohiro Hirano ◽  
Kanako Iwakiri ◽  
Hiroshi Miyamoto ◽  
Atsuo Nakazaki ◽  
Susumu Kobayashi
Keyword(s):  
Total Synthesis ◽  
Claisen Rearrangement ◽  
One Pot ◽  
Ullmann Coupling

A Convergent Total Synthesis of the Mucin Related F1αAntigen by One-Pot Sequential Stereoselective Glycosylation

2001 ◽  
Vol 30 (8) ◽  
pp. 840-841 ◽  
Author(s):  
Teruaki Mukaiyama ◽  
Kazuhiro Ikegai ◽  
Hideki Jona ◽  
Takashi Hashihayata ◽  
Kazuya Takeuchi
Keyword(s):  
Total Synthesis ◽  
One Pot ◽  
Stereoselective Glycosylation
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